Cerebrospinal fluid analysis Clinical neurochemistry
Autoimmune phenomena are of major importance in the pathogenesis of the main paraneoplastic diseases in humans. The autoimmune process is probably triggered by oncogenic antigens, which are cross-reactive or identical with certain neural antigens. Despite the known pathomechanism these syndromes are still considered as non-treatable. We report two cases of paraneoplastic cerebellar degeneration, in which intensive immunosuppression with cytostatics lead to considerable neurological improvement.
KeywordsHuman Immunodeficiency Virus Type Herpes Simplex Virus Type Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy Herpes Simplex Virus Encephalitis
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