Nephrology pp 1113-1121 | Cite as

Application of the Amiloride Series in the Study of Ion Transport

  • Thomas R. Kleyman


Amiloride and amiloride analogs have been extensively used as inhibitors of Na+-selective transport proteins. The interaction of amiloride analogs with the epithelial Na+ channel, Na+/H+ exchanger, and Na+/Ca2+ exchanger is summarized. The potential use of amiloride analogs as biochemical probes for amiloride-sensitive transport proteins, and as immunologic tools for development of antibodies directed against these proteins is discussed, as are some of the limitations and problems encountered using amiloride analogs as “specific” inhibitors of defined transport proteins.


Hydrophobic Group Apical Plasma Membrane Frog Skin Epithelial Sodium Channel Toad Urinary Bladder 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Thomas R. Kleyman
    • 1
  1. 1.Renal and Electrolyte Section-700 CRBUniversity of PennsylvaniaPhiladelphiaUSA

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