Abstract
The following peptides were inactive in the non-stimulated isolated vas deferens but increased the twitch due to field stimulation in a dose-dependent manner (mean pD2 values): an-giotensin II amide (A II: 8.1), substance P (SP: 7.8), bradykinin (B: 7.1). The same effects of acetylcholine (6.4) and carbachol (6.5) were antagonized by atropine (pA2 8.0), but the peptide effects were resistant. The specific A II antagonist sar1-ala8-A II left the twitch response unchanged and antagonized competitively (pA2 7.52) the twitch-enhancing effect of A II but not that of SP and B.
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© 1978 Springer-Verlag Berlin Heidelberg
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Iven, H., Kampmann, E., Pursche, R., Zetler, G. (1978). Differences in Susceptibility to Peptides between Heart and Vas Deferens of the Guinea Pig. In: Deutsche Pharmakologische Gesellschaft. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39532-5_128
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DOI: https://doi.org/10.1007/978-3-662-39532-5_128
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38666-8
Online ISBN: 978-3-662-39532-5
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