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Nephrology pp 908-914 | Cite as

The Renal Biology of Endothelins

  • Barry M. Brenner
  • Andrew J. King

Summary

Endothelin (ET) is distinguished from other endogenous vasoactive peptides by its biphasic pressure response and its sustained duration of action. There is marked regional variability in the sensitivity to either the vasodilatory or the vasoconstrictor effects of ET. The renal vascular bed is exquisitely sensitive and may be an important target organ for ET. The extent to which ET functions as an auto-crine, paracrine, or circulating mediator is as yet unclear. Evidence suggests that ET may play a role as a mediator of chronic volume and blood pressure regulation and contribute to sustained renal ischemia in pathophysiological states. Eventual development of effective blockers of ET action will aid in understanding the in vivo effects of ET.

Keywords

Atrial Natriuretic Peptide Mesangial Cell Renal Plasma Flow Inositol Trisphosphate Renal Vasoconstriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Barry M. Brenner
    • 1
    • 2
  • Andrew J. King
    • 1
    • 2
  1. 1.Renal Division and Department of MedicineBrigham and Women’s HospitalBostonUSA
  2. 2.The Harvard Center for the Study of Kidney DiseasesHarvard Medical SchoolBostonUSA

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