Phenomenon of the adaptive stabilization of sarcoplasmic and nuclear structures in myocardium

  • I. Yu. Malyshev
  • A. B. Shneider
  • F. Z. Meerson


In adaptation of rats to repeated stress exposure, a mechanism gradually forms at the level of heart to provide a considerable increase in the organ resistance to reperfusion paradox and toxic concentrations of catecholamines and Ca2 +. Sarcoplasmic reticulum and mitochondria isolated from the hearts of adapted animals are highly resistant to autolysis, and nuclei to the damaging action of one-chain DNA. These changes are named phenomenon of the adaptive stabilization of structures (PhASS). An important role of myocardial heat shock protein (HSP) accumulation in the mechanism of PhASS is shown. The development of PhASS is accompanied by an increased resistance of myocardium to ischemic necrosis.

Key words

Adaptation stress autolysis DNA stress-limiting systems 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Aschenbrenner V, Druyan R, Albin R, Rabinovitz M (1970) Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver. Biochem J 119: 157–168PubMedGoogle Scholar
  2. 2.
    Currie RW, White FP (1981) Trauma-induced protein in rat tissues: a physiological role for a “heat shock protein”? Science 214: 72–73PubMedCrossRefGoogle Scholar
  3. 3.
    Hammond DL, Lai JK, Markert CL (1982) Diverse forms of stress lead to a new pattern of gene expression through a common and essential metabolic pathway. Proc Natl Acad Sci USA 79: 3485PubMedCrossRefGoogle Scholar
  4. 4.
    Hearse DJ, Humphrey SM, Chain EB (1973) Abrupt reoxygenation of the anoxic potassium arrested perfused rat heart. J Mol Cell Cardiol 5: 395–401PubMedCrossRefGoogle Scholar
  5. 5.
    Malyshev IYu (1989) Adaptation of the organism to stress exposure increases the heart resistance to adrenotoxic damage (in Russian). Bull Exper Biol Med 4: 411–413Google Scholar
  6. 6.
    Meerson FZ (1988) The role of lipid peroxidation in the myocardium in stress and the antioxidant protection of the heart. In: Singal PK (ed) Oxygen radicals in the pathophysiology of heart disease. Kluwer Academic Publishers, Boston, pp 285–301CrossRefGoogle Scholar
  7. 7.
    Meerson FZ (1991) Adaptive protection of the heart: protecting against stress and ischemic damage. CRC Press, Boca RatonGoogle Scholar
  8. 8.
    Meerson FZ (1990) Phenomenon of the adaptive stabilization of structures and protection of the heart (in Russian). Kardiologiya 3: 6–12Google Scholar
  9. 9.
    Meerson FZ, Malyshev IYu, Sazontova TG (1990) Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca’ on the heart by increased activity of sarcoplasmic reticulum. Basic Res Cardiol 85: 96–103PubMedCrossRefGoogle Scholar
  10. 10.
    Meerson FZ, Pshennikova MG, Belkina LM, Abdikaliev NA, Malyshev IYu (1989) Prevention of ischemic arrhythmias by activation of stress-limiting systems of the organism. CV World Report 2: 205–212Google Scholar
  11. 11.
    Meerson FZ, Sazontova TG, Arkhipenko YuV (1990) Increased resistance of cardiac sarcoplasmic reticulum Cat + pump to autolysis after adaptation of rats to stress. Biomed Sci 1: 373–378PubMedGoogle Scholar
  12. 12.
    Schwartz K, Boheler KR, Chassagne C, Bastie D, Mercadier JJ (1990) The mechanogenic transduction of the hypertrophied mammalian myocardium. J Mol Cell Cardiol 22 (Suppl II): 8Google Scholar
  13. 13.
    Watson JV, Nakeff A, Chambers SH, Smith PS (1985) Flow cytometric fluorescence emission spectrum analysis of Hoechst 33343 strained DNA in chicken thymocytes. Cytometry 6: 310–315PubMedCrossRefGoogle Scholar
  14. 14.
    Zak R, Aschenbrenner V, Rabinowitz M (1971) Synthesis and degradation of myosin in cardiac hypertrophy. J Clin Invest 50: 1020Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • I. Yu. Malyshev
    • 1
  • A. B. Shneider
    • 1
  • F. Z. Meerson
    • 1
    • 2
  1. 1.Institute of General Pathology and Pathological Physiology of the USSR AMSMoscowUSSR
  2. 2.USSR Academy of Medical SciencesInstitute of General Pathology and Pathological PhysiologyMoscow-315USSR

Personalised recommendations