The Effect of Anticholinergics on Four Parameters Recorded Simultaneously in Rats
Pharmacological investigations on differentiated effects of anticholinergic drugs on the gastric or salivary secretion are generally carried out on various species (rat, mouse). In order to exclude any possible differences present in the species in these experiments, an experimental procedure was set up in which the influence on organ functions stimulated peripherially and cholinergically by anti-cholinergics can be investigated in one experimental animal (anaesthetized rat). In this case the gastric secretion is determined according to the method of Lai (Gut 5: 327,1964). At the same time the mouth cavity is perfused with physiological NaCl and the salivary secretion is recorded gravimetrically as the difference between the quantity entering into and flowing out of the mouth cavity. In addition the small intestinal motility is recorded with a balloon catheter as well as the heart rate with the ECG.