Abstract
Infections are the major cause of morbidity and mortality in adults with acute myelogenous leukemia (AML) [1, 2]. The risk of fatal infection during remission induction therapy approaches 50%. Infection and the threat of infection frequently compromises the administration of chemotherapy. Thus, any program which would substantially diminish the risk of infection should allow for more effective and prolonged administration of chemotherapeutic agents.
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References
Hersh, E. M., Bodey, G. P., Nies, B. A., Freireich, E. J.: Causes of death in acute leukemia. J. Amer. med. Ass. 193, 105–109 (1965).
Bodey, G. P.: Infectious complications of acute leukemia. Med. Times 94, 1076–1085 (1966).
White, L. P., Claffin, E. J.: Nitrogen mustard — Diminution of toxicity in axenic mice. Science 140, 1400–1401 (1963).
Wilson, B. R.: Survival studies of whole-body x-irradiated gum-free (axenic) mice. Radiat. Res. 20, 477–483 (1963).
Griswold, D. P., Laster, W. R., Jr., Snow, M. Y., Schabel, F. M., Jr., Skipper, H. E.: Experimental evaluation of potential anticancer agents. XII. Quantitative drug response of the SA 180, CA 755 and leukemia L 1210 systems to a “standard list” of “active” and “inactive” agents. Cancer Res. 23(4) Part 2, 271–519 (1963).
Skipper, H. E., Schabel, F. M., Jr., Wilcox, W. S.: Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with “curability” of experimental leukemia. Cancer Chemother. Rep. 35, 1–111 (1964).
Bodey, G. P., Loftis, J., Bowen, E.: Protected environment for cancer patients. Effects of an oral antibiotic regimen on the microbial flora of patients undergoing chemotherapy. Arch. intern. Med. 122, 23–30 (1968).
— Kim, Z., Bowen, E.: A semiquantitative total body skin culture technique for patients in a protected environment. Amer. J. Med. Sci. 257, 100–115 (1969).
— Hart, J., Freireich, E. J., Frei, E., III.: Studies of a patient isolator unit and prophylactic antibiotics in cancer chemotherapy. Cancer 22, 1018–1026 (1968).
— Laminar air flow unit for patients undergoing cancer chemotherapy. Germ-free Biology. Plenum Press 1969.
— Gewertz, B.: Microbiological studies of a laminar air flow unit for patients. Arch. Environmental Health 19, 798–805 (1969).
— Freireich, E. J., Frei, E., III.: Studies of patients in a laminar air flow unit. Cancer 24, 972–980 (1969).
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Bodey, G.P., Rodriguez, V., Freireich, E.J., Frei, E. (1970). Protected Environment, Prophylactic Antibiotics and Cancer Chemotherapy. In: Mathé, G. (eds) Aseptic Environments and Cancer Treatment. Recent Results in Cancer Research, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-30758-8_4
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DOI: https://doi.org/10.1007/978-3-662-30758-8_4
Publisher Name: Springer, Berlin, Heidelberg
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