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Planning and Execution of Multistep Syntheses

  • Chapter
Part B: Reactions and Synthesis

Part of the book series: Advanced Organic Chemistry ((AOC,volume Pt. B))

Abstract

The reactions that have been discussed in the preceding chapters provide the tools for synthesizing new and complex molecules. However, a strategy for using these tools is essential to successful synthesis of molecules by multistep synthetic sequences. The sequence of individual reactions must be planned so that they are mutually compatible. Certain functional groups can interfere with prospective reactions, and such problems must be avoided either by a modification of the sequence or by temporarily masking (protecting) the interfering group. Protective groups are used to temporarily modify functionality, which is then restored when the protecting group is removed. Another approach is to use synthetic equivalent groups in which a particular functionality is introduced as an alternative structure that can subsequently be converted to the desired group.

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    Francis A. Carey & Richard J. Sundberg

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Carey, F.A., Sundberg, R.J. (2001). Planning and Execution of Multistep Syntheses. In: Part B: Reactions and Synthesis. Advanced Organic Chemistry, vol Pt. B. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39510-3_13

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