Advertisement

Differences in Susceptibility to Peptides between Heart and Vas Deferens of the Guinea Pig

  • H. Iven
  • E. Kampmann
  • R. Pursche
  • G. Zetler

Abstract

The following peptides were inactive in the non-stimulated isolated vas deferens but increased the twitch due to field stimulation in a dose-dependent manner (mean pD2 values): an-giotensin II amide (A II: 8.1), substance P (SP: 7.8), bradykinin (B: 7.1). The same effects of acetylcholine (6.4) and carbachol (6.5) were antagonized by atropine (pA2 8.0), but the peptide effects were resistant. The specific A II antagonist sar1-ala8-A II left the twitch response unchanged and antagonized competitively (pA2 7.52) the twitch-enhancing effect of A II but not that of SP and B.

Keywords

Positive Inotropic Effect Field Stimulation Left Auricle Positive Inotropic Response High Adrenaline Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • H. Iven
    • 1
  • E. Kampmann
    • 1
  • R. Pursche
    • 1
  • G. Zetler
    • 1
  1. 1.Abteilung für PharmakologieMedizinische HochschuleLübeckGermany

Personalised recommendations