Evaluation of Drug Resistance in Man
Drug resistance in malaria can be defined as the “ability of a parasite strain to survive and/or multiply despite the administration and absorption of a drug given in doses equal to or higher than those usually recommended but within the limits of tolerance of the subject” (WHO 1967). Although this definition could logically be applied to include all plasmodial stages, it has generally been restricted to describe the drug susceptibility of asexual blood forms, presumably because this stage in the life cycle of the parasite produces the acute clinical symptoms observed during the course of a malaria infection. Resistance of asexual blood forms to drugs has been reported in all species of human plasmodia. However, because of the appearance of chloroquine-resistant infections of falciparum malaria about 2 decades ago, attention has been focused on developing procedures for assessing the response of Plasmodium falciparum to chloroquine and other antimalarial drugs.
KeywordsAntimalarial Drug Falciparum Malaria Drug Susceptibility Asexual Parasite Chloroquine Resistance
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- Lopez Antuñano FJ, Wernsdorfer WH (1980) In vitro response of chloroquine-resistant Plasmodium falciparum to mefloquine. Bull WHO 57:663–665Google Scholar
- Rieckmann KH (1972) In vitro assessment of the sensitivity of Plasmodium falciparum to chloroquine at Kisumu, Kenya and Lagos, Nigeria. WHO/MAL 72:792 (Cyclostyled report) WHO, GenevaGoogle Scholar
- Rieckmann KH (1980) Susceptibility of cultured parasites of Plasmodium falciparum to antimalarial drugs. In: Rowe DS, Hirumi H (eds) The in vitro cultivation of the pathogens of tropical diseases. Tropical diseases research series, No. 3. Schwabe, Basel, pp 35-50Google Scholar
- Rieckmann KH, Willerson WD Jr, Carson PE, Frischer H (1972) Effects of tetracycline against drug-resistant falciparum malaria. Proc Helminthol Soc Wash 39:339–347Google Scholar
- Valera CV, Shute GT (1975) Preliminary studies on the response of Plasmodium falciparum to chloroquine in the Philippines using the in vitro technique. WHO/MAL 75:852 (Cyclostyled report) WHO, GenevaGoogle Scholar
- WHO (1967) Chemotherapy of malaria. Report of a WHO scientific group. WHO Tech Rep Ser 375:42Google Scholar
- WHO (1973) Chemotherapy of malaria and resistance to antimalarials. Report of a WHO scientific working group. WHO Tech Rep Ser 529:30Google Scholar
- WHO (1979) Instructions for use of the WHO test kit for assessment of the response of Plasmodium falciparum to chloroquine. WHO/MAP 79:1 (Cyclostyled report) WHO GenevaGoogle Scholar