Abstract
Tripterygium species (family Celastraceae) are distributed in the temperate zone of East Asia, from the east coast of China to Korea, Taiwan, and to the west coast of Japan; four to five species, including T. wilfordii and T. hypoglaucum, have been recorded (Willis 1973). Most are deciduous, vine-like liana woody shrubs, 2 to 4 m in height, growing in the sunny hilly regions, and covering the vegetation. Tripterygium species are important as a Chinese herbal remedy, and are also used as ornamentals, especially in flower arrangements.
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References
Buckanin RS, Chen SJ, Frieze DM, Sher FT, Berchtold GA (1980) Total synthesis of triptolide and triptonide. J Am Chem Soc 102(3): 1200–1201
Cheng CY (1981) Chinese Celastraceae. Its taxonomy and antineoplastic aspects. Planta Med 39(3): 257–258
Chen K, Shi Q, Fujioka T, Zhang DC, Hu CQ, Jin JQ, Kilkuskie RE, Lee KH (1992a) Anti-aids agents, 4. Tripterifordin a novel anti-HIV principle from Tripterygium wilfordii isolation and structural elucidation. J Nat Prod 55(1): 88–92
Chen K, Shi Q, Kashiwada Y, Zhang DC, Hu CQ, Jin JQ, Nozaki H, Kilkuskie RE, Tramontano E (1992b) Anti-aids agents. 6. Salaspermic acid an anti-HIV principle from Tripterygium wilfordii and the structure-activity correlation with its related compounds. J Nat Prod 55(3): 340–346
Chiu SF, Huang BQ, Hu MY (1989) Synergistic effect of toosendanin in admixture with Bacillus thuringiensis and other insecticides against the cabbage worm Pieris papae L. Acta Entomol Sin 32(2): 158–165
Dujack LW, Chen PK (1980) Antineoplastic diterpenes in Tripterygium wilfordii tissue culture. The effects of precursors on diterpene production. In Vitro 16:216
Feuell AJ (1965) Insecticides. Verlag J Cramer, Weinheim, p 43
Gu WZ, Bradnwein SR, Banerjee S (1992) Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook F. J Rheumatol 19(5): 682–68
Hori H, Pang GM, Harimaya K, Iitaka Y, Inayama S (1987) Isolation and structure of regelin and regelinol. New antitumor ursene-type triptepenoids from Tripterygium wilfordii. Chem Pharm Bull 35(5): 2125–2128
Kupachan SM, Schubert RM (1974) Selective alkylation a biomimetic reaction of the anti leukemic triptolides. Science 185:791–793
Kupchan SM, Court WA, Dailey RG, Gilmore CJ, Bryan RF (1972) Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc 94:7194–7195
Kutney JP, Beale MH, Salisbury PJ, Sindelar RD, Stuart KL, Worth BR, Townsley PM, Chalmers WT, Donnelly DJ, Nilsson K, Jacoli GG (1980) Tripdiolide from tissue culture of Tripterygium wilfordii. Heterocycles 14:1465–1467
Kutney JP, Hewitt GM, Kurihara T, Salisbury PJ, Sindelar RD, Stuart KL, Townsley PM, Chalmers WT, Jacoli GG (1981) Cytotoxic diterpenes triptolide, tripdiolide and cytotoxic triterpenes form tissue cultures of Tripterygium wilfordii. Can J Chem 59:2677–2683
Kutney JP, Choi LSL, Duffin R, Hewitt G, Kawamura N, Kurihara T, Salisbury P, Sindelar R, Stuart KL (1983) Cultivation of Tripterygium wilfordii tissue cultures for the production of the cytotoxic diterpene tripdiolide. Planta Med 48(3): 158–163
Kutney JP, Hewitt GM, Lee G, Piotrowska K, Roberts M, Rettig SJ (1992) Studies with tissue cultures of the Chinese herbal plant Tripterygium wilfordii. Isolation of metabolites of interest in rheumatoid arthritis immunosuppression and male contraceptive activity. Can J Chem 70(5): 1455–1480
Kutney JP, Samija MD, Hewitt GM, Bugante EC, Gu H (1993) Antiinflammatory oleanane triterpenes from Tripterygium wilfordii cell suspension cultures by fungal elicitation. Plant Cell Rep 12:356–359
