Skip to main content
SpringerLink
Log in
Book cover

Antimalarial Drugs I pp 461–473Cite as

Experimental Production of Drug Resistance

  • Chapter

  • 170 Accesses

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68))

Abstract

A decade ago I made the following statement: “reviewing the literature now with the wisdom bestowed by hindsight one is impressed by the relative ease with which resistance can be induced to almost any antimalarial drug. The method employed may facilitate the process but is, in most cases, not over-important” (Peters 1970). This statement is still valid. A number of additional techniques for the experimental production of drug resistance have since been published and these are incorporated in Table 1.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Beale GH, Carter R, Walliker D (1978) Genetics. In: Killick-Kendrick R, Peters W (eds) Rodent malaria. Acadomic, London

    Google Scholar 

  • Bishop A (1958) An analysis of the development of resistance to metachloridine in clones of Plasmodium gallinaceum. Parasitology 48:210–234

    Article  PubMed  CAS  Google Scholar 

  • Bishop A, McConnachie FW (1950) Cross resistance between sulphanilamide and Paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide. Parasitology 40:175–178

    Article  PubMed  CAS  Google Scholar 

  • Brockleman CR, Monkolkeha S, Tanariya P (1981) Decrease in susceptibility of Plasmodium falciparum to melloquine in continuous culture. Bull WHO 59:249–252

    Google Scholar 

  • Bryson V, Szybalski W (1955) Microbial drug resistance. Adv Genet 7:1–46

    Article  PubMed  CAS  Google Scholar 

  • Burgess RW, Young MD (1959) The development of pyrimethamine resistance by Plasmodium falciparum. Bull WHO 20:37–46

    PubMed  CAS  Google Scholar 

  • Cook MK (1958) The development of a pyrimethamine-resistant line of Toxoplasma under in vitro conditions. Am J Trop Med Hyg 7:400–402

    PubMed  CAS  Google Scholar 

  • Diggens SM, Gutteridge WE, Trigg PI (1970) Altered dihydrofolate reductase associated with a pyrimethamine-resistant Plasmodium berghei produced in a single step. Nature 228:579–580

    Article  PubMed  CAS  Google Scholar 

  • Greenberg J (1956) Mixed lethal strains of Plasmodium gallinaceum: drug-sensitive, transferable (SP) × drug-resistant, non-transferable (BI). Exp Parasitol 5:359–370

    Article  PubMed  CAS  Google Scholar 

  • Greenberg J, Trembley HL (1954) The apparent transfer of pyrimethamine resistance from the BI strain of Plasmodium gallinaceum to the M strain. J Parasitol 40:667–672

    Article  PubMed  CAS  Google Scholar 

  • Haynes JD, Diggs CL, Hines CL, Desjardins RE (1976) Culture of human malaria parasites, Plasmodium falciparum. Nature 263:767–769

    Article  PubMed  CAS  Google Scholar 

  • Hollingdale MR, Leef JL, McCullough M, Beaudoin RL (1981) In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei from sporozoites. Science 213:1021–1022

    Article  PubMed  CAS  Google Scholar 

  • Merkli B, Peters W (1976) A comparison of two different methods for the selection of primaquine resistance in Plasmodium berghei berghei. Ann Trop Med Parasitol 70:473–474

    PubMed  CAS  Google Scholar 

  • Nguyen-Dinh P, Trager W (1978) Chloroquine resistance produced in vitro in an African strain of human malaria. Science 200:1397–1398

    Article  PubMed  CAS  Google Scholar 

  • Peters W (1965) Morphological and physiological variations in chloroquine-resistant Plasmodium berghei, Vincke and Lips, 1948. Ann Soc Belg Med Trop 45:365–378

    CAS  Google Scholar 

  • Peters W (1968) The chemotherapy of rodent malaria, V: dynamics of drug resistance, Part I: methods for studying the acquisition and loss of resistance to chloroquine by Plasmodium berghei. Ann Trop Med Parasitol 62:277–287

    PubMed  CAS  Google Scholar 

  • Peters W (1970) Chemotherapy and drug resistance in malaria. Academic, London

    Google Scholar 

  • Peters W (1980) Chemotherapy of malaria. In: Kreier JP (ed) Malaria, vol 1. Academic, New York, pp 145–283

