Experimental Osteoarthrosis for Pharmacological Anti-Arthrotic Compounds
Using adult hens as laboratory animals we found that 2 intraarticular injections of 0,25 mg or 0,5 mg iodo-acetate into the knee joint can induce experimental osteoarthrosis within a period of 2–3 months. By macroscopical, histological and biochemical criteria the slowly progressing degenerations in the joint are in good correlation with human osteoarthrosis. In pharmacological experiments we tried to inhibit the degenerative processes in our model of osteoarthrosis by treatment with natural and semisynthetic acidic polysaccharides: pentosan polysulfate (SP-54), DAK-16 (from RumalonR) and a mucopolysaccharide polysulfate (ArteparonR). After weekly intraarticular applications of these compounds in a dose range of 0,001 mg – 0,1 mg per injection a significant anti-arthrotic potency could be demonstrated, while higher doses had no or an adverse effect.