Duodenal Calcium-binding-protein (CaBP) in the Sodium Deficient Growing Rat

  • M. Thomasset
  • P. Cuisinier-Gleizes
  • H. Mathieu


During the past decade a specific calcium binding protein (CaBP) was detected in the intestinal mucosa of several species (6, 11). The exact role of this protein is not yet clearly defined. There is, however, a high direct correlation between CaBP and the duodenal capacity to transport calcium under definite conditions known to alter calcium absorption.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Birge, S J., Gilbert, H.R. and Avioli, L.V.: Intestinal calcium transport: The role of sodium. Science 176, 168–170 (1972)PubMedCrossRefGoogle Scholar
  2. 2.
    Birge, S.J. and Gilbert, H.R.: Identification of an intestinal sodium and calcium dependent phosphatase stimulated by parathyroid hormone. J. clin. Invest. 54, 710–717 (1974)PubMedCrossRefGoogle Scholar
  3. 3.
    Boyle, I.T., Gray, R.W. and DeLuca, H.F.: Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proc. nat. Acad. Sci. (Wash.) 68, 2131–2134 (1972)CrossRefGoogle Scholar
  4. 4.
    Cuisinier-Gleizes, P. and Mathieu, H.: Effect of low sodium diet on the intestinal absorption of calcium in rats. Rev. franc. Étud. clin. biol. 16, 273–277 (1971)Google Scholar
  5. 5.
    Cuisinier-Gleizes, P., Desbuquois, B. and Mathieu, H.: Mesure de l’absorption intestinale apparente du calcium chez le rat à l’aide de chlorure de chrome radio actif comme marqueur. Rev. franc. Étud. clin. biol. 13, 398–404 (1968)PubMedGoogle Scholar
  6. 6.
    Freund, T. and Bronner, F.: Regulation of intestinal calcium-binding protein by calcium intake in the rat. Amer. J. Physiol. 228, 861–869 (1975)PubMedGoogle Scholar
  7. 7.
    Layne, E.: Spectrophotometric and turbidimetric methods for measuring protein. In: Methods of Enzymology, Colowick, S.P. and Kaplan, N.O. (eds.), Academic Press, New York 3, 447–454 (1957)Google Scholar
  8. 8.
    Martin, D. and DeLuca, H.F.: Influence of sodium on calcium transport by the rat small intestine. Amer. J. Physiol. 216, 1351–1359 (1969)PubMedGoogle Scholar
  9. 9.
    Taylor, A.N. and Wasserman, R.H.: Correlations between the vitamin D-induced calcium binding protein and intestinal absorption of calcium. Fed. Proc. 28, 1834–1838 (1969)PubMedGoogle Scholar
  10. 10.
    Wasserman, R.H., Corradino, R.A. and Taylor, A.N.: Vitamin D-dependent calcium binding protein: Purification and some properties. J. biol. Chem. 243, 3978–3986 (1968)PubMedGoogle Scholar
  11. 11.
    Wasserman, R.H. and Taylor, A.N.: Vitamin D3-induced calcium binding protein in chick intestinal mucosa. Science 152, 791–793 (1966)PubMedCrossRefGoogle Scholar
  12. 12.
    Wasserman, R.H. and Taylor, A.N.: Vitamin D-dependent calcium binding protein: Response to some physiological and nutritional variables. J. biol. Chem. 243, 3987–3993 (1968)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • M. Thomasset
    • 1
  • P. Cuisinier-Gleizes
    • 1
  • H. Mathieu
    • 1
  1. 1.Unite de Recherches sur le Metabolisme Hydro-MineralLe VesinetFrance

Personalised recommendations