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Experimental Infections by Spirochaetas

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Erzeugung von Krankheitszuständen durch das Experiment

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Abstract

The order of Spirochaetales Buchanan (1918), comprises microorganisms which, according to Bergey’s Manual of Determinative Bacteriology, have the following characteristics:

“Slender, flexuous bodies, 6 to 500 microns in length, in the form of spirals with at least one complete turn. Some forms may show an axial filament, a lateral crista, or ridge, or transverse striations; otherwise there is no significant protoplasmic pattern. Smaller forms may have a lower refractive index than that of true bacteria, and therefore they can be seen only with darkfield illumination. Some forms take aniline dyes with difficulty; Giemsa’s stain is uniformly successful. Granules are formed in some species which are found in vector hosts. All forms are motile. In the true bacteria, motility is effected by flagella endowed with a lashing movement; however, no such structures exist among the spirochetes. Terminal projections, whether derived from the periplast or from the axial filament, may assist in the movements, and it is possible that the crista has a similar function, although neither of these structures can explain the violent motion of the spirochetes. This motility consists of a rapid whirling or spinning about the long axis, which activity drives the organism forward or backward, there being no anteroposterior polarity. In addition the spirochetes make violent, lashing movements, curling and uncurling their spirals. Multiplication is by transverse fission, no sexual cycle being known. Free-living, saprophytic and parasitic forms.”

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References

  • Addamiano, L., Babudieri, B.: Research on spirochaetal strains isolated in Jordan. Bull. Wld Hlth Org. 17, 483–485 (1957).

    CAS  Google Scholar 

  • Addamiano, L., Kasarov, L. B.: Metabolism of the lipoproteins of serum by leptospiras: degradation of the triglycerides. J. med. Microbiol. 2, 165–168 (1969a).

    PubMed  Google Scholar 

  • Addamiano, L., Kasarov, L. B.: Degradation of the phospholipids of the serum lipoproteins by Leptospirae. J. med. Microbiol. 3, 243–248 (1969b).

    Google Scholar 

  • Alexander, A. D., Wood, G., Yancey, F., Byrne, R. J., Yager, R. H.: Cross neutralization of leptospiral haemolysins from different serotypes. Infect, a. Immun. 4, 154–159 (1971).

    CAS  Google Scholar 

  • Arean, V. M.: Toxin production by Leptospira icterohaemorrhagiae. Am. J. vet. Res. 25, 836–843 (1964).

    PubMed  CAS  Google Scholar 

  • Ashe, W. F., Pratt Thomas, H. R., Kumpe, C. W.: Weil’s disease: a complete review of american literature and an abstract of world literature. Medicine (Baltimore) 20, 145–210 (1941).

    Google Scholar 

  • Austoni, M.: Problemi attuali in tema di terapia delia leptospirosi. Rass. Clin. Ter. 61, 191–207 (1962).

    PubMed  CAS  Google Scholar 

  • Austoni, M.: Therapie der Leptospirosen des Menschen. In: Leptospiren und Leptospirosen; Infektionskrankheiten und ihre Erreger, Bd. 1, S. I, 68–77. Jena: G. Fischer 1966.

    Google Scholar 

  • Babudieri, B.: Proposta di una nuova sistematica dell’ordine delle Spirochaetales. Atti VI. Congr. Internaz. Microbiol. Roma 5, 46–50 (1954).

    Google Scholar 

  • Babudieri, B.: Laboratory diagnosis of leptospirosis. Bull. Wld Hlth Org. 24, 45–58 (1959).

    Google Scholar 

  • Babudieri, B.: Discussions. In: II. Symp. Leptospirae and Leptospirosis in man and animals, Lublin. Pol. Akad. Nauk, Warszawa, 463 (1964).

    Google Scholar 

  • Babudieri, B.: Moderne metodiche per la diagnostica delle leptospirosi. II. Simp. Naz. delle Leptospirosi, Messina 1965. Ann. Sclavo 8, 473–478 (1966).

    Google Scholar 

  • Babudieri, B., Bianchi, L.: Untersuchungen über ein epidemisches Vorkommen der Reisfelderleptospirosis in der Provinz Pavia. Z. Immun. Forsch. 98, 37–75 (1940).

    Google Scholar 

  • Babudieri, B., Bocciarelli, D.: Ricerche di microscopia elettronica. II. Studio morfologico del genere Spironema. R. C. Ist. sup. Sanità 6, 305–314 (1943).

    Google Scholar 

  • Babudieri, B., Bocciarelli, D.: Electron microscope studies on relapsing-fever Spiro-chaetes. J. Hyg. (Lond.) 46, 438–439 (1948).

    CAS  Google Scholar 

  • Babudieri, B., Carlos, E. R., Carlos, E. T., Jr.: Pathogenic Leptospira isolated from Toad kidneys. In press. (Geogr. a. Trop. Med.).

    Google Scholar 

  • Babudieri, B., Zardi, O.: Studies on the metabolism of Leptospirae. I. Vitamin B12 as a growth factor. Z. Vitamin-, Hormon-u. Fermentforsch. 4, 299–309 (1961).

    Google Scholar 

  • Baermann, G., Halberstadter: Experimentelle Versuche über Framboesia tropica in Affen. Geneesk Tijdschr. Ned.-Ind. 40, 181 (1906).

    Google Scholar 

  • Balfour, A.: Trans. XVII. Int. Congr. Med., London, Sect. 21, Part 2, 275 (1914), quoted by Hinle, E. (1931).

    Google Scholar 

  • Bauer, D. C., Morse, E. V.: Variation and hemolysin production in relation to virulence of L. pomona. Proc. Soc. exp. Biol. (N.Y.) 98, 505–508 (1958).

    CAS  Google Scholar 

  • Beardmore, W. B., Dodd, M. C.: The growth of the Reiter strain of T. pallidum in the chick embryo. J. Bact. 60, 5–7 (1950).

    PubMed  CAS  Google Scholar 

  • Beclere, A.: Transmission expérimentale de la syphilis à l’espèce bovine. Ann. Inst. Pasteur 53, 23–42 (1934).

    Google Scholar 

  • Beitzke, H.: Über die pathologische Anatomie der ansteckenden Gelbsucht. Berl. klin. Wschr. 1, 188–199 (1916).

    Google Scholar 

  • Bergey’s Manual of determinative bacteriology, VIII. ed., Baltimore: Williams & Wilkins Co. 1957.

