Skip to main content
SpringerLink
Log in

Therapy with high-energy heavy particles

  • Chapter
Allgemeine Strahlentherapeutische Methodik Teil 2 / Methods and Procedures of Radiation Therapy Part 2

  • 23 Accesses

Abstract

In application of radiations to medical problems the desired circumstance naturally is to restrict the irradiation to the target volume. For irradiation of subsurface tissues by an external source this is, of course, not possible and the dose which may be delivered may often be limited by the dose which is judged acceptable to overlying tissues in the path of the projected beam. The minimization, therefore, of this necessary but undesirable radiation exposure has been a long sought goal, especially where circumstance require the irradiation of deep-seated tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aamodt, K. L., V. Peterson and E. Phillips: C12 (P, Pn) C11 cross-section from threshold to 340 MeV. Univ. of Calif. Kadiation Laboratory Keport No UCEL —1400, 1951.

    Google Scholar 

  • Ammiraju, P., and L. M. Lederman: Diffusion chamber study of very slow mesons. IV. Absorption of pions in light nuclei. Nuovo Cimento 4, 283–306 (1956).

    Article  CAS  Google Scholar 

  • Barkas, W. H., and M. J. Berger: Tables of energy losses and ranges of heavy charged particles. National Aeronautic and Space Administration Report No NASA SP-3013 and Chap. 10 in: Studies in penetration of charged particles in matter, National Academy of Sciences — National Research Council Publication No 1133.

    Google Scholar 

  • Birge, A.C., H. O. Anger and C. A. Tobias: Heavy charged particle beams. In Handbook of radiation dosimetry, Chap. 14. Hine and Brownell eds. New York: Academic Press 1955.

    Google Scholar 

  • Bond, V. P., M. N. Swift, S. T. Taketa, G. P. Welch and C. A. Tobias: Indirect effects of localized deuteron irradiation of the rat. Amer. J. Physiol. 174, 259–263 (1953).

    PubMed  CAS  Google Scholar 

  • Bonét-Maury, P., A. Deysine, M. Frilley et C. Stefan: Efficacité biologique relative des protons de 157 MeV. C. R. Acad. Sci (Paris) 251, 3087–3089 (1960).

    Google Scholar 

  • Born, J. L., O. K. Anderson, H. O. Anger, A. C. Birge, P. Blanquet, T. Brustad, R. A. Carlson, D. C. van Dyke, D. J. Fluke, J. Garcia, J. P. Henry, R. M. Kinsely, J. H. Lawrence, C. W. Riggs, B. Thorell, C. A. Tobias, P. Toch and G. P. Welch: Biological and medical studies with high-energy particle accelerators. Proc. of the Second United Nations Internat. Conference on the Peacefull Uses of Atomic Energy, Geneva 1958, vol. 26, p. 317-326.

    Google Scholar 

  • Brustad, T.: Heavy ions and some aspects of their use in molecular and cellular radiobiology. In: Advances in biological and medical physics (Tobias and Lawrence, eds.), vol. VIII, p. 161–224. New York: Academic Press 1962.

    Google Scholar 

  • Falkmer, S., B. Larsson and S. Sténson: Effects of single-dose proton irradiation of normal skin and Vx 2 carcinoma in rabbit ears. A comparative investigation with protons and roentgen rays. Acta radiol. (Stockh.) 52, 217–234 (1959).

    Article  CAS  Google Scholar 

  • Fors, B., B. Larsson, A. Lindell, J. Naeslund and S. Stenson: Effect of high-energh protons on human genital carcinoma. Acta radiol. (Stockh.) 2, 384–398 (1964).

    CAS  Google Scholar 

  • Fowler, P. H., and D. H. Perkins: Possibility of therapeutic applications of beams of negative-mesons. Nature (Lond.) 189, 524–528 (1961).

    Article  CAS  Google Scholar 

  • Giles, N. H., and C. A. Tobias: Effect of linear energy transfer on radiation induced chromosome aberrations in Tradescantia microspores. Science 120, 993 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Gordon, H. S., and G. A. Behman: Particle accelerators. Amer. Inst. Phys. Handbook, 2nd ed., sec. 81, p. 168–222. New York: McGraw-Hill 1963.

    Google Scholar 

  • Kennedy, B. J., W. T. Peyton and L. A. French: Total hypophysectomy in advanced breast cancer. Bull. Univ. Minnesota Hosp. 26, 528–551 (1955).

    Google Scholar 

  • Kennedy, T., T. Rasmussen and P. V. Harper: The use of a beta-ray source for destruction of the hypophysis. Surg. Forum 4, 681–686 (1953).

    PubMed  Google Scholar 

  • Kjellberg, R. N., R. A. Field, J. W. McMeel and W. H. Sweet: Bragg-peak pituitary destruction for diabetic retinopathy. Third International Congress Neurosurgery Copenhagen, 1965.

    Google Scholar 

  • Kjellberg, R. N., A. M. Koehler, W. M. Preston and W. H. Sweet: Stereotaxic instrument for use with the Bragg peak of a proton beam. First Int. Symp. Stereoencephalotomy. Confin. neurol. (Basel) 22, 183–189 (1962).

