Pathophysiologische Grundlagen

  • M. H. Birkhäuser
Part of the Archives of Gynecology and Obstetrics book series (AGYO)


Während der fertilen Phase stammt der überwiegende Anteil der Östrogenproduktion aus den Ovarien, die unter Kontrolle der hypophysären Hormone LH und FSH stehen. Die Rückkoppelung zu Hypothalamus und Hypophyse erfolgt durch die Steroide Östradiol und Progesteron sowie das follikuläre Eiweißhormon Inhibin. Bereits während der fertilen Phase werden jedoch auch aus Ovar und Nebennierenrinde stammende Androgene im „peripheren Kompartiment“ (vor allem Fettgewebe, Muskulatur, Haut) unter Kontrolle des Enzymes Aromatase zu Östrogenen umgewandelt (sogenannte periphere Aromatisierung).


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. H. Birkhäuser
    • 1
  1. 1.UniversitätsfrauenklinikBernSchweiz

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