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Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat

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2nd International Adalat® Symposium

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Abstract

As long as there is no causal therapy of coronary disease, treatment of coronary insufficiency can only be symptomatic and prophylactic. Animal experiments by Vater et al. [4] demonstrated that nifedipine causes a rapid, long-lasting increase of coronary blood flow.

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References

  1. Hayase, S., Hirakawa, S., Hosokawa, S., Mori, N., Kanyama, S., Iwasa, M.: Hemodynamic and therapeutic effect of BAY a 1040 on the patients with ischemic heart disease. Arzneim.-Forsch. (Drug Res.) 22, 370–372 (1972).

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  2. Kimura, F., Mabuchi, G., Kikuchi, H.: The clinical effect of 4-(2′-nitrophenyl)-2, 6-di-methyl-3, 5-dicarbomethoxy-l, 4-dihydropyridine(BAY a 1040) on angina pectoris evaluated by sequential analysis. Arzneim.-Forsch. (Drug Res.) 22, 365–367 (1972).

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  3. Loos, A., Kaltenbach, M.: Die Wirkung von Nifedipine (BAY a 1040) auf das Belastungs-Elektrokardiogramm von Angina-pectoris-Kranken. Arzneim.-Forsch. (Drug Res.) 22, 358–365 (1972).

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  4. Vater, W., Kroneberg, G., Hoffmeister, F., Kaller, H., Meng, K., Oberdorf, A., Puls, W., Schlossmann, K., Stoepel, K.: Zur Pharmakologie von 4-(2′-Nitrophenyl)-2, 6-dimethyl-l, 4-dihydropyridin-3, 5-dicarbonsäuredimethylester (Nifedipine, BAY a 1040). Arzneim.-Forsch. (Drug Res.) 22, 1–14 (1972).

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Authors and Affiliations

  1. Abteilung für experimentelle Chirurgie, Universität Heidelberg, Fed. Rep. Germany

    J. Schmier, K. van Ackern, U. B. Brückner, B. Hakimi, W. Heger & J. Simo

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  1. J. Schmier
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  2. K. van Ackern
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  3. U. B. Brückner
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  4. B. Hakimi
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  5. W. Heger
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  6. J. Simo
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Editor information

Wilhelm Lochner (President)Wolfgang Braasch Günther Kroneberg

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© 1975 Springer-Verlag Berlin Heidelberg

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Schmier, J., van Ackern, K., Brückner, U.B., Hakimi, B., Heger, W., Simo, J. (1975). Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat. In: Lochner, W., Braasch, W., Kroneberg, G. (eds) 2nd International Adalat® Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39666-7_13

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  • DOI: https://doi.org/10.1007/978-3-662-39666-7_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38770-2

  • Online ISBN: 978-3-662-39666-7

  • eBook Packages: Springer Book Archive

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