    Google Scholar 

  • Berlinghoff, W.: Die experimentelle Syphilis der weißen Maus. Derm. Wschr. 136, 929–931 (1957).

    PubMed  CAS  Google Scholar 

  • Bertakelli, E.: Sulla trasmissione della sifilide al coniglio. Riv. Igiene e San. Pubbl. 57, 646–660 (1906).

    Google Scholar 

  • Bertakelli, E.: Zbl. Bakt., I. Abt. Orig. 41, 320–326 (1906).

    Google Scholar 

  • Bertarelli, E.: Über die Empfänglichkeit der Fleischfresser (Hund) und der Wiederkäuer für experimentelle Syphilis. Zbl. Bakt., I. Abt. Orig. 43, 790–793 (1907).

    Google Scholar 

  • Bertok, L., Kemenes, F., Simon, G.: Fatal leptospirosis icterohaemorrhagica induced by ethionine in albino rats. J. Path. Bact. 88, 329–331 (1964).

    PubMed  CAS  Google Scholar 

  • Bessemans, A., Baert, H.: Réceptivité du furet à l’inoculation expérimentale de divers tréponèmes: palldoïdose inapparente chez la souris blanche. Rev. Belge Path. 25, 488 (1956).

    PubMed  CAS  Google Scholar 

  • Bessemans, A., Geest, B. de: Essais de culture “in vitro” du Tréponème pâle en symbiose avec du tissu testiculaire de lapin. Rev. Belge Sci. méd. 6, 28–36 (1934).

    Google Scholar 

  • Bessemans, A., Haequaert, R.: Quoted by Bessemans, A. Urol. cutan Rev. 34, 71–91 (1930).

    Google Scholar 

  • Bessemans, A., Meirsman, E. de: Tentatives de culture de Treponema pallidum sur ia membrane chorioallantoïdienne de l’embryon de poulet vivant. C. R. Soc. Biol. (Paris) 127, 847–848 (1938).

    Google Scholar 

  • Bessemans, A., Potter, F. de: Manifestation syphilitique primaire et transmissible chez la souris blanche. Syphilis apparente et inapparente. C. R. Soc. Biol. (Paris) 104, 818–820 (1930).

    Google Scholar 

  • Bessemans, A., Potter, F. de: Note complémentaire sur la syphilis apparente de la souris. C. R. Soc. Biol. (Paris) 107, 279–282 (1931).

    Google Scholar 

  • Bessemans, A., Wilde, H. de, Thielen, E. van: Syphilis inapparente du Macaque et résistance à la pallidoïdose. C. R. Soc. Biol. (Paris) 129, 373–376 (1938).

    Google Scholar 

  • Bosselut, R.: Sur un spirochaete sanguicole du chien domestique. Bull. Soc. Path. exot. 18, 702–704 (1925).

    Google Scholar 

  • Breinl, A., Kinghorn, A.: An experimental study of the parasite of the african tick-fever. Mem. L.pool Sch. Trop. Med. 21 (1906).

    Google Scholar 

  • Broom, J. C., Norris, T. St. M.: Failure of prophylactic oral penicillin to inhibit a human laboratory case of leptospirosis. Lancet 1957I, 721-722.

    Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. I. Primary infection in the testicle. J. exp. Med. 31, 475–498 (1920a).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. II. Primary infection in the scrotum. Part I. Reaction to infection. J. exp. Med. 31, 709–727 (1920b).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. II. Primary infection in the scrotum. Part 2. Scrotal lesions and the character of the scrotal infection. J. exp. Med. 31, 729–748 (1920c).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. III. Local dissemination, local recurrence, and involvement of regional lymphatics. J. exp. Med. 31, 749–764 (1920d).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. IV. Cutaneous syphilis. Part I. Affections of the skin and appendages. J. exp. Med. 32, 445–471 (1920e).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. IV. Cutaneous syphilis. Part 2. Clinical aspects of cutaneous syphilis. J. exp. Med. 32, 473–495 (1920f).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. V. Syphilitic affections of the mucous membranes and mucocutaneous borders. J. exp. Med. 32, 497–512 (1920g).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: A note on the dissemination of Spirochaeta pallida from the primary focus of infection. Arch. Derm. Syph. (Chic.) 2, 470–472 (1920h).

    Google Scholar 

  • Brown, W. H., Pearce, L.: Note on the preservation of stock strains of Treponema pallidum and on the demonstration of infection in rabbits. J. exp. Med. 34, 185–188 (1921a).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Experimental syphilis in the rabbit. VII. Affections of the eyes. J. exp. Med. 34, 167–181 (1921b).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L.: Latent infections, with the demonstration of Spirochaeta pallida in lymphoid tissues of the rabbit. Amer. J. Syph. 5, 1–8 (1921c).

    Google Scholar 

  • Brown, W. H., Pearce, L.: The influence of light on the reaction to infection in experimental syphilis. J. exp. Med. 45, 497–518 (1927).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L., Allen, C. M. van: Solar energy. The animal organism and susceptibility to disease. Trans. Ass. Amer. Physics 39, 251–355 (1924).

    Google Scholar 

  • Brown, W. H., Pearce, L., Witherbee, W. D.: Experimental syphilis in the rabbit. VI. Affections of bone, cartilage, tendons and synovial membranes. Part 1. Lesions of the skeletal system. J. exp. Med. 33, 495–514 (1921a).

    PubMed  CAS  Google Scholar 

  • Brown, W. H., Pearce, L., Witherbee, W. D.: Experimental syphilis in the rabbit. VI. Affections of bone, cartilage, tendons and synovial membranes. Part 2. Clinical aspects of the skeletal system. Affections of the facial and cranial bones and the bones of the forearm. J. exp. Med. 33, 512–523 (1921b).

    Google Scholar 

  • Buchanan, R. E.: Studies on the classification and nomenclature of the bacteria. X. Subgroups and genera of the mixobacteriales and spirochaetales. J. Bact. 3, 541–545 (1918).

    PubMed  CAS  Google Scholar 

  • Bykowa, O.: Über die Veränderung einiger blutbildender Organe bei Typhus recurrens. Virchows Arch. path. Anat. 260, 169–175 (1926).

    Google Scholar 

  • Callaway, J. L., Sharp, J.: Cultivation of Spirochaeta pallida on the chorioallantoic membrane of the developing hen egg. J. Lab. clin. Med. 27, 232–234 (1941).

    Google Scholar 

  • Castellani, A.: On the presence of spirochaetes in two cases of ulcerated parangi (yaws). Brit. med. J. 1905II, 1280.

