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Calcified Tissues 1975 pp 260–266Cite as

Effects of Acute and Chronic PTH Stimulation on Osteoblasts and the Under-lying Bone Matrix

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Abstract

Parathyroid hormone has a profound effect on the synthesis and removal of collagen by the action of bone cells. A peculiar biphasic response of bone collagen synthesis to the administration of PTH can be observed: In acute experiments a decrease of radioproline incorporation into bone collagen is found. After 2–5 days, the rate of collagen synthesis is back to normal and strikingly increased later on.

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References

  1. Boyde, A. & Jones, SJ.: Osteoblasts and bone collagen orientation. Intern. Workshop Calc. Tiss., Gesher Haziv, Israel 1974

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  2. Krempien, B., Geiger, G. & Ritz, E.: Hardness of bone in various ages and diseases. Calc. Tiss. 1972, Proc. 9th Europ. Symp. Calc. Tiss., Czitober, H. and Eschberger, Y. (eds.), Facta Publication, Wien, p 95–99 1973

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  3. Krempien, B., Geiger, G. & Ritz, E.: Structural changes of cortical bone in secondary hyperparathyroidism. Replacement of lamellar bone by woven bone. Virchows Arch. path. Anat. 366, 249 (1975)

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  4. Krempien, B., Geiger, G. & Ritz, E.: Alteration of bone tissue structure in secondary hyperparathyroidism. A scanning electron microschopical study. In: Vitamin D and problems related to uremic bone disease. A.W. Norman et al. (eds.), Gruyter, p 157–165, 1975

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  5. Parsons (see chapter IX, Reeve, J., Tregear, G.W. & Parsons, J.A.).

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Author information

Authors and Affiliations

  1. Department of Pathology and Internal Medicine, University of Heidelberg, Germany

    B. Krempien, G. Geiger & E. Ritz

Authors
  1. B. Krempien
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  2. G. Geiger
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  3. E. Ritz
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Editor information

S. Pors Nielsen E. Hjørting-Hansen

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© 1976 Springer-Verlag Berlin Heidelberg

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Krempien, B., Geiger, G., Ritz, E. (1976). Effects of Acute and Chronic PTH Stimulation on Osteoblasts and the Under-lying Bone Matrix. In: Nielsen, S.P., Hjørting-Hansen, E. (eds) Calcified Tissues 1975. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29272-3_38

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  • DOI: https://doi.org/10.1007/978-3-662-29272-3_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-27776-8

  • Online ISBN: 978-3-662-29272-3

  • eBook Packages: Springer Book Archive

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