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Active Immunotherapy in the Treatment of Leukemia and Other Malignant Diseases in Animals and Man

  • G. Hamilton Fairley
  • D. Crowther
  • J. G. Guyer
  • R. M. Hardisty
  • H. E. M. Kay
  • P. J. Knapton
  • T. J. McElwain
  • I. B. Parr
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 30)

Abstract

It has been known for many years that various agents including oleic acid, BCG, and zymosan, which are capable of causing hyperplasia of the reticulo-endothelial system, also have the effect of retarding the growth of some tumours as well as accelerating homograft rejection (Murphy, 1924; Old et al., 1961; Weiss et al., 1961). Subsequently Halpern et al. (1963) and Smith and Woodruff (1968) showed a similar effect with Corynebacterium parvum.

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References

  1. Halpern, B. N., Prevot, A. R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y., Decreusefond, C.: Stimulation de l’activité phagocytaire du système réticulo-endothélial provoquée par Corynébacterium parvum. J. Reticulo-endothelial Soc. 1, 77 (1963).Google Scholar
  2. Hamilton Fairley, G.: Immunity to malignant disease in man. Brit. med. J. 2, 467 (1969).CrossRefGoogle Scholar
  3. Mathé, G., Amiel, J. L., Schwarzenberg, L., Schneider, M., Cattan, A., Schlumberger, J. R., Hayat, M., de Vassal, F.: Démonstration de l’efficacité de l’immunothérapie active dans la leucémie aiguë lymphoblastique humaine. Rev. franç. Étud. clin. biol. 13, 454 (1968).PubMedGoogle Scholar
  4. Murphy, J. B.: The lymphocyte in resistance to tissue grafting, malignant disease and tuberculosis infection. An experimental study. Monogr. Rockefeller Inst. med. Res. 21 (1926).Google Scholar
  5. Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., Stockert, E.: The role of the reticulo-endothelial system in the host reaction to neoplasia. Cancer Res. 21, 1281 (1961).PubMedGoogle Scholar
  6. Smith, L. H., Woodruff, M. F. A.: Comparative effect of two strains of C. parvum on phagocytic activity and tumour growth. Nature (Lond.). 219, 197 (1968).CrossRefGoogle Scholar
  7. Weiss, D. W., Bonhag, R. S., DeOrme, K. B.: Protective activity of fractions of tubercle bacilli against isologous tumours in mice. Nature (Lond.). 190, 889 (1961).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1970

Authors and Affiliations

  • G. Hamilton Fairley
    • 1
  • D. Crowther
    • 1
  • J. G. Guyer
    • 1
  • R. M. Hardisty
    • 1
  • H. E. M. Kay
    • 1
  • P. J. Knapton
    • 1
  • T. J. McElwain
    • 1
  • I. B. Parr
    • 1
  1. 1.Institute of Cancer ResearchRoyal Marsden Hospital, and Hospital for Sick ChildrenBelmont, SuttonEngland

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