Differences in Susceptibility to Peptides between Heart and Vas Deferens of the Guinea Pig

  • H. Iven
  • E. Kampmann
  • R. Pursche
  • G. Zetler

Abstract

The following peptides were inactive in the non-stimulated isolated vas deferens but increased the twitch due to field stimulation in a dose-dependent manner (mean pD2 values): an-giotensin II amide (A II: 8.1), substance P (SP: 7.8), bradykinin (B: 7.1). The same effects of acetylcholine (6.4) and carbachol (6.5) were antagonized by atropine (pA2 8.0), but the peptide effects were resistant. The specific A II antagonist sar1-ala8-A II left the twitch response unchanged and antagonized competitively (pA2 7.52) the twitch-enhancing effect of A II but not that of SP and B.

Keywords

Magnesium Amide Hydrochloride Noradrenaline Adrenaline 

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • H. Iven
    • 1
  • E. Kampmann
    • 1
  • R. Pursche
    • 1
  • G. Zetler
    • 1
  1. 1.Abteilung für PharmakologieMedizinische HochschuleLübeckGermany

Personalised recommendations