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Enzyme pp 424–438Cite as

Adenosine triphosphatase activity of mitochondria

3.6.1.4 ATP phosphohydrolase of mitochondria

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Part of the book series: Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse ((HOPPE-SEYLER,volume Teil C))

Abstract

It was shown a number of years ago that rat liver mitochondria contained an activity which can liberate inorganic phosphate from ATP1. Since then, numerous studies dealing with this mitochondrial ATPase activity have established that its action is different from that of other phosphatases. The extensive study of the mitochondrial ATPase activity has been motivated by the assumption that mitochondrial ATPase may be a part of the enzyme system involved in oxidative phosphorylation2–5.

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Abbreviations

ATP:

adenosine triphosphate

ATPase:

adenosine triphosphatase

ADP:

adenosine diphosphate

Pi:

orthophosphate

DNP:

2,4-dinitrophenol

Mw:

mitochondria

EDTA:

ethylenediaminetetraacetate

ITP:

inosine triphosphate

GTP:

guanosine triphosphate

UTP:

uridine triphosphate

CTP:

cytidine triphosphate

AMP:

adenosine 5′-monophosphate

Tris:

trishy droxy methyl -aminomethane

DPN and DPNH:

diphosphopyridine nucleotide, oxidized form and reduced form

FAD:

flavin adenine dinucleotide

FMN:

flavin mononucleotide

DOC:

deoxycholate

pCMB:

p-chloro-mercuribenzoate

DCPIP:

2,6-dichlorophenolindophenol.

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, University of Utah, Salt Lake City, Utah, USA

    Masahiro Chiga

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  1. Masahiro Chiga
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R. A. Alberty G. Bratfisch F. H. Bruns R. Caputto F. Chatagner M. Chiga R. Czok R. Ehrenreich W. Franke H. Gibian D. M. Greenberg H. Hanson W. Hasselbach O. Hoffmann-Ostenhof B. Kassell K. N. v. Kaulla A. S. Keston H. Kröger A. Lajtha M. Laskowski Sr. M. Laskowski Jr. F. Leuthardt S. Lissitzky R. Michel J. F. Morrison R. J. Peanasky G. Pfleiderer G. W. E. Plaut H. Reinauer H. Schievelbein G. Siebert I. Trautschold M. F. Utter H.-H. Weber H. Weil-Malherbe E. Werle

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Chiga, M. (1967). Adenosine triphosphatase activity of mitochondria. In: Alberty, R.A., et al. Enzyme. Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse, vol Teil C. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38359-9_9

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