    Google Scholar 

  • Castellani, A., Chalmers, A. J.: Manual of tropical medicine, 1st ed. London: Baillière, Tindall & Cox 1910.

    Google Scholar 

  • Chesney, A. M.: The influence of the factors of sex, age and method of inoculation upon the course of experimental syphilis in the rabbit. J. exp. Med. 38, 627–643 (1923).

    PubMed  CAS  Google Scholar 

  • Chesney, A. M., Kemp, J. E.: Studies in experimental syphilis. I. The influence of the size of the inoculum on the course of experimental syphilis in the rabbit. J. exp. Med. 41, 479 (1925).

    PubMed  CAS  Google Scholar 

  • Chesney, A. M., Schipper, G. J.: The effect of the method of inoculation upon the course of experimental syphilis in the rabbit. Amer. J. Syph. 34, 18–24 (1950).

    CAS  Google Scholar 

  • Coffey, E. M., Eveland, W. C.: Experimental relapsing fever initiated by Borrelia hermsi. I. Identification of major serotypes by immunofluorescence. J. infect. Dis. 117, 20 (1967).

    Google Scholar 

  • Coffin, D. L., Maestrone, D.: Detection of leptospirae by fluorescent antibody. Amer. J. vet. Res. 23, 159–164 (1962).

    PubMed  CAS  Google Scholar 

  • Coles, A. C.: Blood parasites found in mammals, birds and fishes in England. Parasitology 7, 17–61 (1914).

    Google Scholar 

  • Cox, C. D., Larson, A.D.: Colonial growth of Leptospirae. J. Bact. 73, 587–589 (1957).

    PubMed  CAS  Google Scholar 

  • De Lamater, E. D.: A study of the life-cycle of spirochaetes and other microorganisms by means of phase contrast and routine microscopy. Trans. N.Y. Acad. Sci. 14, 199–201 (1952).

    Google Scholar 

  • De Lamater, E. D., Newcomer, V. D., Haanes, M., Wiggall, R. H.: Studies on the life-cycle of spirochaetes. I. The use of phase contrast microscopy. Amer. J. Syph. 34, 122–125 (1950).

    Google Scholar 

  • Diesch, S. L., McCulloch, W. F., Braun, J. L., Ellinghausen, H. C, Jr.: Leptospires isolated from frog kidneys. Nature (Lond.) 209, 939 (1966).

    CAS  Google Scholar 

  • Dodd, S.: A preliminary note on the identity of the Spirochaeta found in the horse, ox and sheep. J. comp. Path. 19, 318–322 (1906).

    Google Scholar 

  • Eagle, H., Germuth, F. G.: Serologic relationships between five cultured strains of supposed T. pallidum (Noguchi, Kroö, Nichols, Reiter and Kazan) and two strains of mouth trepo-nemata. J. Immunol. 60, 223–239 (1948).

    PubMed  CAS  Google Scholar 

  • Ellinghausen, H. C. Jr., McCullough, W. G.: Nutrition of Leptospira pomona and growth of 13 other serotypes: A serum-free medium employing oleic albumin complex. Amer. J. vet. Res. 26, 39–44 (1965a).

    PubMed  CAS  Google Scholar 

  • Ellinghafsen, H. C., Jr., McCullough, W. G.: Nutrition of Leptospira pomona and growth of 13 other serotypes: Fractionation of oleic albumin complex and a medium of bovine albumin and polysorbate 80. Amer. J. vet. Res. 26, 45 (1965b).

    Google Scholar 

  • Ferris, D. H., Rhoades, H. E., Hansen, L. E., Galton, M., Mansfield, M. E.: Research into the nidality of Leptospira Ballum in campestral hosts, including the Hog-nosed Snake (Heterodon platyrhinys). Cornell Vet. 51, 405 (1961).

    PubMed  CAS  Google Scholar 

  • Ferris, H. W., Turner, T. B.: Comparative histology of yaws and syphilis in Jamaica. Arch. Path. 24, 707–737 (1937).

    Google Scholar 

  • Ferris, H. W., Turner, T. B.: Comparison of cutaneous lesions produced in rabbits by intra-cutaneous inoculation of spirochaetes from yaws and syphilis. Arch. Path. 26, 491–500 (1938).

    Google Scholar 

  • Foldvari, F.: The conduct of the Spirochaeta pallida in tissue explantations. Amer. J. Syph. 16, 145–154 (1932).

    Google Scholar 

  • Frazier, C. N., Bensel, A., Keuper, C. S.: Phenomena of disease in rabbits fed cholesterol and inoculated with Treponema pallidum. II. Infectivity of blood. Amer. J. Syph. 34, 453–459 (1950).

    CAS  Google Scholar 

  • Frazier, C. N., Bensel, A., Keuper, C. S.: Further observations on the duration of spiro-chaetemia in rabbits with asymptomatic syphilis. Amer. J. Syph. 36, 167–173 (1952).

    CAS  Google Scholar 

  • Gammel, J. A., Ecker, E. E.: The virulence of Spirochaeta pallida in culture. Arch. Derm. Syph. (Chic.) 23, 439–444 (1931).

    Google Scholar 

  • Gastinel, P., Collart, P., Dunoyer, F.: Étude sur le comportement du tréponème de Reiter en milieu pénicilliné. Ann. Inst. Pasteur 96, 381–401 (1959).

    CAS  Google Scholar 

  • Ginger, C. D., Katz, F. E.: Separation of relapsing fever spirochaetes from blood by DEAE cellulose anion exchanger. Trans. roy. Soc. trop. Med. Hyg. 64, 700 (1970).

    PubMed  CAS  Google Scholar 

  • Gonder, R.: Studien über die Spirochaete aus dem Blute von Vesperugo Kulii. Arb. Gesundh.-Amt Berlin 27, 406–413 (1908).

    Google Scholar 

  • Graetz, F., Delbanco, E.: Beiträge zum Studium der Histopathologie der experimentellen Kaninchensyphilis. Med. Klin. 10, 375, 420 (1914).

    Google Scholar 

  • Graetz, F., Delbanco, E.: Weitere Beiträge zum Studium der Histopathologie der experimentellen Kaninchensyphilis. Derm. Wschr. 58, 6–28 (1914).

    Google Scholar 

  • Gregoriew, P. S., Jarisheva, K. G.: The histologic structure of syphilitic lesions of rabbits. Amer. J. Syph. 12, 67–81 (1928).

