Nephrology pp 990-995 | Cite as

In Situ Immune Complex Nephritis

  • Arnold Vogt


Until the beginning of the nineteen eighties it was generally believed that glomerulonephritis was a “soluble complex disease” [1–3], the exception being that induced by anti-GBM antibody. Glomerular injury was considered to be the result of antigen-antibody deposits, with inflammation-inducing properties, which had previously been formed within the circulation [4]. This way of looking at things—for a long time it almost had the status of a dogma—was eventually challenged by Couser and Salant [5], who pointed at observations in passive Heymann nephritis, where the disease is not the result of circulating immune complexes but arises from combinations of the anti FxlA antibody with particular surface structures of the glomerular epithelial cells [6,7]. The main target molecule has been identified as a glycoprotein of 330 kD, known as gp 330 [8].


Immune Complex Lupus Nephritis Glomerular Basement Membrane Yersinia Enterocolitica Glomerular Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cameron JS (1983) The pathogenesis of glomerulonephritis. In: Bertani T, Remuzzi G (eds) Glomerular injury. 300 years after Morgagni. Wichtig Edition, Milan, pp 11–30Google Scholar
  2. 2.
    Dixon FJ (1968) The pathogenesis of glomerulonephritis. Am J Med 44: 493–498PubMedCrossRefGoogle Scholar
  3. 3.
    Wilson CB, Dixon FJ (1981) The renal response to immunological injury. In: Brenner BM, Rector FC (eds) The kidney. WB Saunders, Philadelphia, p 1237Google Scholar
  4. 4.
    Cochrane CG, Koffler D (1973) Immune complex disease in experimental animals and in man. Adv Immunol 16: 185–264PubMedCrossRefGoogle Scholar
  5. 5.
    Couser WG, Salant DJ (1980) In situ immune complex formation and glomerular injury (editorial review). Kidney Int 17: 1–13PubMedCrossRefGoogle Scholar
  6. 6.
    Van Damme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. IV. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 38: 502–510Google Scholar
  7. 7.
    Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62: 1275–1287PubMedCrossRefGoogle Scholar
  8. 8.
    Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (GP 330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157: 667–685PubMedCrossRefGoogle Scholar
  9. 9.
    Izui S, Schur PH, Kunkel HG (1967) Immunologic studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126: 607–623CrossRefGoogle Scholar
  10. 10.
    Stoeckl F, Schmiedeke T, Sugisaki Y, Mertz A, Batsford S, Vogt A (1990) DNA has no affinity for the GBM in vivo: binding is mediated by histone (abstract). Kidney Int 37: 434Google Scholar
  11. 11.
    Golbus SM, Wilson CB (1979) Experimental glomerulonephritis induced by in situ formation of immune complexes in the glomerular capillary wall. Kidney Int 16: 148–157PubMedCrossRefGoogle Scholar
  12. 12.
    Holthofer H (1983) Lectin binding sites in kidney: A comparative study of 14 animal species. J Histochem Cytochem 31: 431–537CrossRefGoogle Scholar
  13. 13.
    Ward HJ, Cohen AH, Border WA (1984) In situ formation of subepithelial immune complexes in the rabbit glomerulus: requirement of a cationic antigen. Nephron 36: 257–264PubMedCrossRefGoogle Scholar
  14. 14.
    Border WA, Ward HJ, Kamil ES, Cohen AH (1982) Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen: Demonstration of a pathogenic role for electrical charge. J Clin Invest 69: 451–461Google Scholar
  15. 15.
    Gallo GR, Caulin-Glaser T, Lamm ME (1981) Charge of circulating immune complexes as a factor in glomerular basement membrane localization in mice. J Clin Invest 67: 13051313Google Scholar
  16. 16.
    Caulin-Glaser T, Gallo GR, Lamm EM (1983) Nondissociating cationic immune complexes can deposit in glomerular basement membrane. J Exp Med 158: 1561–1572PubMedCrossRefGoogle Scholar
  17. 17.
    Gallo GR, Caulin-Glaser T, Emancipator SN, Lamm ME (1983) Nephritogenicity and differential distribution of glomerular immune complexes related to immunogen charge. Lab Invest 48: 353–362PubMedGoogle Scholar
  18. 18.
    Batsford SR, Takamiya H, Vogt A (1980) A model of in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen. Clin Nephrol 14: 211–216PubMedGoogle Scholar
  19. 19.
    Batsford SR, Oite T, Takamiya H, Vogt A (1980) Anionic binding sites in the glomerular basement membrane: possible role in the pathogenesis of immune complex glomerulo-nephritis. Renal Physiol 3: 336–340PubMedGoogle Scholar
