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Studies on the Extracardial Effects of Nifedipine in Anesthetized Dogs

  • K. Hagemann
  • W. Lochner
  • B. Niehues

Abstract

In the mechanism of action of antianginal drugs like nifedipine, we have to distinguish between two components: effects on the heart itself—consisting of coronary and myocardial effects—on the one hand, and extracardial effects on the systemic and pulmonary circulation on the other. To a certain extent both components may improve the disproportion between oxygen supply and oxygen demand of the myocardium in coronary artery or primary myocardial disease [1, 2].

Keywords

Cardiac Output Arterial Pressure Peripheral Circulation Intravascular Volume Left Ventricular Pressure 
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References

  1. 1.
    Charlier, R.: Antianginal drugs. In: Handbuch der experimentellen Pharmakologie, Vol.XXXI. Berlin-Heidelberg-New York: Springer 1971.Google Scholar
  2. 2.
    Hagemann, K., Niehues, B., Schwanitz, V., Arnold, G., Lochner, W.: Untersuchungen zur extracardialen Komponente der Wirkung vasoaktiver Substanzen am Gesamtkreislauf des Hundes. Res. exp. Med. 161, 203 (1973).CrossRefGoogle Scholar
  3. 3.
    Mellander, S., Johansson, B.: Control of resistance, exchange and capacitance functions in the peripheral circulation. Pharmacolog. Rev. 20, 117 (1968).Google Scholar
  4. 4.
    Raff, W.K., Kosche, F., Lochner, W.: Untersuchungen mit Nifedipine, einer coronarge-fäßerweiternden Substanz mit schneller sublingualer Wirkung. Arzneim. Forsch. (Drug Res.) 22, 1376 (1972).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • K. Hagemann
    • 1
  • W. Lochner
    • 1
  • B. Niehues
    • 1
  1. 1.Physiologisches Institut IUniversität DüsseldorfFed. Rep. Germany

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