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Antibiotics pp 173-180 | Cite as

Phleomycin, Xanthomycin, Streptonigrin, Nogalamycin, and Aurantin

  • B. K. Bhuyan

Abstract

Phleomycin was isolated from a culture of Streptomyces verticillius by Maeda et al. (1956). It is a water-soluble copper containing antibiotic complex and is effective against a variety of bacteria. The antibiotic can be freed of its copper by treatment with 8-hydroxy-quinoline and can regain its copper on addition of CuSO4. The copper-free phleomycin had almost the same antibacterial activity as the copper containing antibiotic except against mycobacteria, where the former was less active (Takita, 1959). Some of the chemical and biological properties of phleomycin are listed in Table 1.

Keywords

Minimum Inhibitory Concen Phenazine Methosulfate Antibiotic Complex Marginal Inhibition Improve Tissue Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bhuyan, B. K., and A. D. Dietz: Nogalamycin: Fermentation, taxonomic and biological studies, Antimicrobial Agents and Chemotherapy, p. 836 (1965).Google Scholar
  2. Bhuyan, B. K., and C. G. Smith: Differential interaction of nogalamycin with Dna of varying base composition. Proc. Natl Acad. Sci. U.S. 54, 566 (1965a).CrossRefGoogle Scholar
  3. Bitteva, M. B.: The taxonomic position of the actinomycete producing aurantin. Mikrobiologiya (Transi.) 31, 492 (1963).Google Scholar
  4. Bradner, W. T., and M. H. Pindell: Antitumor properties of phleomycin. Nature 196, 682 (1962).PubMedCrossRefGoogle Scholar
  5. Cohen, M. M.: Specific effects of streptonigrin activity on human chromosomes in culture. Cytogenetics 2, 271 (1963).PubMedCrossRefGoogle Scholar
  6. Cohen, M. M., M. W. Shaw, and A. P. Craig: Effects of streptonigrin on cultured human leucocytes. Proc. Nati Acad. Sci. U.S. 50, 16 (1963).CrossRefGoogle Scholar
  7. Falaschi, A., and A. Kornberg: Phleomycin, an inhibitor of Dna polymerase. Federation Proc. 23, 940 (1964).Google Scholar
  8. Georgien, G. P., O. P. Samarina, M. I. Lerman, M. N. Smirnov, and A. N. Severtzor: Biosynthesis of messenger and ribosomal Rna in the nucleochromosomal apparatus of animal cells. Nature 200, 1291 (1963).CrossRefGoogle Scholar
  9. Gray, G. D., G. W. Camiener, and B. K. Bhuyan: Nogalamycin effects in rat liver: Inhibition of tryptophan pyrolase induction and nucleic acid and protein biosynthesis. Cancer Research 26, 249 (1966).Google Scholar
  10. Hochstein, P., J. Laozlo, and D. Miller: A unique dicoumarol-sensitive, nonphosphorylating oxidation of Dpnh and Tpnh catalyzed by streptonigrin. Biochem. Biophys. Research Commun. 19, 289 (1965).CrossRefGoogle Scholar
  11. Horvath, J., I. Gado, O. Kilian, and T. Six: The action of xanthomycin. Biochem. Pharmacol. 13, 938 (1964).PubMedCrossRefGoogle Scholar
  12. Kajiwara, K., U. H. Kim, and G. C. Mueller: Phleomycin, an inhibitor of replication of He La cells. Cancer Res. 26, 233 (1966).PubMedGoogle Scholar
  13. Lerman, L. S.: Structural considerations in the interaction of Dna and acridines. J. Mol. Biol. 3, 18 (1961).PubMedCrossRefGoogle Scholar
  14. Levine, M., and M. Bothwick: Action of streptonigrin on bacterial Dna metabolism and on induction of phage production in lysogenic bacteria. Virology 21, 568 (1963).PubMedCrossRefGoogle Scholar
  15. Levine, M., and M. Bothwick: Action of streptonigrin on genetic recombinations between bacteriophages. Proc. XI Int. Congr. Genet., The Hague, Netherlands 1963.Google Scholar
  16. Maeda, K., H. Kosaka, K. Yagishita, and H. Umezawa: A new antibiotic phleomycin. J. Antibiotics (Japan), Ser. A 9, 82 (1956).Google Scholar
  17. Planelles, J. J., Y. V. Soloryeva, Z. N. Belova, A. B. Silaer, M. K. Ebert, N. P. Grachera, A. M. Kharitonora, A. E. Gosheva, and S. S. Akopyants: Aurantin — a complex antibiotic substance of the actinomycin group; its properties and results of clinical trials on various types of neoplasms. Acta Unio Intern. contra Cancrum 20, 297 (1964).Google Scholar
  18. Radding, C. M.: Uptake of tritiated thymidine by K12 (d) induced by streptonigrin. Proc. XI Intern. Congr. Genet., The Hague, Netherlands 1963.Google Scholar
  19. Rao, K. V., K. Biemann, and R. B. Woodward: The structure of streptonigrin. J. Am. Chem. Soc. 85, 2533 (1963).CrossRefGoogle Scholar
  20. Rao, K. V., and W. P. Cullen: Streptonigrin, an antitumor substance. I. Isolation and characterization. Antibiotics Ann., p. 953 (1960).Google Scholar
  21. Rao, K. V., and W. H. Peterson: Xanthomycin A: production, isolation and properties. J. Am. Chem. Soc. 76, 1335 (1954).CrossRefGoogle Scholar
  22. Sazykin, Y. O., and G. N. Barisova: Effect of specific inhibitors on Rna synthesis dissociated from protein synthesis by bacteriostatic antibiotics. Federation Proc. (Transl. Suppl.) 23, 380 (1964).Google Scholar
  23. Smith, C. G., W. Lummis, and J. E. Grady: An improved tissue culture assay. II. Cytotoxicity studies with antibiotics, chemicals and solvent. Cancer Research 19, 847 (1959).PubMedGoogle Scholar
  24. Takita, T.: Studies on purification and properties of phleomycin. J. Antibiotics (Japan), Ser. A 12, 285 (1959).Google Scholar
  25. Tanaka, N.: Effect of phleomycin on Dna of tumor origin. J. Antibiotics (Japan), Ser. A 18, 111 (1965).Google Scholar
  26. Tanaka, N., H. Yamagnchi, and H. Umezawa: Mechanism of action of phleomycin, a tumor-inhibitory antibiotic. Biochem. Biophys. Research Commun. 10, 171 (1963).CrossRefGoogle Scholar
  27. Thorne, C. B., and W. H. Peterson: Xanthomycins A and B, new antibiotics produced by a species of streptomyces. J. Biol. Chem. 176, 413 (1948).PubMedGoogle Scholar
  28. Ward, D. C., E. Reich, and I. H. Goldberg: Base specificity in the interaction of polynucleotides with antibiotic drugs. Science 149, 1259 (1965).PubMedCrossRefGoogle Scholar
  29. White, J. R., and H. White: Effect of intercellular redox environment on bactericidal action of mitomycin C and streptonigrin. Antimicrobial Agents and Chemotherapy, p. 495 (1964).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • B. K. Bhuyan

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