Relation Between Various Types of Curves Expressing Response of Cells to Drugs

  • A. J. Clark
Part of the Handbuch der Experimentellen Pharmakologie book series (HDBEP)

Abstract

Gaddum (1937)1 has suggested that since skew variation is a natural characteristic of living tissues, therefore the shape of all the curves expressing pharmacological responses can be interpreted as expressions of variation. In support of this hypothesis it can be pointed out that growth must tend to produce skew variation in any population as regards many of its characteristics.

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References

  1. 1.
    Gaddum, J. H.: Proc. roy. Soc. B. 121, 598 (1937).Google Scholar
  2. 1.
    Stanley, W. M.: Science (N. Y.) 81, 644 (1935).CrossRefGoogle Scholar
  3. 2.
    Samuel, G., and J. G. Bald: Ann. appl. Biol. 20, 70 (1933).CrossRefGoogle Scholar
  4. 3.
    Holmes, F. O.: Bot. Gaz. 87, 39 (1929).CrossRefGoogle Scholar
  5. 1.
    Holmes, F. O.: Bot. Gaz. 87, 39 (1929).CrossRefGoogle Scholar
  6. 2.
    Caldwell, J.: Proc. roy. Soc. B. 119, 493 (1936).CrossRefGoogle Scholar
  7. 3.
    Samuel, G., and J. G. Bald: Ann. appl. Biol. 20, 70 (1933).CrossRefGoogle Scholar
  8. 1.
    Hill, A. V.: J. of Physiol. 39, 361 (1909).Google Scholar
  9. 2.
    Clark, A. J.: The Mode of Action of Drugs on Cells. London: Arnold and Co. 1933.Google Scholar
  10. 3.
    Laubender, W., and H. Kolb: Arch. f. exper. Path. 182, 401 (1936).CrossRefGoogle Scholar
  11. 1.
    Fühner, H.: Heffters Handb. exper. Pharmakol. 1, 640 (1923).Google Scholar
  12. 2.
    Beznak, A. B. L.: J. of Physiol. 82, 129 (1934).Google Scholar
  13. 3.
    Clark, A. J.: J. of Physiol. 64, 123 (1927).Google Scholar
  14. 4.
    White, A. C., and E. Stedman: J. Pharmacol. Baltimore 41, 259 (1931).Google Scholar
  15. 5.
    Langecker, H.: Arch. f. exper. Path. 118, 49 (1926).CrossRefGoogle Scholar
  16. 1.
    Gaddum, J. H.: J. of Physiol. 61, 141 (1926).Google Scholar
  17. 2.
    Wilkie, D.: J. Pharmacol. Baltimore 34, 1 (1928).Google Scholar
  18. 3.
    Hunt, Reid: Amer. J. of Physiol. 5, 7 (1901).Google Scholar
  19. 5.
    Weizsäcker, V.: Pflügers Arch. 147, 135 (1912).CrossRefGoogle Scholar
  20. 6.
    Pickford, L. M.: J. of Physiol. 63, 19 (1927).Google Scholar
  21. 7.
    Strand, A. L.: Industr. Engineer., Chem. Analyt. Sect. 2, 4 (1930).CrossRefGoogle Scholar
  22. 8.
    Trevan, J. W.: J. of Path. 32, 127 (1929).CrossRefGoogle Scholar
  23. 9.
    Hartley, P., H. J. Parish, G. E. Petrie and W. Smith: Lancet 1933 II, 91CrossRefGoogle Scholar
  24. 1.
    Arrhenius, S.: Quantitative Laws in Biological Chemistry. London: Bell and Sons 1915Google Scholar
  25. 2.
    Hartley, P., H. J. Parish, G. E. Petrie and W. Smith: Lancet 1933 II, 91.CrossRefGoogle Scholar
  26. 3.
    Marrian, G. P., and A. S. Parkes: J. of Physiol. 67, 389 (1929).Google Scholar
  27. 4.
    Coward, K. H., and J. H. Burn: J. of Physiol. 63, 270 (1927)Google Scholar
  28. 5.
    Hill, R. T., A. S. Parkes and W. E. White: J. of Physiol. 81, 335 (1934).Google Scholar
  29. 6.
    Gallagher T. F, and F. C. Koch: J. Pharmacol. Baltimore 55, 97 (1935).Google Scholar
  30. 7.
    Clark, A.J.: The Mode of Action of Drugs on Cells. London: Arnold and Co. 1933Google Scholar
  31. 8.
    Sherif, M. A. F.: J. pharmacol. Baltimore 56, 1 (1936).Google Scholar
  32. 1.
    Sherif, M. A. F.: J. pharmacol. Baltimore 56, 1 (1936).Google Scholar
  33. 1.
    Knoefel, P. K., and F. C. Murrell: J. Pharmacol. Baltimore 55, 235 (1935).Google Scholar
  34. 2.
    Clark, A. J.: The Mode of Action of Drugs on Cells. London: Arnold and Co. 1933.Google Scholar
  35. 3.
    Takahashi, Y.: Okayama-Igakkai-Zasshi No. 429, 1020 (1925).Google Scholar
  36. 4.
    Tattersfield, F., C. T. Gimingham and H. M. Morris: Ann. appl. Biol. 12, 218 (1925).CrossRefGoogle Scholar
  37. 1.
    McCallan, S. E. A., and F. Wilcoxon: Contrib. Boyce Thompson Instit. 3, 13, 31 (1931).Google Scholar
  38. 1.
    Tattersfield, F., C. T. Gimingham, and J.M. Morris: Ann. appl. Biol. 12, 218 (1925).CrossRefGoogle Scholar
  39. 2.
    Tattersfield, F., and C. T. Gimingham: Ann. appl. Biol. 14, 217 (1927).CrossRefGoogle Scholar
  40. 1.
    Trivelli, A. P. H., and P. R. Loveland: J. Franklin Instit. 209, 639 (1930).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1937

Authors and Affiliations

  • A. J. Clark
    • 1
  1. 1.EdinburghUK

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