Skip to main content

Part of the book series: Archives of Gynecology and Obstetrics ((AGYO))

  • 36 Accesses

Summary

Classification of male fertility disorders should take into account the cause and severity of a disturbance as well as its effect on the fertilizing capacity of spermatozoa. A reasonable approach is the analysis of sperm morphology according to the Düsseldorf classification, which is based on defects of spermatid differentiation. The kind and frequency of malformed spermatozoa allow conclusions about basic testicular and epididymal disorders, which will facilitate the detection of epididymal sperm motility disturbances and, therefore, initiation of causal treatment. The effect of inflammatory processes on fertility depends on the site of inflammation. In addition, the necessity for varicocele treatment can be determined more exactly under consideration of sperm morphology and hormonal tests. So far, irregular chromatin condensation as a cause of disturbed male fertility has not been attributed to genetic reasons, whereas microdeletions of the Y chromosome are increasingly being discussed. Both the role of oxygen radicals and the significance of environmental factors need to be investigated in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aitken RJ, Buckingham D, Harkiss D (1993) Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of a reactive oxygen species on human spermatozoa. J Reprod Fertil 97:441–450

    Article  CAS  PubMed  Google Scholar 

  • Glezerman M, Lunenfeld E, Potashnik G, Huleihel M, Soffer Y, Segal S (1993) Efficacy of kallikrein in the treatment of oligozoospermia and asthenozoospermia: a double blind trial. Fertil Steril 60:1052–1056

    CAS  PubMed  Google Scholar 

  • Haidl G (1994) Asthenozoospermie — ein multifaktorielles Symptom. Fortschr Med (in press)

    Google Scholar 

  • Haidl G, Schill W-B (1994a) Assessment of sperm chromatin condensation: an important test for prediction of IvF outcome. Arch Androl 32:263–266

    Article  CAS  PubMed  Google Scholar 

  • Haidl G, Schill W-B (1994b) When to treat varicocele. Acta Chir Acad Sei Hung (in press)

    Google Scholar 

  • Haidl G, Badura B, Hinsch KD, Ghyczy M, Gareiß J, Schill W-B (1993) Disturbances of sperm flagella due to failure of epididymal maturation and their possible relationship to phospholipids. Hum Reprod 8:1070–1073

    CAS  PubMed  Google Scholar 

  • Hofferbert S, Burfeind P, Hoyer-Fender S, Lange R, Haidl G, Engel W (1993) A homozygous deletion of 27 base pairs in the coding regions of the human outer dense fiber protein gene does not result in a pathologic phenotype. Hum Molec Gen 2:2167–2170

    Article  CAS  Google Scholar 

  • Hofmann N, Haider SG (1985) Neue Erkenntnisse morphologischer Diagnostik der Spermatogenesestörungen. Gynäkologe 18:70–80

    CAS  PubMed  Google Scholar 

  • Hofmann N, Hilscher B, Bierling C (1990) Quantitative Untersuchungen der Korrelation von Störungen der Chromatinkondensierung mit der Spermatozoenmorphologie. Fertilität 6:208–213

    Google Scholar 

  • Lange R, Michelmann HW, Engel W (1990) Chromosomale Ursachen der Infertilität beim Mann. Fertilität 6:17–28

    Google Scholar 

  • Schill W-B (1992) Faktoren von Seiten des Mannes. In: Käser O, Friedberg KG, Ober K, Thomsen K, Zander J (eds) Gynäkologie und Geburtshilfe, 2nd. edn. Thieme, Stuttgart, pp. 8,30–8,99

    Google Scholar 

  • Sharpe RM, Skakkebaek NE (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392–1395

    Article  CAS  PubMed  Google Scholar 

  • Van Steirteghem AC, Liu J, Joris H, Nagy Z, Janssenswillen C, Tournaye H, Derde MP, Van Assche E, Devroey PC (1993) Higher success rate by intracytoplasmic sperm injection than by subzonal insemination: report of a second series of 300 consecutive treatment cycles. Hum Reprod 8:1055–1060

    PubMed  Google Scholar 

  • Vogt P, Chandley AC, Hargreave TB, Keil R, Ma K, Sharkey A (1992) Microdeletions in interval 6 of the Y chromosome of males with idiopathic sterility point to disruption of AZF, a human spermatogenesis gene. Hum Genet 89:491–496

    CAS  PubMed  Google Scholar 

  • WHO (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. Fertil Steril 57:1289–1293

    Google Scholar 

  • Wolff H, Bezold G, Zebhauser M, Meurer M (1991) Impact of clinically silent inflammation on male genital tract organs as reflected by biochemical markers in semen. J Androl 12:331–334

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Haidl, G. (1994). New aspects of the aetiology of male fertility disorders. In: Verhandlungen der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe. Archives of Gynecology and Obstetrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-37814-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-37814-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-37106-0

  • Online ISBN: 978-3-662-37814-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics