Prostaglandin-Induced cAMP Synthesis in Peripheral Nerve

  • Peter Kalix

Abstract

Prostaglandins of the E series induce an acceleration of cAMP synthesis in peripheral nerve tissue from several species. For example, exposure to PE 1 increases the cAMP content in calf vagus nerve twofold and in that of the rabbit threefold; PE 2 has a comparable effect. Similarly, PE 1 increases the cAMP synthesis in the superior cervical ganglion of calf, rat and rabbit; in these tissues, however, the presence of a phosphodiesterase inhibitor is required for accumulation of the nucleotide.

Keywords

Prostaglandin Ghost Phosphodiesterase Isoprenaline Adenyl 

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • Peter Kalix
    • 1
  1. 1.Département de Pharmacologie de l’UniversitéGenève 4Schweiz

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