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Vergleichende Untersuchungen über den Stoffwechsel der verschiedenen Arten und Varianten der Gattung Mycobacterium

(Möglichkeiten einer Stoffwechselsystematik der Tuberkelbakterien)
  • Rudolf Bönicke
Part of the Tuberkulose-Forschungsinstitut Borstel book series (TBC BORSTEL, volume 1956/57)

Zusammenfassung

Die durch die gegenwärtig vorwiegend chemotherapeutische Behandlung der Tuberkulose bedingte Ausweitung und Intensivierung der bakteriologischen Arbeit hat zur Entdeckung neuer, bisher nicht bekannter Formen, Varianten und Arten des Mycobacteriums geführt, die, obwohl größtenteils nicht pathogen für das Meerschweinchen in ihrer Morphologie und ihrem kulturellen Verhalten den echten Tuberkelbakterien in vielen Fällen so ähnlich sind, daß eine Differenzierung von diesen erhebliche Schwierigkeiten bereitet. Die Drogenresistenz, vor allem die mit der Isoniazidresistenz gekoppelte Virulenzschwächung der Tuberkelbakterien hat zu einer weiteren Erschwerung der differential-diagnostischen Arbeit geführt. Es ist mit den heute bekannten und allgemein verwendeten Verfahren zur Differenzierung der einzelnen Arten und Varianten der Gattung Mycobacterium nicht mehr möglich, bestimmte apathogene oder auch pathogene, „saprophytäre“ Mycobakterien mit Sicherheit von isoniazidresistenten, virulenzgeschwächten Tuberkelbakterienstämmen oder gar von isoniazidresistenten BCG-Stämmen bzw. von avirulenten humanen Stämmen des Ra-Typs zu unterscheiden.

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© Springer-Verlag Berlin Heidelberg 1957

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  • Rudolf Bönicke

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