Abstract
Intensive chemotherapy and radiotherapy in current use in the treatment of malignant disease have given some outstanding results (Mathé et al., 1968) but they can cause, virtually inevitably, periods of profound hypo- or aplasia of the haemopoietic and lymphopoietic systems, whose main complication is infection. Infection has become one of the principal problems in the practice of modern cancer therapy, being particularly formidable in malignant disease of the haemopoietic system, especially in leukaemic, where bone marrow insufficiency is often present before giving any treatment. In a recent study of acute leukaemia, treated with intensive chemotherapy, Frei and his colleagues (1965) reported 60 per cent incidents of bacterial infection with 40 per cent of septicaemia, and 64 per cent incidents of fungal infections with 34 per cent of septicaemia. Autopsy examination has confirmed that infection is the commonest direct cause of death in these cases.
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Mathé, G. et al. (1970). Five Years Experience of the Clinical Use of a Pathogen-Free Isolation Unit. In: Mathé, G. (eds) Aseptic Environments and Cancer Treatment. Recent Results in Cancer Research, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-30758-8_2
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DOI: https://doi.org/10.1007/978-3-662-30758-8_2
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