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Substance P in Circulating Blood: Origin and Elimination

  • F. Lembeck
  • R. Gamse
  • M. Schweditsch
  • P. Holzer

Abstract

Substance P (SP) in plasma of fasted cats was found to be 69.3±9.8 fmol/ml (SEM, n = 25, radioimmunassay of extracted plasma). Evisceration lowered the concentration to 28.7±9.0% (n = 5, p < 0.01) after 15 min and to 24.7±9.9% (n = 4, p < 0.01) after 60 min. Ligation of all intestinal arteries and the portal vein reduced the concentration to 55.4±14.1% (n = 7, p < 0.05). No difference between the concentration of SP in portal plasma and in plasma of the V. cava inferior was found (71.8±11.2 versus 68.3±12.1 fmol/ml, n = 6). These results suggest, that the origin of circulating SP is mainly the intestine.

Keywords

Synaptic Vesicle Repeated Treatment Maximal Serum Maximal Serum Concentration Compartment Open Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • F. Lembeck
    • 1
  • R. Gamse
    • 1
  • M. Schweditsch
    • 1
  • P. Holzer
    • 1
  1. 1.Institut für Experimentelle und Klinische PharmakologieGrazAustria

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