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Lipids and the Pathogenesis of Kidney Disease

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Book cover Nephrology

Summary

The nephrotic syndrome presents clinically with a pattern of proteinuria, edema, albuminuria, hypoalbuminemia, and hyperlipidemia. Despite, or perhaps because of, familiarity with the syndrome, its possible implications for the progression of renal disease have been neglected. However, a large amount of information has been accumulated from animal models in the last decade, which, in aggregate, strongly suggests an important role for abnormalities of lipid metabolism in progressive renal disease. This review considers the metabolic background against which some of the pathological changes in animal models of nephrotic syndrome take place. Analogies between glomerular disease and atherosclerosis are discussed in the context of cellular pathology, the cardiovascular complications of nephrosis, and the relative protection of females from atherosclerosis. The role of lipid lowering drugs is discussed in relation to disease prevention in animal models. Reference is made to the role of excess eicosanoid synthesis in glomerular disease. Lack of information on the value or otherwise of long term lipid lowering therapy in patients with proteinuria, hyperlipidemia, and progressive renal disease emphasizes the need for long term studies of lipid lowering therapy in these patients.

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Authors and Affiliations

  1. Department of Nephrology, The Royal Free Hospital, Hampstead, London, NW3 2QG, UK

    John F. Moorhead

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  1. John F. Moorhead
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Editors and Affiliations

  1. Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

    Michinobu Hatano M.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1991 Springer Japan

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Moorhead, J.F. (1991). Lipids and the Pathogenesis of Kidney Disease. In: Hatano, M. (eds) Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35158-1_11

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  • DOI: https://doi.org/10.1007/978-3-662-35158-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-70074-6

  • Online ISBN: 978-3-662-35158-1

  • eBook Packages: Springer Book Archive

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