Abstract
The first attempts to use asparaginase in patients were reported by De Barros in 1965 [2] and by Dolowy et al. in 1966 [4]. These investigators used enzyme-containing fractions of the sera of agoutis and guinea pigs respectively. They noted a slight antitumor effect in one case of melanoma and one case of acute lymphoblastic leukemia. Complete remissions of acute lymphoblastic leukemia in patients treated with E. coli asparaginase were first reported by Hill et al. [7] and Oettgen et al. in 1967 [10].
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References
Burchenal, J. H., Karnofsky, D. A., Murphy, M. L., Oettgen, H.F.: Effects of L-Asparaginase on Leukemias and other Neoplasms. XIIth Congress. International Soc. Hemat. New York 1968.
Cacciola, E., Ferranto, A.: Presence of antiheparin in activity in leukemic cells. Boll. Soc. ital. Sper. 36, 1317 (1968).
De Barros, T.: Utilizacao de L-Asparagina em patiente humano portador de neoplasia maligna. An. Fac. Med. Recife. 25, 21 (1965).
Deutsch, E.: Discussion at the Internationale Arbeitstagung über Chemo-und Immuntherapie der Leukosen und malignen Lymphome. Wien/Austria, March 1969.
Dolowy, W. C., Henson, D., Cornet, J., Sellin, H.: Toxic and antinoplastic effects of L-asparaginase. Cancer. 19, 1813 (1966).
Gallmeier, W. M., Schmidt, C. G., Stier, H. W.: In-vitro-Testung von Zellen auf Asparaginmangelempfindlichkeit in Chemo-und Immunotherapie der Leukosen und malignen Lymphome. Hrsg. A. Stacher. Wien: Bohmann Verlag 1969, p. 30.
Haskell, C. M., Canellos, G. P., Leventhal, B. G., Carbone, P. P., Serpick, A. A., Hansen, H. H.: L-asparaginase toxicity. Cancer Res. 29, 974 (1969).
Hill, J. M., Roberts, J., Loeb, E., Khan, A., McLettan, A., Hill, R. W.: L-asparaginase therapy for leukemia and other malignant neoplasma. J. Amer. med. Ass. 202, 882 (1967).
Horowitz, B., Madras, B. K., Meister, A., Old, J. J., Boyse, E. A., Stockert, E.: Asparagin synthetase activity of mouse leukemias. Science. 160, 533 (1968).
Mathé, G., Amiel, J. L., Schwarzenberger, L., Schneider, M., Cattan, A., Schlumberger, J. R., Hayat, M., de Vassal, F., Jasmin, J., Rosenfeld, S.: Essai de traitement de la leucémie aiguë lymphoblastique par la L-asparaginase. Presse méd. 77, 461 (1965).
Oettgen, H. F., Old, L. J., Boyse, E. A., Campbell, H. A., Philips, F. S., Clarkson, B. D., Talal, L., Leeper, K. D., Schwartz, M. K.: Inhibition of leukemias in man by L-asparaginase. Cancer Res. 27, 2619 (1967).
Oettgen, H. F., Schulten, H. K.: Hemmung maligner Neoplasien des Menschen durch L-Asparaginase. Klin. Wschr. 47, 65 (1969).
Oettgen, H. F.: Paper presented at the meeting of the Paul-Ehrlich-Gesellschaft Wuppertal — Asparaginase-Therapie der Leukämien. May 1969.
Schmidt, C. G., Gallmeier, W.: Zur Enzymtherapie der Leukämien. Dtsch. med. Wschr. 93, 2299 (1968).
Stier, H. W., Schmidt, C. G., Gallmeier, W. M.: Das Blutgerinnungssystem während der Leukämiebehandlung mit L-Asparaginase in Chemo-und Immuntherapie der Leukosen und malignen Lymphome. Hrsg.: A. Stacher. Wien: Bohmann Verlag 1969, p. 310.
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Schmidt, C.G., Gallmeier, W.M., Stier, H.W. (1970). Clinical Status of L-Asparaginase and Side Effects. In: Mathé, G. (eds) Advances in the Treatment of Acute (Blastic) Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 30 . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35334-9_8
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DOI: https://doi.org/10.1007/978-3-662-35334-9_8
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