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Investigations on DPH Protein Binding

  • A. Haass
  • K. W. Pflughaupt
  • A. Schütz

Abstract

Generally in clinical practice only the total plasma concentration of anti-epileptic drugs and not the unbound fraction is measured. For highly protein bound drugs as DPH(Diphenylhydantoin) this would be sufficient if the proportion of the unbound fraction is nearly the same in all patients. But large and small variations in the extent of DPH plasma protein binding have been reported.

Keywords

Antiepileptic Drug Albumin Concentration Unbind Fraction Sodium Valproate Total Plasma Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • A. Haass
    • 1
  • K. W. Pflughaupt
    • 1
  • A. Schütz
    • 1
  1. 1.Depart. of Neurology87 WürzburgGermany

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