    Google Scholar 

  • Haagen, E., Schlossberger, H.: Über das Verhalten von Spirochäten in der Gewebekultur. 1st Intern. Congr. Microbiol. Rep. 2, 105, Paris (1930).

    Google Scholar 

  • Haensell, P.: Vorläufige Mitteilung über Versuche von Impf syphilis der Iris und Cornea des Kaninchenauges. Albrecht v. Graefes Arch. Ophthal. 27, 93–100 (1881).

    Google Scholar 

  • Hallauer, C., Kuhn, H.: Dauerpassagen von Leptospira icterogenes und Spirochaeta pallida (Truffi) im Hühnerembryo. Z. Hyg. Infekt.-Kr. 124, 125–130 (1942).

    Google Scholar 

  • Hamdy, A. H., Ferguson, L. C.: Virulence of Leptospira pomona in hamsters and cattle. Amer. J. vet. Res. 18, 35 (1957).

    PubMed  Google Scholar 

  • Hardy, P. M., Nell, E. E.: Specific agglutination of Treponema pallidum by sera from rabbits and human beings with treponemal infection. J. exp. Med. 101, 367–382 (1955).

    PubMed  CAS  Google Scholar 

  • Hindle, E.: Blood spirochaetes. In: A system of bacteriology in relation to medicine, vol. 8, p. 147–184. London: Med. Res. Council 1931.

    Google Scholar 

  • Hoffmann, E., Bruning, W.: Gelungene Übertragung der Syphilis auf Hunde. Dtsch. med. Wschr. 33, 553 (1907).

    Google Scholar 

  • Hollander, D. H., Nell, E. E.: Improved preservation of T. pallidum and other bacteria by freezing with glycerol. Appl. Microbiol. 2, 164–170 (1954).

    PubMed  CAS  Google Scholar 

  • Hollander, D. H., Turner, T. B.: The role of temperature in experimental svphilis infection. Amer. J. Syph. 38, 489–505 (1954).

    CAS  Google Scholar 

  • Jordan, E. O., Burrows, W.: The spirochetes. In: Textbook of bacteriology, 14th ed., p. 671–699. Philadelphia: W. B. Saunders 1945.

    Google Scholar 

  • Kakishita, Saito: Spirochaeta pallida. J. infect. Dis. 19, 138 (1930).

    Google Scholar 

  • Kast, C. C., Kolmer, J. A.: On the cultivation of Spirochaeta pallida in living tissue media. Amer. J. Syph. 17, 529–532 (1933).

    Google Scholar 

  • Kast, C. C., Kolmer, J. A.: One successful cultivation of Spirochaeta pallida from syphilitic chancre of the rabbit. Amer. J. Syph. 17, 533–538 (1933).

    Google Scholar 

  • Kast, C. C., Kolmer, J. A.: Methods for the isolation and cultivation of tréponèmes, with special reference to culture media. Amer. J. Syph. 24, 671–683 (1940).

    Google Scholar 

  • Kast, C. C., Kolmer, J. A.: A note on the cultivation of Treponema pallidum with the preservation of virulence. Amer. J. Syph. 27, 309–313 (1943).

    Google Scholar 

  • Kato, N.: Lues 7, 71 (Quoted by Matsumoto, S., 1942).

    Google Scholar 

  • Kazar, J., Chorvath, B.: Prisperok k studin antigennej struktury hemolyzinie leptospir. Czech. Epidemiol. Microbiol. Immunobiol. 11, 353 (1962).

    CAS  Google Scholar 

  • Klarenbeek, A.: Recherches expérimentales avec un spirochète se trouvant spontanément chez le lapin et ressemblant au T. pallidum. Ann. Inst. Pasteur 35, 326–331 (1921).

    Google Scholar 

  • Klarenbeek, A.: Infection oculaire expérimentale du lapin par le Spirochaeta cuniculi. Ann. Inst. Pasteur 44, 201–207 (1930).

    Google Scholar 

  • Kmety, E., Plesko, I., Bakoss, P.: Leptospirosen im Tierexperiment. In: Leptospiren und Leptospirosen; Infektionskrankheiten und ihre Erreger, Bd. 1, S. I, 426–454. Jena: G. Fischer 1966.

    Google Scholar 

  • Kolle, W., Evers, E.: Experimentelle Untersuchungen über Syphilis-und Recurrens-Spirochaetose. III. Experimentelles über Syphilisinfektion ohne Symptome. Dtsch. med. Wschr. 52, 557–559 (1926).

    CAS  Google Scholar 

  • Kolle, W., Schlossberger, H.: Experimentelle Studien über Syphilis-und Recurrens-Spirochaetose. V. Über symptomlose Infektion von Mäusen und Ratten, sowie symptomlose Superinfektionen syphilitischer Kaninchen mit Spirochaeta pallida. Dtsch. med. Wschr. 52, 1245–1247 (1926).

    Google Scholar 

  • Lapidari, M., Sparrow, H.: Sur la culture des spirochètes des fièvres récurrentes. Arch. Inst. Pasteur Tunis 17, 191–205 (1928).

    Google Scholar 

  • Larson, C. L.: Susceptibility of young mice (Mus musculus) to L. icterohaemorrhagiae. Publ. Hlth Rep. (Wash.) 56, 1546–1556 (1941).

    Google Scholar 

  • Laveran, A.: Sur la spirillose de bovide. C. R. Acad. Sci. (Paris) 136, 939–941 (1903).

    Google Scholar 

  • Leishman, W. B.: Observations on the mechanism of infection in tick fever and on hereditary transmission of Spirochaeta duttoni in the tick. Trans. roy. Soc. trop. Med. Hyg. 3, 77–106 (1910).

    Google Scholar 

  • Leishman, W. B.: A note on the “granula clumps” found in African relapsing fever (tick fever). Ann. Inst. Pasteur 32, 49 (1918).

    Google Scholar 

  • Leony Blanco, F., Oteiza, A.: Sobre la transmission experimental de la pinta, mal del pinto o carate al conejo. Rev. méd.-soc. Sanid. 4, 11–15 (1944).

    Google Scholar 

  • Leony Blanco, F., Oteiza, A.: The experimental transmission of pinta, mal del pinto or carate, to the rabbit. Science 101, 309–311 (1945).

    Google Scholar 

  • Levaditi, C., Anderson, T. E.: Neurotropisme du Sp. duttoni. C. R. Acad. Sci. (Paris) 186, 653 (1928).

    Google Scholar 

  • Levaditi, C., Anderson, T. E.: L’état du virus de la fièvre récurrente (Spirochaeta duttoni) dans l’encéphale de la souris. C. R. Soc. Biol. (Paris) 100, 1121–1123 (1929).

