Abstract
Phleomycin was isolated from a culture of Streptomyces verticillius by Maeda et al. (1956). It is a water-soluble copper containing antibiotic complex and is effective against a variety of bacteria. The antibiotic can be freed of its copper by treatment with 8-hydroxy-quinoline and can regain its copper on addition of CuSO4. The copper-free phleomycin had almost the same antibacterial activity as the copper containing antibiotic except against mycobacteria, where the former was less active (Takita, 1959). Some of the chemical and biological properties of phleomycin are listed in Table 1.
Keywords
- Minimum Inhibitory Concen
- Phenazine Methosulfate
- Antibiotic Complex
- Marginal Inhibition
- Improve Tissue Culture
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References
Bhuyan, B. K., and A. D. Dietz: Nogalamycin: Fermentation, taxonomic and biological studies, Antimicrobial Agents and Chemotherapy, p. 836 (1965).
Bhuyan, B. K., and C. G. Smith: Differential interaction of nogalamycin with Dna of varying base composition. Proc. Natl Acad. Sci. U.S. 54, 566 (1965a).
Bitteva, M. B.: The taxonomic position of the actinomycete producing aurantin. Mikrobiologiya (Transi.) 31, 492 (1963).
Bradner, W. T., and M. H. Pindell: Antitumor properties of phleomycin. Nature 196, 682 (1962).
Cohen, M. M.: Specific effects of streptonigrin activity on human chromosomes in culture. Cytogenetics 2, 271 (1963).
Cohen, M. M., M. W. Shaw, and A. P. Craig: Effects of streptonigrin on cultured human leucocytes. Proc. Nati Acad. Sci. U.S. 50, 16 (1963).
Falaschi, A., and A. Kornberg: Phleomycin, an inhibitor of Dna polymerase. Federation Proc. 23, 940 (1964).
Georgien, G. P., O. P. Samarina, M. I. Lerman, M. N. Smirnov, and A. N. Severtzor: Biosynthesis of messenger and ribosomal Rna in the nucleochromosomal apparatus of animal cells. Nature 200, 1291 (1963).
Gray, G. D., G. W. Camiener, and B. K. Bhuyan: Nogalamycin effects in rat liver: Inhibition of tryptophan pyrolase induction and nucleic acid and protein biosynthesis. Cancer Research 26, 249 (1966).
Hochstein, P., J. Laozlo, and D. Miller: A unique dicoumarol-sensitive, nonphosphorylating oxidation of Dpnh and Tpnh catalyzed by streptonigrin. Biochem. Biophys. Research Commun. 19, 289 (1965).
Horvath, J., I. Gado, O. Kilian, and T. Six: The action of xanthomycin. Biochem. Pharmacol. 13, 938 (1964).
Kajiwara, K., U. H. Kim, and G. C. Mueller: Phleomycin, an inhibitor of replication of He La cells. Cancer Res. 26, 233 (1966).
Lerman, L. S.: Structural considerations in the interaction of Dna and acridines. J. Mol. Biol. 3, 18 (1961).
Levine, M., and M. Bothwick: Action of streptonigrin on bacterial Dna metabolism and on induction of phage production in lysogenic bacteria. Virology 21, 568 (1963).
Levine, M., and M. Bothwick: Action of streptonigrin on genetic recombinations between bacteriophages. Proc. XI Int. Congr. Genet., The Hague, Netherlands 1963.
Maeda, K., H. Kosaka, K. Yagishita, and H. Umezawa: A new antibiotic phleomycin. J. Antibiotics (Japan), Ser. A 9, 82 (1956).
Planelles, J. J., Y. V. Soloryeva, Z. N. Belova, A. B. Silaer, M. K. Ebert, N. P. Grachera, A. M. Kharitonora, A. E. Gosheva, and S. S. Akopyants: Aurantin — a complex antibiotic substance of the actinomycin group; its properties and results of clinical trials on various types of neoplasms. Acta Unio Intern. contra Cancrum 20, 297 (1964).
Radding, C. M.: Uptake of tritiated thymidine by K12 (d) induced by streptonigrin. Proc. XI Intern. Congr. Genet., The Hague, Netherlands 1963.
Rao, K. V., K. Biemann, and R. B. Woodward: The structure of streptonigrin. J. Am. Chem. Soc. 85, 2533 (1963).
Rao, K. V., and W. P. Cullen: Streptonigrin, an antitumor substance. I. Isolation and characterization. Antibiotics Ann., p. 953 (1960).
Rao, K. V., and W. H. Peterson: Xanthomycin A: production, isolation and properties. J. Am. Chem. Soc. 76, 1335 (1954).
Sazykin, Y. O., and G. N. Barisova: Effect of specific inhibitors on Rna synthesis dissociated from protein synthesis by bacteriostatic antibiotics. Federation Proc. (Transl. Suppl.) 23, 380 (1964).
Smith, C. G., W. Lummis, and J. E. Grady: An improved tissue culture assay. II. Cytotoxicity studies with antibiotics, chemicals and solvent. Cancer Research 19, 847 (1959).
Takita, T.: Studies on purification and properties of phleomycin. J. Antibiotics (Japan), Ser. A 12, 285 (1959).
Tanaka, N.: Effect of phleomycin on Dna of tumor origin. J. Antibiotics (Japan), Ser. A 18, 111 (1965).
Tanaka, N., H. Yamagnchi, and H. Umezawa: Mechanism of action of phleomycin, a tumor-inhibitory antibiotic. Biochem. Biophys. Research Commun. 10, 171 (1963).
Thorne, C. B., and W. H. Peterson: Xanthomycins A and B, new antibiotics produced by a species of streptomyces. J. Biol. Chem. 176, 413 (1948).
Ward, D. C., E. Reich, and I. H. Goldberg: Base specificity in the interaction of polynucleotides with antibiotic drugs. Science 149, 1259 (1965).
White, J. R., and H. White: Effect of intercellular redox environment on bactericidal action of mitomycin C and streptonigrin. Antimicrobial Agents and Chemotherapy, p. 495 (1964).
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Bhuyan, B.K. (1967). Phleomycin, Xanthomycin, Streptonigrin, Nogalamycin, and Aurantin. In: Gottlieb, D., Shaw, P.D. (eds) Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38439-8_14
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DOI: https://doi.org/10.1007/978-3-662-38439-8_14
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