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Antimalarial Drugs I pp 265–280Cite as

Malaria Models in Simian Hosts

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68))

Abstract

Recognition by Moore and Lanier (1961) and Young and Moore (1961) of Plasmodium falciparum strains resistant to chloroquine, coupled with the disease among United States service personnel caused by such resistant strains, required the finding of a small, readily obtainable animal susceptible to human plasmodia for the evaluation of candidate antimalarial drugs. At Gorgas Memorial Laboratory Young et al. (1966) demonstrated that the Panamanian Aotus trivirgatus (owl monkey) would support development of Plasmodium vivax obtained from a human patient. A year later, Geiman and Meagher (1967) reported the successful adaptation of an East African strain of P. falciparum in A. trivirgatus of Colombian origin. The Colombian A. trivirgatus model, infected with strains of P. falciparum of diverse susceptibilities and/or resistance to chloroquine, pyrimethamine, and quinine, afforded the basis for intensive investigations. Schmidt (1969) recognised the value of the owl monkey model for evaluating new antimalarials.

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Authors
  1. R. N. Rossan
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Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Scientific Advisory Services, Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts, HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph.D. (Manager) (Manager)

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© 1984 Springer-Verlag Berlin Heidelberg

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Rossan, R.N. (1984). Malaria Models in Simian Hosts. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drugs I. Handbook of Experimental Pharmacology, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35326-4_9

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  • DOI: https://doi.org/10.1007/978-3-662-35326-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-34991-5

  • Online ISBN: 978-3-662-35326-4

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