    Google Scholar 

  • Peters W, Porter M (1976) The chemotherapy of rodent malaria, XXVI: the potential value of WR 122455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites. Ann Trop Med Parasitol 70:271–281

    PubMed  CAS  Google Scholar 

  • Peters W, Portus JH, Robinson BL (1975) The chemotherapy of rodent malaria, XXII: the value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity. Ann Trop Med Parasitol 69:155–171

    PubMed  CAS  Google Scholar 

  • Peters W, Bafort J, Ramkaran AE, Portus JH, Robinson BL (1970) The chemotherapy of rodent malaria, XI: cyclically transmitted, chloroquine-resistant variants of the Keyberg 173 strain of Plasmodium berghei. Ann Trop Med Parasitol 64:41–51

    PubMed  CAS  Google Scholar 

  • Peters W, Chance ML, Lissner R, Momen M, Warhurst DC (1978) The chemotherapy of rodent malaria, XXX: the enigmas of the “NS line” of P. berghei. Ann Trop Med Parasitol 72:23–36

    PubMed  CAS  Google Scholar 

  • Powers KG, Jacobs RL, Good WC, Koontz LC (1969) Plasmodium vinckei: production of chloroquine-resistant strain. Exp Parasitol 26:193–202

    Article  PubMed  CAS  Google Scholar 

  • Ramakrishnan SP, Satya P, Sen Gupta GP (1956) Studies on Plasmodium berghei, Vincke and Lips, 1948, XXIII: isolation of and observations on a “milk-resistant” strain. Indian J Malariol 10:175–182

    PubMed  Google Scholar 

  • Rollo IM (1968) The mode of action of antimalarials. In: Da Silva JR, Ferreira MJ (eds) Proceedings of the 3 rd international pharmacological meeting, São Paulo, 1966. Pergamon, Oxford, pp 45–50

    Google Scholar 

  • Rosario VE (1976) Genetics of chloroquine resistance in malaria parasites. Nature 261:585–586

    Article  PubMed  CAS  Google Scholar 

  • Sinden RE, Smith J (1980) Culture of the liver stages (exoerythrocytic schizonts) of rodent malaria parasites from sporozoites in vitro. Trans R Soc Trop Med Hyg 74:134–136

    Article  PubMed  CAS  Google Scholar 

  • Strome CPA, De Santis PL, Beaudoin RL (1979) The cultivation of the exoerythrocytic stages of Plasmodium berghei from sporozoites. In Vitro 15:531–536

    Article  PubMed  CAS  Google Scholar 

  • Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193:673–675

    Article  PubMed  CAS  Google Scholar 

  • Trager W, Robert-Gero M, Lederer E (1978) Antimalarial activity of S-isobutyl adenosine against Plasmodium falciparum in culture. FEBS Lett 85:264–266

    Article  PubMed  CAS  Google Scholar 

  • Walliker D, Sanderson A, Yoeli M, Hargreaves BJ (1976) A genetic investigation of virulence in a rodent malaria parasite. Parasitology 72:183–194

    Article  PubMed  CAS  Google Scholar 

  • Warhurst DC, Folwell RO (1968) Measurement of the growth rate of the erythrocytic stages of Plasmodium berghei and comparison of the potency of inocula after various treatments. Ann Trop Med Parasitol 62:349–360

    PubMed  CAS  Google Scholar 

  • Yoeli M, Upmanis RS, Most H (1969) Drug resistance transfer among rodent plasmodia, I: acquisition of resistance to pyrimethamine by a drug-sensitive strain of P. berghei in the course of its concomitant development with a pyrimethamine-resistant P. vinckei strain. Parasitology 59:429–447

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. Peters
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Scientific Advisory Services, Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts, HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph.D. (Manager) (Manager)

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Peters, W. (1984). Experimental Production of Drug Resistance. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drugs I. Handbook of Experimental Pharmacology, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35326-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-35326-4_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-34991-5

  • Online ISBN: 978-3-662-35326-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation