Active Immunotherapy in the Treatment of Leukemia and Other Malignant Diseases in Animals and Man
It has been known for many years that various agents including oleic acid, BCG, and zymosan, which are capable of causing hyperplasia of the reticulo-endothelial system, also have the effect of retarding the growth of some tumours as well as accelerating homograft rejection (Murphy, 1924; Old et al., 1961; Weiss et al., 1961). Subsequently Halpern et al. (1963) and Smith and Woodruff (1968) showed a similar effect with Corynebacterium parvum.
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