Abstract
In recent years evidence has been provided that during uremia various active transport processes are impaired (8, 1). Kinetic alterations of the sarcoplasmic reticulum (SR) of rabbit skeletal muscle were observed by Ritz and Matthews (6). In the following, some of the altered kinetic parameters of this well established active transport system will be presented. It will be shown that they are paralleled by alterations of the protein and lipid moiety of the SR membrane. Some of these alterations are also found in non-sarcoplasmic membranes and lipoproteins.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baerg, H.D., Kimberg, D.V. and Gershon, E.: Effect of renal insufficiency on the active transport of calcium by the small intestine. J. Clin. Invest. 49, 1288–1300 (1970)
Hasselbach, W. and Makinose, M.: Die Calciumpumpe der “Erschaffungsgrana” des Muskels und ihre Abhängigkeit von der ATP-Spaltung. Biochem. Z. 333, 518–528 (1961)
Hasselbach, W. and Makinose, M.: Über den Mechanismus des Calciumtransportes durch die Membranen des sarkoplasmatischen Retikulums. Biochem. Z. 339, 94–111 (1963)
Kimelberg, H.K. and Papahadjopoulos, D.: Effects of Phospholipid Acyl Chain Fluidity, Phase Transitions and Cholesterol on (Na+ + K+)-stimulated Adenosine Triphosphatase. J. Biol. Chem. 249, 1071–1080 (1974)
Papahadjopoulos, D., Cowden, M. and Kimelberg, H.: Role of Cholesterol in Membranes: Effects on Phospholipid-Protein Interactions, Membrane Permeability and Enzymatic Activity. Biochem. Biophys. Acta 330, 8–26 (1973)
Ritz, E., Bundschu, H.D. and Hasselbach, W.: Calcium Uptake by Sarcoplasmic Reticulum in Experimental Uremia. IXth Europ. Symp. Calc. Tiss. Baden near Vienna 1972, Czitober, H. and Eschberger, J. ( eds. ), Facta-Publication Vienna, pp. 361–364, 1973
Rottem, S., Cirillo, V.P., De Kruyff, B., Shinitzky, M. and Razin, S.: Cholesterol in Mycoplasma Membranes: Correlation of Enzymic and Transport Activities with Physical State of Lipids in Membranes of Mycoplasma Mycoides Var. Capri Adapted to Grow with Low Cholesterol Concentrations. Biochem. Biophys. Acta 323, 509–519 (1973)
Welt, L.G., Sachs, J.R. and McManus, T.J.: An ion transport defect in erythrocytes from uremic patients. Trans. Amer. Ass. Physic. 77, 169–181 (1969)
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Heimberg, KW., Matthews, C., Ritz, E. (1976). Ca Transport of Sarcoplasmic Reticulum During Experimental Uremia. In: Nielsen, S.P., Hjørting-Hansen, E. (eds) Calcified Tissues 1975. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29272-3_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-29272-3_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-27776-8
Online ISBN: 978-3-662-29272-3
eBook Packages: Springer Book Archive