Evaluation of Drug Resistance in Man

  • K. H. Rieckmann
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 68)


Drug resistance in malaria can be defined as the “ability of a parasite strain to survive and/or multiply despite the administration and absorption of a drug given in doses equal to or higher than those usually recommended but within the limits of tolerance of the subject” (WHO 1967). Although this definition could logically be applied to include all plasmodial stages, it has generally been restricted to describe the drug susceptibility of asexual blood forms, presumably because this stage in the life cycle of the parasite produces the acute clinical symptoms observed during the course of a malaria infection. Resistance of asexual blood forms to drugs has been reported in all species of human plasmodia. However, because of the appearance of chloroquine-resistant infections of falciparum malaria about 2 decades ago, attention has been focused on developing procedures for assessing the response of Plasmodium falciparum to chloroquine and other antimalarial drugs.


Antimalarial Drug Falciparum Malaria Drug Susceptibility Asexual Parasite Chloroquine Resistance 
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© Springer-Verlag Berlin Heidelberg 1984

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  • K. H. Rieckmann

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