Advertisement

Pathogenesis and therapy of shock due to infection: experimental and clinical studies

  • W. W. Spink

Abstract

The problem of shock due to infection received only random interest by investigators prior to World War II. This is in contrast to the more intensive studies carried out on shock caused by hemorrhage, trauma and burns. Research on shock and infection should be expanded for at least two reasons. First, although the advances in surgical techniques and the availability of blood and blood substitutes have contributed to a better treatment of shock, simultaneously the factor of infection has been brought into sharper focus. Second, while the management of infections has been greatly benefited by the introduction of the sulfonamides and antibiotics, these drugs in turn have led to additional problems in this field. The widespread use of chemotherapeutic agents has resulted in the emergence of antibiotic-resistant strains of staphylococci, often complicating the treatment of patients with shock. In addition, antibiotic-susceptible invasive bacteria have frequently been eliminated from the tissues, leaving the less virulent and resistant species, such as the gram-negative coliform bacilli, to multiply and to cause serious disease. The increasing importance of sepsis due to these gram-negative organisms became apparent during World War II (1, 2, 3, 4, 5, 6, 7). This report is largely concerned with sepsis and shock due to gram-negative coliform bacteria.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Batterell, E. H., and D. Magner: Lancet (G.B.) 1945/I, 112.Google Scholar
  2. 2.
    Floret, M. E., R. W. N. L. Ross, and E. C. Turton: Lancet (G.B.) 1947/I, 855.Google Scholar
  3. 3.
    Waisbren, B. A.: Arch. Int. Med. (U.S.A.) 88, 467 (1951).CrossRefGoogle Scholar
  4. 4.
    Yow, E. M.: J. Amer. Med. Ass. 149, 1184 (1952).CrossRefGoogle Scholar
  5. 5.
    Weil, M. H., and W. W. Spink: Arch. Int. Med. (U.S.A.) 101, 184 (1958).CrossRefGoogle Scholar
  6. 6.
    Forkner, C. E. Jr., E. Frei Iii, J. H. Edgcomb, and J. P. UTz: Amer. J. Med. 25, 877 (1958).CrossRefPubMedGoogle Scholar
  7. 7.
    Finland, M., W. F. Jones, and M. W. Barnes: J. Amer. Med. Ass. 170, 2188 (1959).CrossRefGoogle Scholar
  8. 8.
    Aub, J. C., P. C. Zamecnik, and I. T. Nathason: J. Clin. Invest. (U.S.A.) 26, 394 (1947).CrossRefGoogle Scholar
  9. 9.
    Berg, M., S. A. Levinson, and K. J. Wang: Arch. Path. (U.S.A.) 51, 137 (1951).Google Scholar
  10. 10.
    Bradford, W. Z. Jr., and C. Bachman: Amer. J. Med. Sc. 237, 785 (1959).CrossRefGoogle Scholar
  11. 11.
    Adams, R. H., and J. A. Pritchard: J. Obstetr. Gynaec. (Ind.) 16, 387 (1960).Google Scholar
  12. 12.
    Deane, R. M., and K. P. Russell: Amer. J. Obstetr. Gynec. 79, 528 (1961).Google Scholar
  13. 13.
    Colebrook, L.: A New Approach to the Treatment of Burns and Scalds, Fine Tech. Pub., London 1950.Google Scholar
  14. 14.
    Liedberg, N. C. F., E. Reiss, and C. P. Artz: Surg. Gyn. Obstetr. (U.S.A.) 99, 151 (1954).Google Scholar
  15. 15.
    Lowbury, E. J. L., D. J. Crockett, and D. M. Jackson: Lancet (G.B.) 1954/II, 1151.Google Scholar
  16. 16.
    TumBuscH, W. T., E. H. Vogel Jr., J. V. Butkiewicz, C. D. Graber, D. L. Larson, and E. T. Mitchell’ Septicemia in Burn Injury, U. S. Army Surgical Research Unit, Brooke Army Medical Center, Fort Sam Houston, Texas, Medew-RS-6–60, October 1960.Google Scholar
