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Intestinal Absorption of Cobalt and Iron: Interaction and Subcellular Distribution

  • G. Becker

Abstract

The absorption kinetic 10 min after administration of 59Fe-(FeCl3) and 60Co-(CoCl2) in increasing doses (0,5 – 1000 ng-at metal) in tied off duodenal segments of normal and iron-deficient (d) rats shows saturation characteristic for both metals. The effect of cobalt on iron absorption was studied in d rats at iron doses of 10 and 200 ng-at iron. When administring 200 ng-at iron the presence of 108 ng-at cobalt caused a reduction of iron absorption to 40 percent; excess of cobalt (1080 ng-at) diminished iron absorption to about 9 percent, whereas the uptake of iron into the mucosa did not differ from the controls. In an equal amount, however, cobalt (9 ng-at) did not diminish the absorption of iron (10 ng-at 59Fe-(FeCl3).

Keywords

Bile Salt Cholera Toxin Subcellular Distribution Adenylate Cyclase Activity Fluid Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • G. Becker
    • 1
    • 2
  1. 1.Institut für Pharmakologie und ToxikologieRUBBochumGermany
  2. 2.Institut für Pharmakologie und ToxikologieUniversität des SaarlandesHomburg/SaarGermany

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