Phenomenon of the adaptive stabilization of sarcoplasmic and nuclear structures in myocardium
In adaptation of rats to repeated stress exposure, a mechanism gradually forms at the level of heart to provide a considerable increase in the organ resistance to reperfusion paradox and toxic concentrations of catecholamines and Ca2 +. Sarcoplasmic reticulum and mitochondria isolated from the hearts of adapted animals are highly resistant to autolysis, and nuclei to the damaging action of one-chain DNA. These changes are named phenomenon of the adaptive stabilization of structures (PhASS). An important role of myocardial heat shock protein (HSP) accumulation in the mechanism of PhASS is shown. The development of PhASS is accompanied by an increased resistance of myocardium to ischemic necrosis.
Key wordsAdaptation stress autolysis DNA stress-limiting systems
Unable to display preview. Download preview PDF.
- 5.Malyshev IYu (1989) Adaptation of the organism to stress exposure increases the heart resistance to adrenotoxic damage (in Russian). Bull Exper Biol Med 4: 411–413Google Scholar
- 7.Meerson FZ (1991) Adaptive protection of the heart: protecting against stress and ischemic damage. CRC Press, Boca RatonGoogle Scholar
- 8.Meerson FZ (1990) Phenomenon of the adaptive stabilization of structures and protection of the heart (in Russian). Kardiologiya 3: 6–12Google Scholar
- 10.Meerson FZ, Pshennikova MG, Belkina LM, Abdikaliev NA, Malyshev IYu (1989) Prevention of ischemic arrhythmias by activation of stress-limiting systems of the organism. CV World Report 2: 205–212Google Scholar
- 12.Schwartz K, Boheler KR, Chassagne C, Bastie D, Mercadier JJ (1990) The mechanogenic transduction of the hypertrophied mammalian myocardium. J Mol Cell Cardiol 22 (Suppl II): 8Google Scholar
- 14.Zak R, Aschenbrenner V, Rabinowitz M (1971) Synthesis and degradation of myosin in cardiac hypertrophy. J Clin Invest 50: 1020Google Scholar