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Chemiluminescence as a marker of myocardial ischemia

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Current Topics in Heart Failure

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Summary

Dog experiments were performed using the measurement of tissue chemiluminescence to clarify the peculiar role of reactive oxygen species in ischemic heart damage. Following left thoracotomy and pericardiotomy, the left anterior descending coronary artery (LAD) was ligated for 2 h and 24 h. Epicardial and endocardial muscle specimens were excised, homogenized, and centrifuged to detect chemiluminescent difference in the supernatants after t-butyl hydroperoxide induction at each time interval. Characteristic alterations were found between the infarcted region, border zone, and intact area. The induced photoemission differs in an altered kinetic as well as in intensity values. It is assumed that interrelations exist between the observed light burst and the actual scavenger state. Antioxidant application advantageously modifies the chemiluminescence effect, especially at the border zone. Induced chemiluminescence is a good method to characterize ischemically altered myocardial cellular metabolism.

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Author information

Authors and Affiliations

  1. Institute of Experimental Surgery, University School of Medicine Pécs, Hungary

    Prof. Dr. B. Török

  2. Dept. of Experimental Surgery, University of Medicine Pécs, Kodály Zoltan u. 20, H-7643, Pécs, Hungary

    Prof. Dr. B. Török

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  1. Prof. Dr. B. Török
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Editors and Affiliations

  1. Physiologisches Institut II, Universität Tübingen, Gmelinstraße 5, 7400, Tübingen, Germany

    Rainer W. Gülch  & Gerolf Kissling  & 

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© 1991 Springer-Verlag Berlin Heidelberg

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Török, B. (1991). Chemiluminescence as a marker of myocardial ischemia. In: Gülch, R.W., Kissling, G. (eds) Current Topics in Heart Failure. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-30769-4_11

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  • DOI: https://doi.org/10.1007/978-3-662-30769-4_11

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-0894-1

  • Online ISBN: 978-3-662-30769-4

  • eBook Packages: Springer Book Archive

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