Malaria Models in Simian Hosts
Recognition by Moore and Lanier (1961) and Young and Moore (1961) of Plasmodium falciparum strains resistant to chloroquine, coupled with the disease among United States service personnel caused by such resistant strains, required the finding of a small, readily obtainable animal susceptible to human plasmodia for the evaluation of candidate antimalarial drugs. At Gorgas Memorial Laboratory Young et al. (1966) demonstrated that the Panamanian Aotus trivirgatus (owl monkey) would support development of Plasmodium vivax obtained from a human patient. A year later, Geiman and Meagher (1967) reported the successful adaptation of an East African strain of P. falciparum in A. trivirgatus of Colombian origin. The Colombian A. trivirgatus model, infected with strains of P. falciparum of diverse susceptibilities and/or resistance to chloroquine, pyrimethamine, and quinine, afforded the basis for intensive investigations. Schmidt (1969) recognised the value of the owl monkey model for evaluating new antimalarials.
KeywordsQuinoline Phenanthrene Trop Clindamycin Trimethoprim
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