  20. 20.
    Oite T, Batsford SR, Mihatsch MJ, Takamiya H, Vogt A (1982) Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen. J Exp Med 155: 460–474PubMedCrossRefGoogle Scholar
  21. 21.
    Vogt A, Rohrbach R, Shimizu F, Takamiya H, Batsford S (1982) Interaction of cationized antigen with rat glomerular basement membrane: In situ immune complex formation. Kidney Int 22: 27–35Google Scholar
  22. 22.
    Oite T, Shimizu F, Suzuki Y, Vogt A (1985) Ultramicroscopic localization of cationized antigen in the glomerular basement membrane in the course of active, in situ complex glomerulonephritis. Virchows Arch [Cell Pathol] 48: 107–118CrossRefGoogle Scholar
  23. 23.
    Koyama A, Niwa Y, Shigematsu H, Taniguchi M, Tada T (1978) Studies on passive serum sickness. II. Factors determining the localization of antigen-antibody complexes in murine renal glomerulus. Lab Invest 38: 253–262Google Scholar
  24. 24.
    Germuth FG Jr, Rodriguez E (1973) Immunopathology of the renal glomerulus. Immune complex deposit and anti-basement membrane disease. Little, Brown, BostonGoogle Scholar
  25. 25.
    Germuth FG Jr, Rodriguez E, Lorelle CA, Trump ER, Milano LL, Wise 0 (1979) Passive immune complex glomerulonephritis in mice: Models for various lesions found in human disease: II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. Lab Invest 41. 366–371Google Scholar
  26. 26.
    Koyama A, Inage H, Kobayashi M, Ohta Y, Narita M, Tojo S, Cameron JS (1986) Role of antigenic charge and antibody avidity on the glomerular immune complex localization in serum sickness of mice. Clin Exp Immunol 64: 606–614PubMedGoogle Scholar
  27. 27.
    Barnes JL, Radnik RA, Gilchrist EP, Venkatachalam MA (1984) Size and charge selective permeability defects induced in glomerular basement membrane by a polycation. Kidney Int 25: 11–19PubMedCrossRefGoogle Scholar
  28. 28.
    Barnes JL, Ventakachalam MA (1984) Enhancement of glomerular immune complex deposition by a circulating polycation. J Exp Med 160: 286–293PubMedCrossRefGoogle Scholar
  29. 29.
    Schmiedeke TMJ, Stöckl FW, Weber R, Sugisaki Y, Batsford S, Vogt A (1989) Histones have high affinity for the glomerular basement membrane: relevance for immune complex formation in Lupus nephritis. J Exp Med 169: 1879–1894PubMedCrossRefGoogle Scholar
  30. 30.
    Schmiedeke T, Stoeckl F, Muller S, Mertz A, Vogt A (1990) Detection of histone H3 and H2A in glomerular deposits of Lupus mice (abstract). Kidney Int 37: 430Google Scholar
  31. 31.
    Gioud M, Ait Kaci M, Montier JC (1982) Histone antibodies in systemic Lupus erythematosus. Arthritis Rheum 25: 407–413PubMedCrossRefGoogle Scholar
  32. 32.
    Vogt A, Batsford S, Rodriguez-Iturbe B, Garcia R (1983) Cationic antigens in poststreptococcal glomerulonephritis. Clin Nephrol 20: 271–279PubMedGoogle Scholar
  33. 33.
    Liu TY, Elliot SD (1971) Streptococcal proteinase. In: Buyer (ed) The enzymes, vol 3, 3rd edn. Academic, pp 609–647Google Scholar
  34. 34.
    Johnston KH, Zabriskie JB (1986) Purification and partial characterization of the nephritis strain-associated protein from streptococcus pyogenes, group A. J Exp Med 163: 697–712PubMedCrossRefGoogle Scholar
  35. 35.
    Lange K, Seligson G, Cronin W (1983) Evidence for the in situ origin of poststreptococcal glomerulonephritis: glomerular localization of endostreptosin and the clinical significance of the subsequent antibody response. Clin Nephrol 19: 3–16PubMedGoogle Scholar
  36. 36.
    Mertz A, Batsford S, Stoeckl F, Vogt A (1990) Yersinia enterocolitica induced acute GN: Possible role of nucleic acid-binding proteins in immune complex formation (abstract). Kidney Int 37: 423Google Scholar
  37. 37.
    Yousif Y, Mertz A, Batsford S, Vogt A (to be published) Cationic staphylococcal antigens have affinity for renal basement membrane: possible pathogenetic role in glomerulonephritis. Proceedings of the VIth international symposium on staphylococci and staphylococcal infections, September 4–8 1989 Warsaw, Poland. Jeljaszewicz J (ed) Gustav Fischer, StuttgartGoogle Scholar

Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Arnold Vogt
    • 1
  1. 1.Institute of Medical MicrobiologyFreiburgFederal Republic of Germany

Personalised recommendations