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Antagonism by Opiates Against Prostaglandin E2-Stimulated Adenylate Cyclase in the Corpus Striatum

  • K. Kuschinsky
  • U. Havemann

Abstract

The actions of opiates on the elevation of cyclic AMP (cAMP), induced by prostaglandin E2 (PGE2), were studied in slices of the rat striatum. Morphine (2μM) antagonized the PGE2-induced elevation of cAMP, while an equimolar concentration of naloxone inhibited morphine’s effect. The action of morphine was mimicked by met-enkephalin (100μM, in presence of 0.2 mM bacitracin) and by levorphanol (10μM), but not by an equimolar concentration of its stereoisomer dextrorphan. Adenosine (1mM) or an elevation of K+ -ions to 54 mM raised the cAMP concentration, and PGE2 induced a further elevation, which however, was not antagonized by morphine under these conditions.

Keywords

Shock Intensity Equimolar Concentration Corpus Striatum Abstinence Syndrome Escape Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • K. Kuschinsky
    • 1
  • U. Havemann
    • 1
  1. 1.Abt. Biochemische PharmakologieMax-Planck-Institut für Experimentelle MedizinGöttingenGermany

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