Summary
Rats were exposed to carbon disulphide in concentration of 1.5 to 1.8 mg/l over several months and during certain time periods part of the animals were fed 30 mg of nicotinic acid per day. In the serum cholesterol, phospholipids and triglycerides were determined in time intervals ranging from 30 to 300 days of exposure. An increased level of all lipids in serum due to CS2 exposure was found; that increase could be prevented by feeding the nicotinic acid. The hypolipemic effect was observed only within the treatment period. Advanced hyperlipaemia could be removed by nicotinic acid treatment without interrupting the exposure to carbon disulphide.
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Wrońska-Nofer, T. (1970). The Influence of Nicotinic Acid upon the Disturbances in Lipid Metabolism Caused by Carbon Disulphide in Rats. In: Borbély, F., Eckhardt, R.E., Forssman, S., Goto, S., Holstein, E., Lederer, E. (eds) Internationales Archiv für Arbeitsmedizin / International Archives of Occupational Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38021-5_40
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