Summary
In the development of pulmonary silicosis in rats studies on changes in the total, esterified, free cholesterol and phospholipids were made in lungs, liver and blood plasma over a period of 200 days. Total cholesterol, its fractions and phospholipid content increased with time in the lungs of silicotic animals. Histo-chemically sudanophilic materials were observed in the cytoplasm of pulmonary macrophages. Changes similar to those of lungs were not observed in liver and blood plasma, and it has been concluded that the increased lipid content of lungs during experimental pulmonary silicosis may be due to the localised degenerative action of silica on macrophages.
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Kaw, J.L., Gupta, G.S.D., Zaidi, S.H. (1971). Lung Lipids and Pulmonary Silicosis in Rats. In: Borbély, F., Eckhardt, R.E., Forssman, S., Goto, S., Holstein, E., Lederer, E. (eds) Internationales Archiv für Arbeitsmedizin / International Archives of Occupational Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38021-5_49
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DOI: https://doi.org/10.1007/978-3-662-38021-5_49
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