    Google Scholar 

  • Levaditi, C., Marie, A., Isaicu, L.: Recherches sur la spirochétose spontanée du lapin. C. R. Soc. Biol. (Paris) 85, 51–54 (1921).

    Google Scholar 

  • Levaditi, C., Marie, A., Nicolau, S.: Virulence pour l’homme du spirochète de la spirillose spontanée du lapin. C. R. Acad. Sci. (Paris) 172, 1542–1543 (1921).

    Google Scholar 

  • Levaditi, C., Vaisman, A., Schoen, R.: L’état ou se trouve le virus syphilitique dans la névraxe des souris syphilisées, par voie sous-cutanée. C. R. Soc. Biol. (Paris) 112, 1669–1672 (1933).

    Google Scholar 

  • Levaditi, C., Yamanouchi, T.: La transmission de la syphilis au chat. C. R. Acad. Sci. (Paris) 146, 1120–1122 (1908).

    Google Scholar 

  • Listgarten, M. A., Socransky, S. S.: Electron microscopy of axial fibrils, outer envelope and cell division of certain oral spirochaetes. J. Bact. 88, 1087 (1964).

    PubMed  CAS  Google Scholar 

  • Logan, L. C., Cox, P. M.: Automated qualitative and quantitative micro-hemoagglutination assay for Treponema pallidum antibodies (AMHA-Tp). Provisional technique, modified October 20, 1970. Amer. J. clin. Path. 53, 163 (1970).

    CAS  Google Scholar 

  • Magnuson, H. J., Eagle, H., Fleishman, R.: The minimal infectious inoculum of Spirochaeta pallida (Nichols strain) and a consideration of its rate of multiplication “in vivo”. Amer. J. Syph. 32, 1–18 (1948).

    CAS  Google Scholar 

  • Magnuson, H. J., Rosenau, B. J., Greenberg, B. C.: The effects of sex, castration and testosterone upon the susceptibility of rabbits to experimental syphilis. Amer. J. Syph. 35, 146–163 (1951).

    CAS  Google Scholar 

  • Marchoux, E., Salimbeni, A.: La spirillose des poules. Ann. Inst. Pasteur 17, 569–580 (1903).

    Google Scholar 

  • Mason, H.C.: Avirulence of cultured Spirochaeta pallida. Urol. cutan. Rev. 43, 733–736 (1939).

    Google Scholar 

  • Mathis, C., Leger, M.: Spirochète du lapin. C. R. Soc. Biol. (Paris) 70, 212–214 (1919).

    Google Scholar 

  • Matsumoto, S.: Experimental syphilis and framboesia with special reference to the comparative pathology and immunity. Monographiae Actorum Dermatologicorum, Series B, Syphilidologica N° 3, Imperial University, Kyoto (1930).

    Google Scholar 

  • Matsumoto, S.: Experimentelle Syphilis und Framboesia, insbesondere die Frage ihrer Identität oder Dualität. Monographiae Actorum Dermatologicorum, Series B, Syphilidologica N° 10, Imperial University, Kyoto (1942).

    Google Scholar 

  • McLeod, C. P., Arnold, R. C.: A comparison of two methods of gland transfer in experimental syphilis. J. vener. Dis. Inform. 32, 96–99 (1951).

    PubMed  CAS  Google Scholar 

  • McLeod, C. P., Turner, T. B.: Studies on the biologic relationship between the causative agents of syphilis, yaws and venereal spirochaetosis of rabbits. I. Observations on Treponema cuniculi infection in rabbits. Amer. J. Syph. 30, 442–454 (1946a).

    Google Scholar 

  • McLeod, C. P., Turner, T. B.: Studies on the biologic relationship between the causative agents of syphilis, yaws and venereal spirochaetosis of rabbits. II. Comparison of the experimental disease produced in rabbits. Amer. J. Syph. 30, 455–462 (1946b).

    CAS  Google Scholar 

  • Metchnikoff, E., Roux, E.: Etudes expérimentales sur la syphilis. Ann. Inst. Pasteur 17, 809–821 (1903).

    Google Scholar 

  • Metchnikoff, E., Roux, E.: Etudes expérimentales sur la syphilis. Ann. Inst. Pasteur 18, 1–6, 657-671 (1904).

    Google Scholar 

  • Metchnikoff, E., Roux, E.: Etudes expérimentales sur la syphilis. Ann. Inst. Pasteur 19, 673–698 (1905).

    Google Scholar 

  • Metchnikoff, E., Roux, E.: Etudes expérimentales sur la syphilis. Ann. Inst. Pasteur 20, 785–800 (1906).

    Google Scholar 

  • Morton, H.: Susceptibility of Syrian hamsters to leptospirosis. Proc. Soc. exp. Biol. (N.Y.) 49, 566–568 (1942).

    Google Scholar 

  • Moulton, J. C., Howard, J. A.: The demonstration of Leptospira canicola in hamster kidneys by means of fluorescent antibody. Cornell Vet. 47, 424–432 (1957).

    Google Scholar 

  • Muehlens, P.: Rückfallfieber. In: Kolle, Kraus, Uhlenhuth, Handbuch der pathogenen Mikroorganismen, Bd. 7, S. 383–486. Jena-Berlin-Wien: G. Fischer und U. Schwarzen-berg 1930.

    Google Scholar 

  • Neisser, A.: Bericht über die unter finanzieller Beihilfe des deutschen Reiches während der Jahre 1905–1909 in Batavia und Breslau ausgeführten Arbeiten zur Erforschung der Syphilis. Berlin: Springer 1911.

    Google Scholar 

  • Nichols, H. J.: Experimental yaws in the monkey and rabbit. J. exp. Med. 12, 616–622 (1910).

    PubMed  CAS  Google Scholar 

  • Nichols, H. J.: Observations on a strain of Spirochaeta pallida isolated from the nervous system. J. exp. Med. 19, 362–371 (1914).

    PubMed  CAS  Google Scholar 

  • Nicolle, C.: Sur une piroplasmose nouvelle d’un ronger. C. R. Soc. Biol. (Paris) 63, 213–214 (1907).

    Google Scholar 

  • Nicolle, C., Anderson, C., Colas-Belcour, J.: Sur un noveau spirochaete sanguicole patogene (Sp. normandi) trasmis par un Ornithodore (O. normandi) hôte des terriers de rongeurs nord africaines. C. R. Acad. Sci. (Paris) 185, 344–336 (1927).

