The extensive use of the techniques of tissue culture during the past 15 years has permitted the isolation of many new viral agents both from man and lower animals. These viruses have been isolated either by the inoculation of body fluids, excreta, or tissue homogenates, into previously prepared cultures, or by direct isolation of viruses from cultures prepared from apparently healthy animal tissues. This latter technique has been referred to as “unmasking of viruses”. It was first demonstrated by the recovery of adenoviruses from cultures of “normal” human adenoid tissue (111), but we now know that a number of viruses can remain latent in tissues, and are undetectable by ordinary methods of virus isolation. When cells from such tissues are cultured in vitro, these latent viruses are freed, or released, from whatever bond (specific antibody, interferon) has held them in a state of equilibrium with their host. The virus so “freed” may produce a cytopathic effect (CPE), which indicates its presence, but, in some instances, such as in the case of rubella or SV5 viruses, it may be necessary to use other technics to detect the presence of the virus. By these methods, virologists have recovered many new agents from both healthy and sick individuals, but in the latter case, it frequently was difficult to determine whether or not the virus isolated was the cause of the illness.


Cynomolgus Monkey Measle Virus Simian Virus Monkey Kidney African Green Monkey 
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Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Robert N. Hull
    • 1
  1. 1.Lilly Research LaboratoriesIndianapolisUSA

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