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Biochemische, funktionelle und morphologische Organveränderungen durch Beeinflussung des 5-Hydroxytryptamin-Stoffwechsels

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Ergebnisse der Allgemeinen Pathologie und Pathologischen Anatomie

Zusammenfassung

Überblickt man die stürmische Entwicklung, welche bei der Erforschung des 5-Hydroxytryptamins (5-HT) in den letzten Jahren eingesetzt hat, dann findet man als wesentlichste Ursache für das ungewöhnlich große Interesse an dieser Substanz die besonderen pharmakologischen Eigenschaften, das Vorkommen einer klinisch und pathologisch-anatomisch charakterisierten Stoffwechselstörung des 5-HT beim metastasierenden Carcinoid und nicht zuletzt die Möglichkeit, 5-HT in Körperflüssigkeiten und Geweben mit relativ einfachen Methoden exakt zu bestimmen. Auch die zur Zeit noch sehr umstrittenen Vorstellungen über die physiologische Bedeutung des 5-HT beruhen in der Hauptsache auf diesen drei Pfeilern: den pharmakologischen Eigenschaften, den klinischen Beobachtungen beim Carcinoidsyndrom und der Kenntnis des 5-HT-Gehaltes in verschiedenen Organen.

Aus der Abteilung für experimentelle Medizin der F. Hoffmann-La Roche & Co. A.-G., Basel.

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  1. G. Zbinden
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Editors and Affiliations

  1. Hannover, Deutschland

    P. Cohrs

  2. Münster i. W., Deutschland

    W. Giese

  3. Düsseldorf, Deutschland

    H. Meessen  & J. Schoenmackers  & 

  4. Strasbourg, France

    W. Florange

  5. Rio de janeiro, Brasil

    D. De Paola  & J. R. Da Silva  & 

  6. Nutley, USA

    G. Zbinden

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Zbinden, G. (1960). Biochemische, funktionelle und morphologische Organveränderungen durch Beeinflussung des 5-Hydroxytryptamin-Stoffwechsels. In: Cohrs, P., et al. Ergebnisse der Allgemeinen Pathologie und Pathologischen Anatomie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-36743-8_4

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  • DOI: https://doi.org/10.1007/978-3-662-36743-8_4

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