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Pharmacodynamic and Pharmacokinetic Actions of Midodrine and ST 1059

  • H. Pittner

Abstract

The alpha-adrenergic stimulating agent midodrine (1-(2′,5′-dimethoxyphenyl) — 2 — glycineamido — ethanol(1)) is well absorbed from the gastro — intestinal tract after oral administration. Midodrine has been suggested to be the “transport form” from which the pharmacologically active main metabolite ST 1059 (1-(2′,5′-dimethoxy — phenyl)-2-amino-ethanol(1))is formed by the enzymatic cleavage of glycine.

Keywords

Calf Muscle Minute Volume Splanchnic Nerve Transport Form Intrinsic Sympathomimetic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • H. Pittner
    • 1
  1. 1.CHEMIE LINZ AG, PharmakologieLinzAustria

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