    Google Scholar 

  • Nicolle, C., Comte, C.: Sur une spirillose d’un cheiroptère (V. kuhli). C. R. Soc. Biol. (Paris) 59, 200 (1905).

    Google Scholar 

  • Nicolle, C., Comte, C.: Sur une spirillose d’un cheiroptère (V. kuhli). Ann. Inst. Pasteur 20, 311–320 (1906).

    Google Scholar 

  • Nikolaiew, J. J., Ananjin, V. V.: Leptospiros u miscei. Vopr. Kraevoi obscei experim. parasit. i mediz. zool. 7, 217–221 (1951).

    Google Scholar 

  • Noguchi, H.: A method for the pure cultivation of pathogenic Treponema pallidum (Spirochaeta pallida). J. exp. Med. 14, 99–108 (1911).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Cultural studies in mouth spirochaete (T. microdentium and macrodentium). J. exp. Med. 15, 81–89 (1912a).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Pure cultivation of Spirochaeta refringens. J. exp. Med. 15, 466–469 (1912b).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Treponema mucosum (new species). A mucin producing spirochaete from pyorrhoea alveolaris, grown in pure culture. J. exp. Med. 16, 194–198 (1912c).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: The pure cultivation of Spirochaeta duttoni, Spirochaeta Kochi, Spirochaeta Obermeieri, and Spirochaeta Novyi. J. exp. Med. 16, 199–210 (1912d).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Pure cultivation of Spirochaeta phagedenis (new species), a spiral organism found in phagedenic lesions on human external genitalia. J. exp. Med. 16, 261–268 (1912e).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: A method for cultivating Treponema pallidum in fluid media. J. exp. Med. 16, 211–215 (1912f).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Cultivation of Treponema calligyrum (new species) from condylomata of man. J. exp. Med. 17, 89–98 (1913).

    PubMed  CAS  Google Scholar 

  • Noguchi, H.: Certain alterations in biological properties of spirochaetes through artificial cultivation. Ann. Inst. Pasteur 30, 1–4 (1916).

    Google Scholar 

  • Noguchi, H.: A note on the venereal spirochaetosis of rabbits: a new technique for staining Treponema pallidum. J. Amer. med. Ass. 77, 2052 (1921).

    Google Scholar 

  • Novy, F. G., Knapp, R. E.: Studies on Spirillum Obermeieri and related organisms. J. infect. Dis. 3, 291–293 (1906).

    Google Scholar 

  • Obermeier, O.: Vorkommen feinster, eine Eigenbewegung zeigender Fäden im Blute von Rekurrens-Kranken. Klin. Wschr. 152, 378, 391, 455 (1873).

    Google Scholar 

  • Ostertag, H.: Leptospirosis icterohaemorrhagica in Bulgarien. Z. Hyg. 131, 482–500 (1950).

    CAS  Google Scholar 

  • Otsuji: Lues 18, 153 (1938) (Quoted by Matsumoto, 1942).

    Google Scholar 

  • Otsuji: Lues 19, 31 (1939) (Quoted by Matsumoto, 1942).

    Google Scholar 

  • Otsuji: Lues 20, 71 (1939) (Quoted by Matsumoto, 1942).

    Google Scholar 

  • Ovchinnikov, H. M.: Experimental syphilis. Moscow: Medgiz [in Russian] 1955.

    Google Scholar 

  • Pautrizel, R., Mayer, G., Rivasseau-Coutant, A., Szersnovicz, F.: Immunité naturelle du foetus de lapin vis-à-vis de Treponema pallidum. Rev. Immunol. (Paris) 21, 383–392 (1957).

    CAS  Google Scholar 

  • Pearce, L., Brown, W. H.: Distinctive characteristics of infections produced by Treponema pertenue in the rabbit. J. exp. Med. 41, 673–690 (1925).

    PubMed  CAS  Google Scholar 

  • Perry, W. L. M.: The cultivation of Treponema pallidum in tissue culture. J. Path. Bact. 60, 339–342 (1948).

    PubMed  CAS  Google Scholar 

  • Plaut, F.: Untersuchungen über die Rolle der Milz für die Aufrechterhaltung der isolierten Gehirnspirochätose bei Recurrensratten. Klin. Wschr. 7, 301–303 (1928).

    Google Scholar 

  • Plimmer, H. G.: Proc. Zool. Soc. London part 2, 406 (1912) (Quoted by Hindle, E., 1931).

    Google Scholar 

  • Raiziss, G. W., Severac, M.: Rapidity with which Spirochaeta pallida invades the blood stream. Arch. Derm. Syph. (Chic.) 35, 1101–1109 (1937).

    Google Scholar 

  • Ranken, H. S.: A note on “granule-shedding” in T. pertenue. Brit. med. J. 1912I, 1482.

    Google Scholar 

  • Reasoner, M. A.: Some phases of experimental syphilis with special reference to the question of strains. J. Amer. med. Ass. 67, 1799–1805 (1916).

    Google Scholar 

  • Resseler, R., Riel, M. van: Conservation des leptospires après refroidissement ou lyophiliza-tion. Intern. Colloq. on Leptospirosis, Antwerpen, 1965. Ann. Soc. Belge Méd. Trop. 46, 213–222 (1966).

    CAS  Google Scholar 

  • Rosahn, P. D.: The reaction of standard breeds of rabbits to experimental syphilis. J. exp. Med. 57, 907–923 (1933).

    PubMed  CAS  Google Scholar 

  • Rosahn, P. D.: The adverse influence of syphilitic infection on longevity of mice and men. Arch. Derm. Syph. (Chic.) 36, 17–37 (1952).

    Google Scholar 

  • Rosahn, P. D., Gueft, B., Rowe, C. L.: Experimental mouse syphilis. I. Organ distribution of the infectious agent. Recent Advances in the study of Venereal Diseases; a Symposium, Washington D.C., p. 36-48, VD Education Inst., USPHS, Raleigh N.C. (1948).

    Google Scholar 

  • Rosahn, P. D., Rowe, C. L.: Experimental mouse syphilis. II. Minimal infectious number of Treponema pallidum. Amer. J. Syph. 34, 40–44 (1950).

    CAS  Google Scholar 

  • Ross, E.H.: An intracellular parasite developing into spirochaetes. Brit. med. J. 1912II, 1651-1654.