  17. 17.
    Rosenthal, S. M.: In: The Biochemical Response to Injury, p. 397. Ed. by H. B. Stoner, Oxford; Blackwell Scientific Publications 1960.Google Scholar
  18. 18.
    Editorial: Toxaemia of Burns. Lancet (G.B.) 1960/I, 153.Google Scholar
  19. 19.
    Spink, W. W.: Arch. Int. Med. (U.S.A.) 106, 433 (1960).CrossRefGoogle Scholar
  20. 20.
    Spink, W. W.: Ann. Int. Med. (U.S.A.) 53, 1 (1960).Google Scholar
  21. 21.
    Bennett, I. L. Jr., and L. E. Cluff: Pharmacol. Rev. (U.S.A.) 40, 245 (1960).Google Scholar
  22. 22.
    Gilbert, R. B.: Physiol. Rev. (U.S.A.) 40, 245 (1960).Google Scholar
  23. 23.
    Halberg, F., and W. W. Spink: Laborat. Invest. (U.S.A.) 5, 283 (1956).Google Scholar
  24. 24.
    Weil, M. H., L. D. Maclean, M. B. Visscher, and W. W. Spink: J. Clin. Invest. (U.S.A.) 35, 1191 (1956).CrossRefGoogle Scholar
  25. 25.
    Hinshaw, L., W. W. Spink, J. A. Vick, B. Mallet, and J. Finstad: Amer. J. Physiol. (in press).Google Scholar
  26. 26.
    Delauney, A., P. Bouquet, J. Lebrum, Y. Lehoult, and M. Delauney: J. physiol. (Fr.) 40, 89 (1948).Google Scholar
  27. 27.
    Haddy, F. J.: Amer J Physiol. 198, 161 (1960).PubMedGoogle Scholar
  28. 28.
    Spink, W. W., and M. J. Landeryou: J. Clin. Invest. (U.S.A.) 39, 302 (1960).CrossRefGoogle Scholar
  29. 29.
    Thal, A. P., and W. Egner: J. Exper. Med. (U.S.A.) 113, 67 (1961).CrossRefGoogle Scholar
  30. 30.
    Vick, J.: J. Laborat. Clin. Med. (U.S.A.) 56, 953 (1960).Google Scholar
  31. 31.
    Heiffer, M. H., R. L. Mundy, and B. Mehlman: Amer. J. Physiol. 198, 1307 (1960).PubMedGoogle Scholar
  32. 32.
    Penner, A., and S. H. Klein: J Exper. Med. (U.S.A.) 96, 59 (1952).CrossRefGoogle Scholar
  33. 33.
    Penner, A., and A. I. Berheim: J. Exper. Med. (U.S.A.) 111, 145 (1960).CrossRefGoogle Scholar
  34. 34.
    Weil, M. H., L. D. Maclean, W. W. Spink, and M. B. Visscher: J. Laborat. Clin. Med. (U.S.A.) 48, 661 (1956).Google Scholar
  35. 35.
    Weil, M. H., and W. W. Spink: J. Laborat. Clin. Med. (U.S.A.) 50. 501 (1957).Google Scholar
  36. 36.
    Hinshaw, L. B., J. A. Vick, C. H. Carlson, and Y. L. Fan: Proc. Soc. Exper. Biol. Med. (U.S.A.) 104, 379 (1960).CrossRefGoogle Scholar
  37. 37.
    Spink, W. W.: Yale J. Biol. Med. 30, 355 (1958).PubMedGoogle Scholar
  38. 38.
    Spink, W. W.: In: The Biochemical Response to Injury, pp. 361–376. Ed. by H. B. Stoner, Oxford; Blackwell Scientific Publications 1960.Google Scholar
  39. 39.
    Spink, W. W., and J. Vick: Proc. Soc. Exper. Biol. Med. (U.S.A.) 106, 242 (1961).CrossRefGoogle Scholar
  40. 40.
    Spink, W. W., and J. Vick: Circulation Res. (U.S.A.) 9, 184 (1961).CrossRefGoogle Scholar
  41. 41.
    Mcqueen, E. G., and R. B. I. Morrison: Brit. Heart J. 23, 1 (1961).CrossRefPubMedGoogle Scholar
  42. 42.
    Spink, W. W., and D. Anderson: J. Clin. Invest. (U.S.A.) 33, 540 (1954).CrossRefGoogle Scholar
  43. 43.
    Halberg, F., W. W. Spink, and J. J. Bittner: Endocrinology (U.S.A.) 59, 380 (1956).Google Scholar
  44. 44.
    Vick, J., and W. W. Spin%: Proc. Soc. Exper. Biol. Med. (U.S.A.) 106, 280 (1961).CrossRefGoogle Scholar
  45. 45.
    Vick, J. A., L. B. Hinshaw, and W. W. Spink: Ann N. Y. Acad. Sc. 92, 662 (1961).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1962

Authors and Affiliations

  • W. W. Spink

There are no affiliations available

Personalised recommendations