The advantages of a gonadotropin releasing hormone agonist (leuprolide acetate) in conjunction with gonadotropins for controlled ovarian hyperstimulation in IVF and GIFT cycles
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Since the incorporation of gonadotropin releasing hormone agonists (GnRHa) in controlled ovarian hyperstimulation (COH) regimes with various combinations of gonadotropins, there is evidence that specific advantages are obtained from using these agonists in invitro fertilization (IVF) and gamete intrafallopian tube transfer (GIFT) procedures. There is evidence that the increased efficiency rate in terms of pregnancy per IVF & GIFT cycle initiated, stems largely, from a reduced treatment cycle cancellation rate prior to oocyte harvest due to a relative increase in follicle stimulating hormone (FSH) to luteinizing hormone (LH) concentration and the inhibition of a preovulatory LH rise, resulting in improved follicle growth, endocrine responses and more healthy oocytes available for fertilization.
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