    Article  CAS  Google Scholar 

  • Kjellberg, R. N., A. M. Koehler: Intracranial lesions made by the Bragg peak of a proton beam. In: Response of the nervous system to ionizing radiations (Haley and Snider, ed.). Boston: Little Brown&Co. 1964.

    Google Scholar 

  • Koehler, A. M., J. D. Dickinson and W. M. Preston: The range of protons in human skullbone. Kadiat. Ees. 26, 334–342 (1965).

    CAS  Google Scholar 

  • Lacassagne, A., and W. Nyke: Procédé de destruction de l’hypophyse du lapin par le radon. C. E. Soc. Biol. (Paris) 117, 956–958 (1934).

    Google Scholar 

  • Larsson, B.: Pre-therapeutic physical experiments with high-energy protons. Brit. J. Eadiol. 34, 143–151 (1961).

    CAS  Google Scholar 

  • Larsson, B., and B. A. Kihlman: Chromosome aberrations following irradiation with high-energy protons and their secondary radiation. A study of dose distribution and biological efficiency using root-tips of Vicia faba and Allium cepa. Int. J. Eadiol. Biol. 2, 8–19 (1960).

    CAS  Google Scholar 

  • Larsson, B., L. Leksell and B. Eexed: The use of high-energy protons for cerebral surgery in man. Acta chir. scand. 125, 1–7 (1963).

    Google Scholar 

  • Larsson, B., P. Sourander, W. Mair and B. Andersson: The high-energy proton beam as a neurosurgical tool. Nature (Lond.) 182, 1222–1223 (1958).

    Article  CAS  Google Scholar 

  • Larsson, B., P. Sourander, W. Mair and B. Andersson: Effect of high-energy protons on the spinal cord. Acta radiol. (Stockh.) 51, 52–64 (1959).

    Article  CAS  Google Scholar 

  • Lawrence, E. O., and N. E. Edlefsen: On the production of high-speed protons. Science 72, 376–377 (1930).

    Google Scholar 

  • Lawrence, J. H.: Proton irradiation of the pituitary. Cancer (Philad.) 10, 795–798 (1957).

    Article  CAS  Google Scholar 

  • Lawrence, J. H., J. L. Born, C. A. Tobias, E. Carlson, F. Sangalli and G.P. Welch: Clinical and metabolic studies in patients after alphaparticle subtotal or total hypophysectomy. Paper presented at First Congr. of the Confederation of Medical Ass. in Asia and Oceania, 1959.

    Google Scholar 

  • Lawrence, J. H., and C. A. Tobias: Eadioactive isotopes and nuclear radiations in the treatment of cancer. Cancer Ees. 16, 185–193 (1956).

    CAS  Google Scholar 

  • Lawrence, J. H., J. L. Born, F. Sangalli, E. A. Carlson and J. A. Linfoot: Heavy-particle therapy in acromegaly. Acta radiol. (Stockh.) 58, 337 (1962).

    Article  Google Scholar 

  • Lawrence, J. H., C. C. Wang and J. H. Linfoot: Heavyparticle irradiation in neoplastic and neurologic disease. J. Neurosurg. 19, 717–722 (1962a).

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, J. H., C. C. Wang, J. A. Linfoot, J. L. Born, A. Gottschalk and E. P. Kling: Heavy particles, the Bragg curve and suppression of pituitary function in diabetic retinopathy. Diabetes 12, 490–501 (1963).

    PubMed  CAS  Google Scholar 

  • Lawrence, J. H., E. Manougian and J. Lyman: Heavy particles and the bragg peak in therapy. Ann. intern. Med. 62, 400–407 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Leksell, L., B. Larsson, B. Andersson, B. Eexed, P. Sourander and W. Mair: Lesions in the depth of the brain produced by a beam of high-energy protons. Acta radiol. (Stockh.) 54, 251–264 (1960).

    Article  CAS  Google Scholar 

  • Linfoot, J. A., J. H. Lawrence, J. L. Born and C. A. Tobias: Alpha-particle or proton beam in radiosurgery of the pituitary gland for Cushing’s disease. New Engl. J. Med. 269, 597 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Luft, E., and H. Olivecrona: Experiences with hypophysectomy in man. J. Neurosurg. 10, 301–316 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Luft, E., and H. Olivecrona: Hypophysectomy in man. Experience in metastatic cancer of the breast. Cancer (Philad.) 8, 261–270 (1955).

    Article  CAS  Google Scholar 

  • Luft, E., D. Ikkos, T. Kornerup and H. Ljunggren: Hypophysectomy in man: further experiences in severe diabetes mellitus. Brit. med. J. 2, 752–762 (1955b).

    Article  PubMed  CAS  Google Scholar 

  • Luft, E., D. Ikkos, and B. Sjogren: Hypophysectomy in man. iExperiences in severe diabetes. J. clin. Endocr. 15, 391–408 (1955a).

