Abstract
Calcium levels in the blood and in cells are maintained within narrow limits in normal animals, although variations occur in dietary constituents and absorption. This blood balance is maintained primarily by using the calcium reserves in skeletal tissues and modulating its loss in the kidney (15). It is thus essential to understand the underlying role of the cells of these tissues in effecting selective ion distribution, as calcium plays a major role in physiologic processes, and maintenance of appropriate distribution and concentration is mandatory (16). All cells regulate and utilize calcium in some activity, and the means employed by different cell types may be used to give clues to the mechanisms involved in regulating calcium ion distribution in mineralized systems. The following examples are selected to illustrate the diverse distribution and mechanisms of regulation that may by employed.
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References
Borie, A.B.: Membrane transfer of calcium. Clin. Orthop. 52, 267 (1967)
Brighton, C.T. and Hunt, R.M.: Mitochondrial calcium and its role in calcification. Clin. Orthop. 100, 406 (1974)
Curry, D.L., Bennett, L.L. and Grodsky, G.M.: Requirements for calcium ion in insulin secretion by the perfused rat pancreas. Amer. J. Physiol. 214, 174 (1968)
Davis, W.L., Matthews, J.L. and Martin, J.H.: An electron microscopic study of myofilaments calcium binding sites in native, EGTA-chelated and calcium reloaded glycerolated mammalian skeletal muscle. Calc. Tiss. Res. 14, 139 (1974)
Davis, W.L., Matthews, J.L., Martin, J.H. and Talmage, R.V.: The Endosteum as a Functional Membrane. In: Calcium-regulating hormones. Talmage, R.V. and Owen, M. (eds.), Excerpta Med. (Amst.), pp. 275, 1975
Dean, P.M. and Matthews, E.K.: Electrical activity in pancreatic islet cells: Effect of Ions. J. Physiol. (Lond.) 210, 265 (1970)
Douglas, W.S.: Stimulus-secretion coupling: The concept and clues from chromaffin and other cells. Brit. J. Pharmacol. 34, 451 (1968)
Ebashi, S. and Endo, M.: Calcium ion and muscle contraction. Progr. Biophys. Moles. Biol. 18, 123 (1968)
Kanno, Y. and Loewenstein, W.R.: Intracellular diffusion. Science 143, 959 (1964)
Lacy, P.E.: Beta cell secretion from the standpoint of a pathologist. Diabetes 19 895 (1970)
Lehninger, A.L., Carafoli, E. and Rossi, C.S.: Energy-linked ion movements in mitochondrial systems. Advanc. Enzymol. 29, 259 (1967)
Martin, J.H. and Matthews, J.L.: Mitochondrial granules in chondrocytes. Calc. Tiss. Res. 3, 184 (1974)
Martin, J.H., Carson, F.L. and Race, G J.: Calcium-containing platelet granules. J. cell. Biol. 60, 775 (1974)
Matthews, J.L., Martin, J.H., Kennedy, J.W. and Collins, E.J.: An ultrastructural study of calcium and phosphate deposition and exchange in tissues. In: Tissue Growth, Repair and Remineralization. Ciba Symposium. Sognnaes, R.F. and Vaughan, J.M. (eds.), Excerpta Med. (Amst.), pp. 187, 1973
Nordin, B.E.C. and Peacock, M.: Role of kidney in regulation of plasma calcium. Lancet (1969) ii, 1280
Rasmussen, H.: Cell communication, calcium ion, and cyclic adenosine mono-phosphate. Science 170, 404 (1970)
Rasmussen, H. and Bordier, P.: The Physiological and Cellular Basis of Metabolic Bone Disease. Williams and Wilkins, 1974
Robison, G.A., Butcher, R. and Sutherland, E.W.: Cyclic AMP, Academic Press, 1971
Romero, P.J. and Whittam, R.: The control by internal calcium of membrane permeability to sodium and potassium. J. Physiol. (Loud.) 214, 481 (1971)
Sampson, H.W., Matthews, J.L., Martin, J.H. and Kunin, A.S.: An electron microscopic localization of calcium in the small intestine of normal, rachitic, and vitamin-D-treated rats. Calc. Tiss. Res. 4, 305 (1970)
Simson, J.A.V. and Spicer, S.S.: Selective subcellular localization of precipitate using modifications of Kominicks pyroantimonate-osmium technique (Abstr.). J. Histochem. Cytochem. 22, 291 (1974)
Talmage, R.V.: Morphological and physiological considerations in a new concept of calcium transport in bone. Amer. J. Anat. 129, 467 (1970)
Talmage, R.V., Matthews, J.L., Davis, W.L., Martin, J.H. and Roycraft, J.H. Jr.: Calcitonin, phosphate and the osteocyte-osteoblast bone cell unit. In: Calcium-regulating hormones. Talmage, R.V. and Owen, M. (eds.), Excerpta Med. (Amst.), pp. 284, 1975
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Davis, W.L., Matthews, J.L., Talmage, R.V., Martin, J.H. (1976). Morphology of Cell Calcium Homeostasis. In: Nielsen, S.P., Hjørting-Hansen, E. (eds) Calcified Tissues 1975. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29272-3_8
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DOI: https://doi.org/10.1007/978-3-662-29272-3_8
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