    Google Scholar 

  • Saenz, B., Grau Triana, J., Alfonso Armenteros, J.: Demonstration de un Treponema en el borde activo de un caso de pinta de las manos y pies y en la linfa de ganglios super-ficiales (reporte preliminar). Arch. med. internat. 4, 112–117 (1938).

    Google Scholar 

  • Sakharoff, M. N.: Spirochaeta anserina et septicémie des oies. Ann. Inst. Pasteur 5, 564–566 (1891).

    Google Scholar 

  • Savini, E.: Infection trypano-spirochetique. C. R. Soc. Biol. (Paris) 88, 956–958 (1923).

    Google Scholar 

  • Schamberg, J. F., Rule, A.M.: Therapeutic effect of hot baths in experimental syphilis. J. Amer. med. Ass. 88, 1217–1218 (1927).

    Google Scholar 

  • Schamberg, J. F., Rule, A. M.: The effect of extremely hot baths in experimental syphilis; further studies. Arch. Derm. Syph. (Chic.) 17, 322–331 (1928).

    Google Scholar 

  • Schaudinn, F.: Zur Kenntnis der Spirochaeta pallida. Dtsch. med. Wschr. 31, 1665–1667 and 1728 (1905).

    Google Scholar 

  • Schaudinn, F., Hoffmann, E.: Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsproducten und bei Papillomen. Arb. Gesundh.-Amt 22, 527–534 (1905).

    Google Scholar 

  • Schereschewsky, J.: Züchtung der Spirochaete pallida (Schaudinn). Dtsch. med. Wschr. 35, 835 (1909).

    Google Scholar 

  • Schereschewsky, J.: Weitere Mitteilung über die Züchtung der Spirochaeta pallida. Dtsch. med. Wschr. 35, 1260–1261 (1909).

    Google Scholar 

  • Schereschewsky, J.: Bisherige Erfahrungen mit der gezüchteten Spirochaeta pallida. Dtsch. med. Wschr. 35, 1652–1654 (1909).

    Google Scholar 

  • Schereschewsky, J.: Geschlechtlich übertragbare originäre Kaninchensyphilis und Chinin-Spirochätotropie. Berl. klin. Wschr. 57, 1142–1144 (1920).

    Google Scholar 

  • Schereschewsky, J.: Pallidakultur und Immunodiagnostik der Syphilis. Haut. Gesundh. 17, 233–236 (1954).

    CAS  Google Scholar 

  • Schlossberger, H.: Syphilis und Framboesie bei Mäusen. Zbl. Bakt., I. Abt. Orig. 104, 237-239(1927).

    Google Scholar 

  • Schlossberger, H.: Über das Verhalten der Syphilisspirochäten im Mäuseorganismus bei Passagen. Med. Klin. 25, 307–308 (1929).

    Google Scholar 

  • Schoebl, O.: Experimental yaws in Philippine monkeys and a critical consideration of our knowledge concerning framboesia tropica in the light of recent experimental evidence. Philipp. J. Sci. 35, 209–332 (1928).

    Google Scholar 

  • Scientific Group on Treponematoses Research, WHO: Treponema pallidum. WHO/VDT/ Res/8, Geneva (1961).

    Google Scholar 

  • Shaffer, L. W.: Cultural methods for increasing the number of Spirochaeta pallida in fresh syphilitic tissue. Arch. Path. Lab. Med. 2, 50–58 (1926).

    Google Scholar 

  • Sheldon, W. H.: Leptospiral antigen demonstrated by the fluorescent antibody technic in human muscle lesions of Leptospirosis icterohaemorrhagiae. Proc. Soc. exp. Biol. (N.Y.) 84, 165–167 (1953).

    CAS  Google Scholar 

  • Smith, H.: The use of bacteria grown in vivo for studies on the basis of their pathogenicity. Amer. Rev. Microb. 12, 77–102 (1958).

    CAS  Google Scholar 

  • Smith, H.: Studies on organisms grown in vivo to reveal the bases of microbial pathogenicity. Ann. N.Y. Acad. Sci. 88, 1213–1226 (1960).

    CAS  Google Scholar 

  • Stalheim, O. H. V.: Leptospiral selection growth, and virulence in synthetic medium. J. Bact. 92, 946 (1966).

    PubMed  CAS  Google Scholar 

  • Sterzi, G., Staudacher, V.: Tentativi di coltura della spirocheta di Schaudinn sulla mem-brana chorionallantoidea di embrione di polio vivente. G. ital. Derm. Sif. 80, 777–783 (1939).

    Google Scholar 

  • Stuart, R. D.: The preparation and use of a simple culture medium for leptospirae. J. Path. Bact. 58, 343 (1946).

    PubMed  CAS  Google Scholar 

  • Swain, R. H. A., Anderson, N.: The ultrastructure of Treponemas and Borreliae. In: The fine morphology of Spirochaetas, edited by B. Babudieri. Roma: Leonardo ediz. scientif. 1972.

    Google Scholar 

  • Tani, T., Kakishita, M., Saito, K.: Beiträge zur Meerschweinchensyphilis. Zbl. Bakt., I. Orig. 117, 73–81 (1930).

    Google Scholar 

  • Tarasevich, M. N., Bulke, B. F., Mudrova, P. L.: A method of conservation of pathogenic Leptospira organisms while preserving their virulence. J. Hyg. Epidem. (Praha) 7, 352–359 (1963).

    CAS  Google Scholar 

  • Terzin, A. L.: Leptospiral antigens for use in complement fixation. J. Immunol. 76, 366–372 (1956).

    PubMed  CAS  Google Scholar 

  • Theiler, A.: Spirillosis of cattle. J. C. Path. a. Ther. 17, 47–55 (1904)

    Google Scholar 

  • Theiler, A.: Spirillosis of cattle. J. Th. Veter. 1, 421–431 (1906).

    Google Scholar 

  • Theiler, A.: Transmission and inoculability of Sp. theileri. Proc. roy. Soc. B 76, 504–506 (1905).

    Google Scholar 

  • Thiel, P. H. van: Immunisatie gegen de ziekte van Weil met levende avirulente leptospirae. Geneesk. T. Ned.-Ind. 78, 1859–1874 (1938).

    Google Scholar 

  • Thiroux, A., Dufotjgere, W.: Persistance de l’infection des méninges chez un singe guéri, sans médication, d’une infection sanguine à Spirilles naturelle. Bull. Soc. Path. exot. 3, 23–24 (1910).

    Google Scholar 

  • Tomasczewski, E.: Über eine einfache Methode, bei Kaninchen Primäreffekte zu erzeugen. Dtsch. med. Wschr. 36, 1025 (1910).

