Stoffwechsel pp 115-124 | Cite as

Die Aufnahme von 15N im Muskeleiweiß von einem Patienten in katabolem Zustand

  • P. Fürst
  • B. Josephson
  • E. Vinnars
Part of the Anaesthesiology and Resuscitation / Anaesthesiologie und Wiederbelebung / Anesthésiologie et Réanimation book series (A+I, volume 58)

Zusammenfassung

Kürzlich haben wir von Untersuchungen berichtet, bei denen wir den Stickstoffumsatz bei gesunden Versuchspersonen [6], bei Patienten in posttraumatisch-katabolem Zustand [20] und bei urämischen Patienten [4] mit Hilfe von schwerem Stickstoff studierten. Diese Arbeiten beinhalten Bestimmungen der Einlagerung von 15N in Muskelprotein und in „proteinfreies Filtrat“ der Intrazellulärflüssigkeit von Muskulatur. Die Muskelanalysen waren dadurch möglich, daß wir mit Hilfe von Nadelbiopsie [1] wiederholte Proben von Muskelgewebe desselben Individuums unter verschiedenen metabolischen Versuchsbedingungen entnommen haben. Soweit wir wissen, sind Studien über die Umsetzung von Muskelprotein beim Menschen mit Hilfe der 15N-Einlagerung im Muskelprotein in vivo noch nicht veröffentlicht worden. Diese Technik haben wir nun bei einem Patienten in schwerem posttraumatischen Katabolismus angewendet, wobei wir auch die Möglichkeit hatten, die 15N-Einlagerung in aktivem und in inaktiviertem Muskelgewebe festzustellen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1972

Authors and Affiliations

  • P. Fürst
    • 1
  • B. Josephson
    • 1
  • E. Vinnars
    • 1
  1. 1.Klinisch-chemisches Laboratorium und die Abteilung für AnaesthesiologieStockholmSchweden

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