Abstract
The original discovery of the antileukemic effects of guinea pig serum by Kidd [1] in 1953 and the subsequent biological and chemical studies on its active principle, L-asparaginase (A-ase), by many investigators including Broome [2], Mashburn and Wriston [3], and Old, Boyse et al. [4, 5] are well known. Following the preliminary clinical studies on A-ase reported by De Barros et al. [6], Dolowy et al. [7], Hill et al. [8], and Oettgen et al. [9], we have been evaluating the drug for the past 2 years [10, 11].
These studies were supported in part by National Cancer Institute Grants CA-08748 and CA-05826 and American Cancer Society Grant T-45.
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References
Kidd, J. G.: Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum. J. exp. Med. 98, 565–581 (1953).
Broome, J. D.: Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance. J. exp. Med. 118, 99–120 (1963).
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— Dollinger, M. R.: L-asparaginase in transplanted mouse leukemia. International Society of Hematology, XIIth Congress (New York 1968), Abstracts of the Simultaneous Sessions, p. 6.
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Burchenal, J.H. (1970). Clinical Evaluation and Future Prospects of Asparaginase. In: Mathé, G. (eds) Advances in the Treatment of Acute (Blastic) Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 30 . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35334-9_5
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