Advertisement

Gen-Struktur und Gen-Expression

Das Hiihner-Lysozym-Gen
  • Günther Schütz
Part of the Verhandlungen der Gesellschaft deutscher Naturforscher und Ärzte book series (NATURFORSCHER, volume 111)

Abstract

In the chicken oviduct the synthesis of the egg-white proteins ovalbumin, conalbumin, ovomucoid and lysozyme is controlled by the female sex steroids. The steroid-controlled rate of synthesis of these proteins is closely correlated to the cellular concentration of the egg-white protein mRNAs. The accumulation of these mRNAs is achieved by a drecreased rate of degradation and an increased rate of synthesis. To understand the molecular mechanism that regulates the expression of this group of genes we have isolated the lysozyme and ovomucoid gene by gene-cloning. The structure and expression of the lysozyme gene has been studied.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Palmiter, R.D.: Cell 4, 189 (1975)PubMedCrossRefGoogle Scholar
  2. 2.
    Rosen, J., O’Malley, B.W., in: Biochemical Action of Hormones, Vol. 3, p. 271 (ed. G. Litwack ). New York: Academic Press 1975Google Scholar
  3. 3.
    Schimke, R.T., McKnight, G.S., Shapiro, D.J., in: ibid., p. 245Google Scholar
  4. 4.
    Hynes, N.E., et al.: Cell 11, 923 (1977)PubMedCrossRefGoogle Scholar
  5. 5.
    Groner, B., et al.: J. Biol. Chem. 252, 6666 (1977)PubMedGoogle Scholar
  6. 6.
    Hynes, N.E., et al.: Biochemistry 18, 616 (1979)PubMedCrossRefGoogle Scholar
  7. 7.
    Palmiter, R.D., Carey, N.H.: Proc. Nat. Acad. Sci. USA 71, 2357 (1974)CrossRefGoogle Scholar
  8. 8.
    Nguyen-Huu, M.C., et al.: ibid. 75, 686 (1978)Google Scholar
  9. Schütz, G., et al.: Cold Spring Harbor Symp. Quant. Biol. 42, 617 (1978)CrossRefGoogle Scholar
  10. 9.
    Swaneck, G.E., et al.: Proc. Nat. Acad. Sci. USA 76, 1049 (1979)CrossRefGoogle Scholar
  11. 10.
    Sippel, A.E., et al.: Nucl. Acids Res. 5, 3275 (1978)PubMedCrossRefGoogle Scholar
  12. 11.
    Lindenmaier, W., et al.: ibid. 7, 1221 (1979)Google Scholar
  13. 12.
    Nguyen-Huu, M.C., et al.: Proc. Nat. Acad. Sci. USA 76, 76 (1979)CrossRefGoogle Scholar
  14. 13.
    Lindenmaier, W., et al.: ibid. 76, 6196 (1979)Google Scholar
  15. 14.
    Jung, A., et al.: ibid. 77, 5759 (1980)Google Scholar
  16. 15.
    Cochet, M., et al.: Nature, 879 (1979)Google Scholar
  17. 16.
    Benoist, C., et al.: Nucl. Acids Res. 8, 127 (1979)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Günther Schütz
    • 1
  1. 1.Institut für Zell- und TumorbiologieDeutsches KrebsforschungszentrumHeidelbergDeutschland

Personalised recommendations