    Google Scholar 

  • Tomioka, Y.: Experimenteller Beitrag zur Frage der Immunität bei Recurrens und ihre Beeinflussung durch die Salvarsantherapie. Zbl. Bakt., I. Abt. Orig. 92, 41 (1924).

    Google Scholar 

  • Tomizawa, T., Kasamatsu, S.: Haemagglutination tests for diagnosis of syphilis. A preliminary report. Jap. J. med. Sci. Biol. 19, 305 (1966).

    PubMed  CAS  Google Scholar 

  • Truffi, M.: Über die Übertragung eines menschlichen syphilitischen Primäraffektes auf die Haut des Kaninchens. Zbl. Bakt., I. Abt. Orig. 48, 597–599 (1909).

    Google Scholar 

  • Turner, T. B.: The preservation of virulent T. pallidum and T. pertenue in the frozen state: with a note on the preservation of the filtrable viruses. J. exp. Med. 67, 61–78 (1938).

    PubMed  CAS  Google Scholar 

  • Turner, T. B., Fleming, W. J.: Prolonged maintenance of spirochaetes and filtrable viruses in the frozen state. J. exp. Med. 70, 620–637 (1939).

    Google Scholar 

  • Turner, T. B., Holander, D. H.: Cortisone in experimental syphilis-a preliminary note. Bull. Johns Hopk. Hosp. 87, 505–509 (1950).

    CAS  Google Scholar 

  • Turner, T. B., Holander, D. H.: Studies on the mechanism of action of cortisone in experimental syphilis. Amer. J. Syph. 38, 371–387 (1954).

    CAS  Google Scholar 

  • Turner, T. B., Holander, D. H.: Biology of the treponematoses. Wld Hlth Org. Monogr. Ser. No 35 (1957).

    Google Scholar 

  • Uhlenhuth, P., Mulzer, P.: Beiträge zur experimentellen Pathologie und Therapie der Syphilis mit besonderer Berücksichtigung der Impf-Syphilis der Kaninchen. Arb. Gesundh.-Amt 44, 307–530 (1913).

    Google Scholar 

  • Volosceanu, D. I., Oprescu, C. C., Voiculescu, R.: Contributions to the study of strains of T. pallidum isolated in Roumania. Problems in Therapeutica III, 19–29 (1955).

    Google Scholar 

  • Warfolomeeva, A.A.: Young rabbits as a laboratory model for leptospirosis. In: Lepto-spirae and leptospirosis in man and animals. Pol. Akad. Nauk, Warsawa 18-21 (1960).

    Google Scholar 

  • Warfolomeeva, A. A.: Leptospiroses in USSR and their specific prophylaxis and treatment. In: Leptospirae and leptospirosis in man and animals. Pol. Akad. Nauk, Warsawa 197-210 (1960).

    Google Scholar 

  • Warfolomeeva, A. A.: Specific therapy in leptospirosis. II. Symp. on Leptospirae and leptospiroses in man and animals. Pol. Akad. Nauk, Warsawa, 377-380 (1964).

    Google Scholar 

  • Warthin, A. S.: Myxoma-like growths in the heart, due to localization of Spirochaeta pallida. J. infect. Dis. 19, 138 (1916).

    Google Scholar 

  • Weichbrodt, R., Jahnel, F.: Einfluß hoher Körpertemperaturen auf die Spirochaeten und Krankheitserscheinungen der Syphilis im Tierexperiment. Dtsch. med. Wschr. 45, 483–484 (1919).

    Google Scholar 

  • White, F. H., Ristic, M.: Detection of Leptospira pomona in guinea-pig and bovine urine with fluoresceinlabeled antibody. J. infect. Dis. 105, 118–123 (1959).

    PubMed  CAS  Google Scholar 

  • W.H.O. Treponematoses research, techn. Rep. Ser. Geneva (1970).

    Google Scholar 

  • WHO Expert Group: Current problems in leptospirosis research. Wld Hlth Org. techn. Rep. Ser. No 380 (1967).

    Google Scholar 

  • Wile, U. J., Johnson, S. A. M.: Experimental syphilis in the golden hamster. Amer. J. Syph. 29, 418–422 (1945).

    Google Scholar 

  • Wilson, G. S., Miles, A. A.: The Spirochaetes. In: Topley and Wilson’s Principles of bacteriology and immunity, 4th ed. London: E. Arnold, p. 1031-1056, and Syphilis, rabbit syphilis, yaws and pinta, p. 2027-2044 (1955).

    Google Scholar 

  • Wolff, J. W.: The laboratory diagnosis of leptospirosis. Springfield (Ill.) USA: Ch. C. Thomas 1954.

    Google Scholar 

  • Yamamoto, T.: Studien über Spirochätenfärbung. I. Untersuchung der pallidafärbenden Farbstoffe. Acta Derm. (Kyoto) 13, 591 (1929).

    Google Scholar 

  • Yamamoto, T.: Studien über Spirochätenfärbung. III. Färberische Unterschiede zwischen Sp. pallida, Sp. pallidula und 8p. cuniculi. Acta derm. (Kyoto) 14, 145 (1929).

    Google Scholar 

  • Zardi, O.: Influenza della terapia cortisonica e corticotropa nell’infezione sperimentale da leptospire. R. C. Ist. sup. Sanità 19, 188–195 (1956).

    CAS  Google Scholar 

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  1. B. Babudieri
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Editors and Affiliations

  1. Istituto Superiore di Sanita, Viale Regina Elena, 299, I-00161, Roma, Italien

    Brenno Babudieri

  2. Hygiene-Institut der Universität, 7400, Tübingen, Silcherstr. 7, Deutschland

    Richard-Ernst Bader (Direktor), Uwe Ullmann (Wiss. Assistent) & Hildegard Winkler (Akad. Oberrätin) (Direktor),  (Wiss. Assistent) &  (Akad. Oberrätin)

  3. Institut für Medizinische Mikrobiologie, Immunologie der Universität, 5300, Bonn-Venusberg, Deutschland

    Herbert Werner

  4. Pharmakologisches Institut der Universität, 6900, Heidelberg, Hauptstraße 47-51, Deutschland

    Oskar Eichler

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Babudieri, B. (1973). Experimental Infections by Spirochaetas. In: Babudieri, B., Bader, RE., Ullmann, U., Werner, H., Winkler, H., Eichler, O. (eds) Erzeugung von Krankheitszuständen durch das Experiment. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-36736-0_1

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