Nephrology pp 348-355 | Cite as

Macula Densa Control of Renin Secretion and Proximal Tubular Pressure

  • Paul P. Leyssac


Early studies suggested that the proximal tubular pressure was regulated by a negative feedback mechanism operating via the juxtaglomerular (JG) apparatus, involving changes in renin secretion. Subsequent and recent studies have confirmed this hypothesis. The tubuloglomerular feedback (TGF) response oscillates with a frequency of about 30 mHz, and is sensitive to changes in late proximal flow of less than 3 nl.min−1. It is specifically abolished by loop diuretics. Micropuncture studies have shown that single nephron renin release is increased when Henle loop flow is decreased and conversely, that single nephron renin release is decreased when Henle loop flow is increased. Studies on isolated JG-apparatuses have shown that this is due to the flow-dependent changes in luminal sodium chloride concentration at the level of the macula densa (M.D.). Thus, both the TGF-mediated afferent vasoconstriction and the M.D.-mediated renin secretion share the same luminal signal. The intracellular (i.c.) signal is probably also the same, since an increase in i.c. calcium causes vasoconstriction and inhibition of renin release from the JG cells. Both responses may therefore be considered as part of the TGF-mechanism.


Loop Diuretic Renin Release Renin Secretion Oncotic Pressure Efferent Arteriole 
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  1. 1.
    Leyssac PP, Holstein-Rathlou N-H (1988) Dynamics of TGF mediated regulation of proximal tubular pressure. Role of the renin system. In: Persson AEG, Boberg U (eds) The juxtaglomerular apparatus, Fernström Foundation Series vol 11. Elsevier Scientific, Amsterdam, pp 237–247Google Scholar
  2. 2.
    Leyssac PP (1969) New aspects of the mechanisms of renal sodium excretion. Proc R Soc Med 62: 1111–1116PubMedGoogle Scholar
  3. 3.
    Leyssac PP, Baumbach L (1983) An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney. Acta Physiol Scand 117: 415–419PubMedCrossRefGoogle Scholar
  4. 4.
    Leyssac PP (1986) Further studies on oscillating tubulo-glomerular feedback responses in the rat kidney. Acta Physiol Scand 126: 271–277PubMedCrossRefGoogle Scholar
  5. 5.
    Holstein-Rathlou N-H (1987) Synchronization of proximal intratubular pressure oscillations: evidence for interaction between nephrons. Pflugers Arch 408: 438–443PubMedCrossRefGoogle Scholar
  6. 6.
    Leyssac PP, Holstein-Rathlou N-H (1986) Effects of various transport inhibitors on oscillating TGF pressure responses in the rat. Pflugers Arch 407: 285–291PubMedCrossRefGoogle Scholar
  7. 7.
    Holstein-Rathlou N-H, Leyssac PP (1987) Oscillations in the proximal intratubular pressure: a mathematical model. Am J Physiol 252: F560 - F572PubMedGoogle Scholar
  8. 8.
    Leyssac PP (1964) The effect of partial clamping of the renal artery on pressures in the proximal and distal tubules and peritubular capillaries of the rat kidney. Acta Physiol Scand 62: 449–456PubMedCrossRefGoogle Scholar
  9. 9.
    Leyssac PP (1986) Changes in single nephron renin release are mediated by tubular fluid flow rate. Kidney Int 30: 332–339PubMedCrossRefGoogle Scholar
  10. 10.
    Skutt O, Briggs JP (1987) Direct demonstration of macula densa-mediated renin secretion. Science 237: 1618–1620CrossRefGoogle Scholar
  11. 11.
    Baumbach L, Leyssac PP (1977) Studies on the mechanism of renin release from isolated superfused rat glomeruli: effects of calcium, calcium ionophore and lanthanum. J Physiol 273: 745–764PubMedGoogle Scholar
  12. 12.
    Kurtz A, Penner R (1989) Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells. Proc Natl Acad Sci USA 86: 3423–3427PubMedCrossRefGoogle Scholar
  13. 13.
    SkOtt O (1986) Episodic release of renin from single isolated superfused rat afferent arterioles. Pflügers Arch 407: 41–45PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Paul P. Leyssac
    • 1
  1. 1.Institute of Experimental MedicineUniversity of CopenhagenCopenhagenDenmark

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