    Article  PubMed  CAS  Google Scholar 

  • Oldfield, D. G.: Private communication, June 1959.

    Google Scholar 

  • Pearson, O. H., B. S. Eay, C. C. Harrold, C. D. West, M. C. Li, J. P. McLean and M.B. Lipsett: Hypophysectomy in the treatment of advanced cancer. Trans. Ass. Amer.Phycns 68, 101–111 (1955).

    CAS  Google Scholar 

  • Eexed, B., W. Mair, P. Sourander, B. Larsson and L. Leksell: Effect of high-energy protons on the brain of the rabbit. Acta radiol. (Stockh.) 53, 289–299 (1960).

    Article  Google Scholar 

  • Eichman, C., H. Aceto, M. E. Eaju and B. Schwartz: The radiotherapeutic possibilities of negative pions. Amer. J. Eoentgenol. 96, 777–790 (1966).

    Article  Google Scholar 

  • Sallmann, L. v., C. A. Tobias, H. O. Anger, G. P. Welch, S. F. Kimura, C. M. Munoz and A. Drungis: Effects of high-energy particles, x-rays and aging on lens epithelium. A.M.A. Arch. Ophthal. 54, 489–514 (1955).

    Article  Google Scholar 

  • Simpson, M. E., G. van Wagenen, D. C. van Dyke, A. A. Koneff and C. A. Tobias: Deuteron irradiation of the monkey pituitary. Endocrinology 65, 831–857 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Tobias, C. A., H. O. Anger and J. H. Lawrence: Eadiological use of high-energy deuterons and alpha particles. Amer. J. Eoentgenol. 67, 1–27 (1952).

    CAS  Google Scholar 

  • Tobias, C. A., K. Hsu and J. L. Born: Biological and medical studies with accelerators. Eadiation Biology and Medicine, chapt 22, edit. W. D. Claus Eeading, Mass.: Addison-Wesley 1958.

    Google Scholar 

  • Tobias, C. A., J. H. Lawrence, J. L. Born, E. K. McCombs, J. E. Eoberts, H. O. Anger, B. V. A. LowBeer and C. B. Huggins: Pituitary irradiation with high-energy proton beams; a preliminary report. Cancer Ees. 18, 121–134 (1958).

    CAS  Google Scholar 

  • Tobias, C. A., J. Lyman, J. L. Born, A. Gottschalk, J. Linfoot and J. McDonald: Progress report on pituitary irradiation. In: Eesponse of tho nervous system to ionizing radiation (Haley and Snider, eds.). Boston: Little Brown 1964.

    Google Scholar 

  • Tobias, C. A., J. E. Eoberts, J. H. Lawrence, B.V.A Low-Beer, H. O. Anger, J. L. Born, E. Me Combs and C. Huggins: Eadiation hypophysectomy with high-energy proton beams. Univ. of Calif. Eadiation Laboratory Eeport No UCEL—3035, 1955.

    Google Scholar 

  • Tobias, C.A., J. E. Eoberts, J. H. Lawrence, B.V.A. Low-Beer, H.O. Anger, J.L. Born, K. McCombs and C. Huggins: Irradiation hypophysectomy and related studies using 340-Mev protons and 190-Mev deuteron. Proc. Internat. Conference on the Peaceful Uses of Atomic Energy, Geneva 1955, vol. 10, 95-106. New York: United Nations 1956.

    Google Scholar 

  • Tobias, C.A., D. C. van Dyke, M. E. Simpson, H. O. Anger, E. L. Huff and A. A. Koneff: Irradiation of the pituitary of the rat with high-energy deuterons. Amer. J. Koentgenol. 72, 1–21 (1954).

    CAS  Google Scholar 

  • van Dyke, D. C., M. E. Simpson, A. A. Koneff and C. A. Tobias: Long term effects of deuteron irradiation of the rat pituitary. Endocrinology 64, 240–257 (1959).

    Article  Google Scholar 

  • Warshaw, S. D., and D. G. Oldfield: Pretherapeutic studies with the Chicago synchrocyclotron. Amer. J. Eoentgenol. 78, 876–886 (1957).

    CAS  Google Scholar 

  • Williamson, C. F., J. P. Boujot and J. Picard: Tables of range and stopping power of chemical elements for charged particles of energy 0.05 to 500 MeV. Commissariat à l’Energie Atomique Eapport CEA-E 3042 (1966).

    Google Scholar 

  • Wilson, E. E.: Eadiological use of fast protons. Eadiology 47, 487–491 (1946).

    CAS  Google Scholar 

Download references

Authors
  1. G. P. Welch
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Düsseldorf, Deutschland

    H. Vieten

  2. München, Deutschland

    F. Wachsmann

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Welch, G.P. (1971). Therapy with high-energy heavy particles. In: Vieten, H., Wachsmann, F. (eds) Allgemeine Strahlentherapeutische Methodik Teil 2 / Methods and Procedures of Radiation Therapy Part 2. Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39629-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-39629-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38742-9

  • Online ISBN: 978-3-662-39629-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation