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Clonal Aspects of Muscle Development and the Stability of the Differentiated State

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The Stability of the Differentiated State

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 1))

Abstract

The stability of the differentiated state has the kind of catchy sonority which leaves the impression that some natural law is being stated; when, in fact, the phrase more truthfully refers to a broad, ill-defined, and unresolved set of questions with different connotations for different investigators. The various connotations are, in turn, intimately linked to numerous and diverse experimental systems, which can be considered under several broad operational categories: (1) the ability of differentiated cells to retain their specialized characteristics when cultured in vitro ; (2) the ability of relatively undifferentiated cells to retain their capacity for differentiation after an extended proliferative or resting phase (as is the case for hemopoeitic stem cells); (3) the ability of cells to leave the differentiated state, undergo a proliferative phase, and then return to a differentiated state (as in the case of liver and amphibian limb regeneration) ; (4) the ability of nuclei from differentiated cells to function in foreign cytoplasmic environments.

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Authors and Affiliations

  1. Department of Biochemistry, University of Washington, Seattle, Washington, 98102, USA

    Stephen D. Hauschka

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  1. Stephen D. Hauschka
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Editors and Affiliations

  1. Baltimore, USA

    H. Ursprung

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© 1968 Springer-Verlag Berlin Heidelberg

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Hauschka, S.D. (1968). Clonal Aspects of Muscle Development and the Stability of the Differentiated State. In: Ursprung, H. (eds) The Stability of the Differentiated State. Results and Problems in Cell Differentiation, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35089-8_4

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  • DOI: https://doi.org/10.1007/978-3-662-35089-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-34768-3

  • Online ISBN: 978-3-662-35089-8

  • eBook Packages: Springer Book Archive

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