Lai CK, Buckanin RS, Chen SJ, Zimmerman DF, Sher FT, Berchtold GA (1982) Total synthesis of racemic triptolide and racemic triptonide. J Org Chem 47:2364–2369
Lan ZJ, Gu ZP, Lu RF, Zhuang LZ (1992) Effects of multiglycosides of Tripterygium wilfordii GTW on rat fertility and Leydig and Sertoli cells. Contraception 45(3): 249–261
Li XW, Weir MR (1990) Radix Tripterygium wilfordii, a Chinese herbal medicine with potent immunosuppressive properties. Transplantation 50(1): 82–86
Li XY (1991) Immunomodulating Chinese herbal medicines. Mem Inst Oswaldo Cruz Rio J 86(Suppl 2): 159–164
Ma PC, Lu XY, Yang JJ, Zheng QT (1991) 16-Hydroxytriptolide a new active diterpene isolated from Tripterygium wilfordii. Acta Pharm Sin 26(10): 459–763
Misawa M, Hayashi M, Takayama S (1983) Production of antineoplastic agents by plant tissue cultures. 1. Induction of callus tissues and detection of the agents in cultured cells. Planta Med 49:115–119
Misawa M, Hayashi M, Takayama S (1985) Accumulation of antineoplastic agents by plant tissue cultures. In: Neumann KH, Barz W, Reinhard E (eds) Primary and secondary metabolism of plant cell cultures. Springer Berlin Heidelberg, New York, pp 235–246
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol plant 15:473–497
Pepin MF, Chavarie C, Archambault J (1991) Growth and immobilization of Tripterygium wilfordii cultured cells. Biotechnol Bioeng 38:1285–1291
Perdue RE (1976) Antitumor agents from higher plants. Some practical and economic considerations. Lloydia 39(6): 469
Shin FC (1989) Studies on plants as a source of insect growth regulators for crop protection. J Appl Entomol 107(2): 185–192
Takayama S (1991) Antitumor agents from woody plants. In: Komamine A (ed) Plant cell culture in Japan. CMC, Tokyo, pp 19–26
Takayama S, Misawa M, Hayashi M (1983) Production of anti-cancer agents by tissue culture of Tripterygium wilfordii. Selection of tripdiolide and triptolide high yielding cell strain. Proc 1983 Meet Japanese Soc Plant Physiol, 279 pp
Tian J, She Z, Zhou X, Gu H, Zhang D, Jin J (1992) The effect of Tripterygium wilfordii on spermatogenic cells and LDH-C4 activity in male rats. Acta Acad Med Shanghai 19(1): 37–40
Van Tamelen EE, Demers JP, Taylor EG, Koller K (1980) Total synthesis of l-triptonide and l-triptolide. J Am Chem Soc 102:5424–5425
Wei YS, Adachi I (1991) Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. Acta Pharmacol Sin 12(5): 406–410
Willis JC (1973) A dictionary of flowering plants and ferns, 8th edn. Revised by Airy Shaw HK. University Press, Cambridge
Xiao X, Endo T, Watanabe K, Kumano K, Koshiba K (1992) Immunosuppressive activity of multiglycosides of Tripterygium wilfordii GTW on skin allografts in rats. Nephrol Dial Transplant 7(7):787
Zhang TM, Chen ZY, Lin C (1981) Antineoplastic action of triptolide and its effect on the immunologic functions in mice. Acta Pharmacol Sin 2(2): 128–131
Zheng YL, Xu Y, Lin JF (1989) Immunosuppressive effects of wilfortrine and euonine. Acta Pharm Sin 24(8): 568–572
Zhou BN (1991) Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz Rio J 86(Suppl 2): 219–226
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© 1994 Springer-Verlag Berlin Heidelberg
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Takayama, S. (1994). Tripterygium wilfordii: In Vitro Culture and the Production of the Anticancer Compounds Tripdiolide and Triptolide. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants VII. Biotechnology in Agriculture and Forestry, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-30369-6_28
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DOI: https://doi.org/10.1007/978-3-662-30369-6_28
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